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Connecting signaling and cell cycle progression in growth factor-stimulated cells

Oncogene volume 19, pages 5558–5567 (2000)Cite this article

Abstract

A widely used model system to investigate cell proliferation is stimulation of serum-arrested cells with growth factors. Recent data suggest that there are two waves of growth factor-dependent signaling events required for a proliferative response. One is an acute burst of signaling, which occurs immediately after growth factor stimulation and lasts for 30–60 min. The other occurs in a different time frame (8–12 h post stimulation), and involves activation of cyclin dependent kinases (Cdks). In addition to a general overview of growth factor-dependent signaling, we present our ‘two wave’ hypothesis for how signaling and cell cycle progression are linked.

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Acknowledgements

We would like to thank Ashley Seifert, Egle Balciunaite, Mark Nickas and Yasushi Ikuno for providing critical input.

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  1. Schepens Eye Research Institute, 20 Staniford Street, Boston, 02114, Massachusetts, MA, USA

    Steven M Jones & Andrius Kazlauskas

  2. Department of Ophthalmology, Harvard Medical School, Boston, 02115, Massachusetts, MA, USA

    Steven M Jones & Andrius Kazlauskas

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Jones, S., Kazlauskas, A. Connecting signaling and cell cycle progression in growth factor-stimulated cells. Oncogene 19, 5558–5567 (2000). https://doi.org/10.1038/sj.onc.1203858

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