Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Report
  • Published:

Human cortactin as putative cancer antigen

Oncogene volume 19, pages 5204–5207 (2000)Cite this article

Abstract

Humoral immune response against overexpressed oncogenic or tumor supressor proteins has been demonstrated for many types of cancer. In this study we report on the detection of the autologous antibody response to putative oncogene, human cortactin using serological analysis of breast carcinoma expression library. Cortactin maps to chromosome 11q13, the region amplified in about 15% of primary breast carcinomas and 30% of head and neck squamous cell carcinomas. Cortactin overexpression due to such amplification might affect adhesive properties of human cancer cells and is associated with poor disease prognosis. Accordingly, we detected overexpression of cortactin transcript in autologous tumor and amplification/overexpression of cortactin in tumors of breast cancer patients serologically positive for this marker. We demonstrate that 15% of breast cancer patients elicit humoral immune response against human cortactin.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  • Bowden ET, Barth M, Thomas D, Glazer RI and Mueller SC. . 1999 Oncogene 18: 4440–4449.

  • Boon T, Cerottini JC, Van den Eynde B, van der Bruggen P and Van Pel A. . 1994 Ann. Rev. Immunol. 12: 337–365.

  • Brass N, Racz A, Bauer C, Heckel D, Sybrecht G and Meese E. . 1999 Blood 93: 2158–2166.

  • Bringuier PP, Tamimi Y, Schuuring E and Schalken J. . 1996 Oncogene 12: 1747–1753.

  • Campbell DH, Sutherland RL and Daly RJ. . 1999 Cancer Res. 59: 5376–5385.

  • D'Arpa P, Machlin PS, Ratrie H III, Rothfield NF, Clevland DW and Earnshaw WC. . 1988 Proc. Natl. Acad. Sci. USA 85: 2543–2547.

  • Disis ML and Cheever MA. . 1996 Curr. Opin. Immun. 8: 637–642.

  • Huang C, Liu J, Haudenschild CC and Zhan X. . 1998 J. Biol. Chem. 273: 25770–25776.

  • Hui R, Ball JR, Macmillan RD, Kenny FS, Prall OW, Campbell DH, Cornish AL, McClelland RA, Daly RJ, Forbes JF, Blamey RW, Musgrove EA, Robertson JF, Nicholson RI and Sutherland R. . 1998 Oncogene 17: 1053–1059.

  • Meredith SD, Levine PA, Burns JA, Gaffey MJ, Boyd JC, Weiss LM and Erickson NL. . 1995 Arch. Otolaryngol. Head Neck Surg. 121: 790–794.

  • Old LJ and Chen YT. . 1998 J. Exp. Med. 187: 1163–1167.

  • Patel AS, Schechter GL, Wasilenko WJ and Somers KD. . 1998 Oncogene 16: 3227–3232.

  • Rosenberg SA. . 1999 Immunity 10: 281–287.

  • Sahin U, Tureci O, Schmitt H, Cochlovius B, Johannes T, Schmits R, Stenner F, Luo G, Schobert I and Pfreundschuh M. . 1995 Proc. Natl. Acad. Sci. USA 92: 11810–11813.

  • Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M and Old LJ. . 1998 Int. J. Cancer 76: 652–658.

  • Schuuring E, van Damme H, Schuuring-Scholtes E, Verhoeven E, Michalides R, Geelen E, de Boer C, Brok H, van Buuren V and Kluin P. . 1998 Cell. Adhes. Commun. 6: 185–209.

  • Schuuring E, Verhoeven E, Litvinov S and Michalides RJ. . 1993 Mol. Cell. Biol. 13: 2891–2898.

  • Schuuring E, Verhoeven E, van Tinteren H, Peterse JL, Nunnink B, Thunnissen FB, Devilee P, Cornelisse CJ, van de Vijver MJ, Mooi WJ and Michalides . 1992 Cancer Res. 52: 5229–5234.

  • Schuuring E. . 1995 Gene 159: 83–96.

  • van Damme H, Brok H, Schuuring-Scholtes E and Schuuring E. . 1997 J. Biol. Chem. 272: 7374–7380.

  • van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A and Boon T. . 1991 Science 254: 1643–1647.

  • Wu H, Reynolds AB, Kanner SB, Vines RR and Parsons JT. . 1991 Mol. Cell. Biol 11: 5113–5124.

Download references

Acknowledgements

This work was supported by the Ludwig Institute for Cancer Research, Russian Foundation for Basic Research and Russian Human Genome Program and from the Cancer Research Institute fellowship to MA Lagarkova. We are greatly indebted to Drs LJ Old and MJ Scanlan for their continuing help in establishing SEREX methodology in our laboratory and for many helpful discussions. We thank EP Koroleva, RS Kazaryan, DV Kuprash and AN Kuimov from our laboratory for assistance and discussions, A Boudilov for DNA sequencing, RL Turetskaya for critical reading of the manuscript and helpful comments and Prof MR Lichinitser (Oncological Scientific Center, Moscow) for valuable advice.

Author information

Authors and Affiliations

  1. Laboratory of Molecular Immunology, Belozersky Institute of Physico-Chemical Biology, Center for Molecular Medicine, Moscow State University, Moscow, 119899, Russia

    Maria A Lagarkova, Veronica E Boitchenko, Ulyana A Kashkarova & Sergei A Nedospasov

  2. Oncological Scientific Center, Russian Academy of Medical Sciences, Moscow, Russia

    Andrei A Mescheryakov

  3. Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 117984, Russia

    Sergei A Nedospasov

Authors
  1. Maria A Lagarkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Veronica E Boitchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andrei A Mescheryakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ulyana A Kashkarova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sergei A Nedospasov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lagarkova, M., Boitchenko, V., Mescheryakov, A. et al. Human cortactin as putative cancer antigen. Oncogene 19, 5204–5207 (2000). https://doi.org/10.1038/sj.onc.1203826

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1203826

Keywords

This article is cited by

Search

Advanced search

Quick links