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  • Original Paper
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WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type

Abstract

Secreted Frizzled-related protein 1 (SFRP1) encodes a member of a protein family that contains a cysteine-rich domain similar to the WNT-binding site of Frizzled receptors and regulates the WNT pathway. The WNT pathway is frequently altered in human cancers. We have defined the pattern of SFRP1 mRNA expression in the progression of breast cancer. We show that SFRP1 is expressed in the epithelial component of normal breast, in the in situ component of ductal carcinomas and is lost in more than 80% of invasive breast carcinomas except the medullary type. Loss of SFRP1 expression is correlated with the presence of hormonal receptors. Conversely, the maintenance of SFRP1 in carcinomas is correlated with the presence of lymphoplasmocytic stroma. No significant association was observed between SFRP1 status and the level of apoptosis in tumoral cells.

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Acknowledgements

We are indebted to O de Lapeyrière for helpful discussions on the in situ hybridization procedure, and to N Conte for occasional help. This work was supported in part by INSERM and Institut Paoli-Calmettes, and by grants from the Association pour la Recherche sur le Cancer, and Comités des Bouches du Rhône et du Var of the Ligue Nationale contre le Cancer. F Ugolini was a recipient of a fellowship from the Ligue Nationale Contre le Cancer.

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Correspondence to Marie-Josèphe Pébusque.

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Ugolini, F., Charafe-Jauffret, E., Bardou, VJ. et al. WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type. Oncogene 20, 5810–5817 (2001). https://doi.org/10.1038/sj.onc.1204706

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