Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Paper
  • Published:

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

Abstract

Members of the IL-6 cytokine family are involved in a variety of biological responses, including the immune response, inflammation, hematopoiesis, and oncogenesis by regulating cell growth, survival, and differentiation. These cytokines use gp130 as a common receptor subunit. The binding of ligand to gp130 activates the JAK/STAT signal transduction pathway, where STAT3 plays a central role in transmitting the signals from the membrane to the nucleus. STAT3 is essential for gp130-mediated cell survival and G1 to S cell-cycle-transition signals. Both c-myc and pim have been identified as target genes of STAT3 and together can compensate for STAT3 in cell survival and cell-cycle transition. STAT3 is also required for gp130-mediated maintenance of the pluripotential state of proliferating embryonic stem cells and for the gp130-induced macrophage differentiation of M1 cells. Furthermore, STAT3 regulates cell movement, such as leukocyte, epidermal cell, and keratinocyte migration. STAT3 also appears to regulate B cell differentiation into antibody-forming plasma cells. Since the IL-6/gp130/STAT3 signaling pathway is involved in both B cell growth and differentiation into plasma cells it is likely to play a central role in the generation of plasma cell neoplasias.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  • Akira S . 1999 Stem Cells 17: 138–146

  • Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M and Kishimoto T . 1994 Cell 77: 63–71

  • Allen JD, Verhoeven E, Domen J, van der Valk M and Berns A . 1997 Oncogene 15: 1133–1141

  • Askew DS, Ashmun RA, Simmons BC and Cleveland JL . 1991 Oncogene 6: 1915–1922

  • Astaldi GC, Janssen MC, Lansdorp P, Willems C, Zeijlemaker WP and Oosterhof F . 1980 J Immunol 125: 1411–1414

  • Barone MV and Courtneidge SA . 1995 Nature 378: 509–512

  • Bellido T, O'Brien CA, Roberson PK and Manolagas SC . 1998 J Biol Chem 273: 21137–21144

  • Besser D, Bromberg JF, Darnell Jr JE and Hanafusa H . 1999 Mol Cell Biol 19: 1401–1409

  • Betz UAK, Bloch W, van den Broek M, Yoshida K, Taga T, Kishimoto T, Addicks K, Rajewsky K and Muller W . 1998 J Exp Med 188: 1955–1965

  • Birge RB, Knudsen BS, Besser D and Hanafusa H . 1996 Genes Cells 1: 595–613

  • Boeuf H, Hauss C, Graeve FD, Baran N and Kedinger C . 1997 J Cell Biol 138: 1207–1217

  • Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD and Greenberg ME . 1997 Science 278: 477–483

  • Breuer M, Slebos R, Verbeek S, van Lohuizen M, Weintjens E and Berns A . 1989 Nature 340: 61–63

  • Bromberg JF, Horvath CM, Besser D, Lathem WW and Darnell Jr JE . 1998 Mol Cell Biol 18: 2553–2558

  • Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C and Darnell Jr JE . 1999 Cell 98: 295–303

  • Carlesso N, Frank DA and Griffin JD . 1996 J Exp Med 183: 811–820

  • Catlett-Falcone R, Landowski TH, Oshiro MM, Turkson J, Levitzki A, Savino R, Ciliberto G, Moscinski L, Fernandez-Luna JL, Nunez G, Dalton WS and Jove R . 1999 Immunity 10: 105–115

  • Chapman RS, Lourenco PC, Tonner E, Flint DJ, Selbert S, Takeda K, Akira S, Clarke AR and Watson CJ . 1999 Genes Dev 13: 2604–2616

  • Chen RH, Chang MC, Su YH, Tsai YT and Kuo ML . 1999 J Biol Chem 274: 23013–23019

  • Chin YE, Kitagawa M, Su WC, You ZH, Iwamoto Y and Fu XY . 1996 Science 272: 719–722

  • Chung CD, Liao J, Liu B, Rao X, Jay P, Berta P and Shuai K . 1997 Science 278: 1803–1805

  • Cleveland JL, Dean M, Rosenberg N, Wang JY and Rapp UR . 1989 Mol Cell Biol 9: 5685–5695

  • Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V and Taub R . 1996 Science 274: 1379–1383

  • Cuypers HT, Selten G, Quint W, Zijlstra M, Maandag ER, Boelens W, van Wezenbeek P, Melief C and Berns A . 1984 Cell 37: 141–150

  • Daeipour M, Kumar G, Amaral MC and Nel AE . 1993 J Immunol 150: 4743–4753

  • Dai RM, Chen E, Longo DL, Gorbea CM and Li CC . 1998 J Biol Chem 273: 3562–3573

  • Danial NN, Losman JA, Lu T, Yip N, Krishnan K, Krolewski J, Goff SP, Wang JY and Rothman PB . 1998 Mol Cell Biol 18: 6795–6804

  • Danial NN, Pernis A and Rothman PB . 1995 Science 269: 1875–1877

  • Darnell Jr JE . 1997 Science 277: 1630–1635

  • Darnell Jr JE, Kerr IM and Stark GR . 1994 Science 264: 1415–1421

  • Ernst M, Novak U, Nicholson SE, Layton JE and Dunn AR . 1999 J Biol Chem 274: 9729–9737

  • Escary JL, Perreau J, Dumenil D, Ezine S and Brulet P . 1993 Nature 363: 361–364

  • Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ and Hancock DC . 1992 Cell 69: 119–128

  • Frohlich KU, Fries HW, Peters JM and Mecke D . 1995 Biochim Biophys Acta 1253: 25–32

  • Frohlich KU, Fries HW, Rudiger M, Erdmann R, Botstein D and Mecke D . 1991 J Cell Biol 114: 443–453

  • Fukada T, Hibi M, Yamanaka Y, Takahashi-Tezuka M, Fujitani Y, Yamaguchi T, Nakajima K and Hirano T . 1996 Immunity 5: 449–460

  • Fukada T, Ohtani T, Yoshida Y, Shirogane T, Nishida K, Nakajima K, Hibi M and Hirano T . 1998 EMBO J 17: 6670–6677

  • Galaktionov K, Chen X and Beach D . 1996 Nature 382: 511–517

  • Ghislain M, Dohmen RJ, Levy F and Varshavsky A . 1996 EMBO J 15: 4884–4899

  • Giordano V, De Falco G, Chiari R, Quinto I, Pelicci PG, Bartholomew L, Delmastro P, Gadina M and Scala G . 1997 J Immunol 158: 4097–4103

  • Gires O, Kohlhuber F, Kilger E, Baumann M, Kieser A, Kaiser C, Zeidler R, scheffer B, Ueffing M and Hammerschmidt W . 1999 EMBO J 18: 3064–3073

  • Haegeman G, Content J, Volckaert G, Derynck R, Tavernier J and Fiers W . 1986 Eur J Biochem 159: 625–632

  • Hanissian SH and Geha RS . 1997 Immunity 6: 379–387

  • Heinrich PC, Behrmann I, Muller-Newen G, Schaper F and Graeve L . 1998 Biochem J 334: 297–314

  • Heinrich PC, Castell JV and Andus T . 1990 Biochem J 265: 621–636

  • Heldin CH . 1995 Cell 80: 213–223

  • Heldin CH, Miyazono K and ten Dijke P . 1997 Nature 390: 465–471

  • Henriksson M and Luscher B . 1996 Adv Cancer Res 68: 109–182

  • Hibi M, Murakami M, Saito M, Hirano T, Taga T and Kishimoto T . 1990 Cell 63: 1149–1157

  • Hilbert DM, Kopf M, Mock BA, Kohler G and Rudikoff S . 1995a J Exp Med 182: 243–248

  • Hilbert DM, Migone TS, Kopf M, Leonard WJ and Rudikoff S . 1996 Immunity 5: 81–89

  • Hilbert DM, Shen MY, Rapp UR and Rudikoff S . 1995b Proc Natl Acad Sci USA 92: 649–653

  • Hirano T . 1991 Int J Cell Cloning 9: 166–184

  • Hirano T . 1998 Int Rev Immunol 16: 249–284

  • Hirano T . 1999 Biochem Biophys Res Commun 260: 303–308

  • Hirano T and Kishimoto T . 1990 In Handbook of Experimental Pharmacology, vol 95 Sporn MB and Roberts AB eds Springer Berlin pp 633–665

  • Hirano T, Nakajima K and Hibi M . 1997 Cytokine Growth Factor Rev 8: 241–252

  • Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K, Nakajima K, Pyun KH and Kishimoto T . 1985 Proc Natl Acad Sci USA 82: 5490–5494

  • Hirano T, Teranishi T, Lin B and Onoue K . 1984 J Immunol 133: 798–802

  • Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A et al. 1986 Nature 324: 73–76

  • Hirota H, Chen J, Betz UA, Rajewsky K, Gu Y, Ross Jr J, Muller W and Chien KR . 1999 Cell 97: 189–198

  • Hunter T . 1997 Cell 88: 333–346

  • Ihara S, Nakajima K, Fukada T, Hibi M, Nagata S, Hirano T and Fukui Y . 1997 EMBO J 16: 5345–5352

  • Ihle JN . 1996 Cell 84: 331–334

  • Ihle JN and Kerr IM . 1995 Trends Genet 11: 69–74

  • Jaster R, Tschirch E, Bittorf T and Brock J . 1999 Cell Signal 11: 331–335

  • Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, Nakashima K, Taga T, Yoshida K, Kishimoto T and Miyajima A . 1999 EMBO J 18: 2127–2136

  • Kaplan MH, Daniel C, Schindler U and Grusby MJ . 1998 Mol Cell Biol 18: 1996–2003

  • Kaplan MH, Sun YL, Hoey T and Grusby MJ . 1996 Nature 382: 174–177

  • Karras JG, Wang Z, Huo L, Howard RG, Frank DA and Rothstein TL . 1997 J Exp Med 185: 1035–1042

  • Kawahara A, Minami Y, Miyazaki T, Ihle JN and Taniguchi T . 1995 Proc Natl Acad Sci USA 92: 8724–8728

  • Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H et al. 1988 Nature 332: 83–85

  • Kim H, Hawley TS, Hawley RG and Baumann H . 1998 Mol Cell Biol 18: 1525–1533

  • Kiuchi N, Nakajima K, Ichiba M, Fukada T, Narimatsu M, Mizuno K, Hibi M and Hirano T . 1999 J Exp Med 189: 63–73

  • Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU and Jentsch S . 1999 Cell 96: 635–644

  • Kojima H, Nakajima K and Hirano T . 1996 Oncogene 12: 547–554

  • Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, Zinkernagel R, Bluethmann H and Kohler G . 1994 Nature 368: 339–342

  • Kopf M, Herren S, Wiles MV, Pepys MB and Kosco-Vilbois MH . 1998 J Exp Med 188: 1895–1906

  • Kuchino Y, Nemoto K, Kawai S and Nishimura S . 1985 Jpn J Cancer Res 76: 75–78

  • Kumanogoh A, Marukawa S, Kumanogoh T, Hirota H, Yoshida K, Lee IS, Yasui T, Taga T and Kishimoto T . 1997 Proc Natl Acad Sci USA 94: 2478–2482

  • Largaespada DA, Kaehler DA, Mishak H, Weissinger E, Potter M, Mushinski JF and Risser R . 1992 Oncogene 7: 811–819

  • Lilly M, Le T, Holland P and Hendrickson SL . 1992 Oncogene 7: 727–732

  • Lutticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur AG, Wilks AF, Yasukawa K, Taga T et al. 1994 Science 263: 89–92

  • Madeo F, Frohlich E and Frohlich KU . 1997 J Cell Biol 139: 729–734

  • Marshall CJ . 1995 Cell 80: 179–185

  • Marx JL . 1988 Science 239: 25–26

  • Massague J . 1996 Cell 85: 947–950

  • Masu Y, Wolf E, Holtmann B, Sendtner M, Brem G and Thoenen H . 1993 Nature 365: 27–32

  • Matikainen S, Sareneva T, Ronni T, Lehtonen A, Koskinen PJ and Julkunen I . 1999 Blood 93: 1980–1991

  • Matsuda T, Nakamura T, Nakao K, Arai T, Katsuki M, Heike T and Yokota T . 1999 EMBO J 18: 4261–4269

  • Matsuda T, Yamanaka Y and Hirano T . 1994 Biochem Biophys Res Commun 200: 821–828

  • Matsumura I, Kitamura T, Wakao H, Tanaka H, Hashimoto K, Albanese C, Downward J, Pestell RG and Kanakura Y . 1999 EMBO J 18: 1367–1377

  • Metcalf D . 1989 Lancet 1: 825–827

  • Migone TS, Lin JX, Cereseto A, Mulloy JC, O'Shea JJ, Franchini G and Leonard WJ . 1995 Science 269: 79–81

  • Minami M, Inoue M, Wei S, Takeda K, Matsumoto M, Kishimoto T and Akira S . 1996 Proc Natl Acad Sci USA 93: 3963–3966

  • Minami Y, Nakagawa Y, Kawahara A, Miyazaki T, Sada K, Yamamura H and Taniguchi T . 1995 Immunity 2: 89–100

  • Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A and Kuchino Y . 1999 J Biol Chem 274: 18659–18666

  • Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Duersen J, Sangster MY, Bunting KD, Grosveld GC and Ihle JN . 1999 Immunity 10: 249–259

  • Mui AL, Wakao H, Kinoshita T, Kitamura T and Miyajima A . 1996 EMBO J 15: 2425–2433

  • Murakami-Mori K, Mori S, Taga T, Kishimoto T and Nakamura S . 1997 J Immunol 158: 5518–5526

  • Nakajima K, Yamanaka Y, Nakae K, Kojima H, Ichiba M, Kiuchi N, Kitaoka T, Fukada T, Hibi M and Hirano T . 1996 EMBO J 15: 3651–3658

  • Nakashima K, Wiese S, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Yoshida K, Kishimoto T, Sendtner M and Taga T . 1999a J Neurosci 19: 5429–5434

  • Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K and Taga T . 1999b Science 284: 279–482

  • Narimatsu M, Nakajima K, Ichiba M and Hirano T . 1997 Biochem Biophys Res Commun 238: 764–768

  • Nishida K, Yoshida Y, Itoh M, Fukada T, Ohtani T, Shirogane T, Atsumi T, Takahashi-Tezuka M, Ishihara K, Hibi M and Hirano T . 1999 Blood 93: 1809–1816

  • Niwa H, Burdon T, Chambers I and Smith A . 1998 Genes Dev 12: 2048–2060

  • Nordan RP and Potter M . 1986 Science 233: 566–569

  • Nordan RP, Pumphrey JG and Rudikoff S . 1987 J Immunol 139: 813–817

  • Ogata A, Chauhan D, Teoh G, Treon SP, Urashima M, Schlossman RL and Anderson KC . 1997 J Immunol 159: 2212–2221

  • Ohtani T, Ishihara K, Atsumi T, Nishida K, Kaneko Y, Miyata T, Itoh S, Narimatsu M, Maeda H, Fukada T, Itoh M, Okano H, Hibi M and Hirano T . 2000 Immunity 12: 95–105

  • Paul WE and Seder RA . 1994 Cell 76: 241–251

  • Pawson T and Scott JD . 1997 Science 278: 2075–2080

  • Poli V, Balena R, Fattori E, Markatos A, Yamamoto M, Tanaka H, Ciliberto G, Rodan GA and Costantini F . 1994 EMBO J 13: 1189–1196

  • Potter M and Boyce C . 1962 Nature 193: 1086–1087

  • Potter M, Wax JS and Blankenhorn E . 1985 Curr Top Microbiol Immunol 122: 234–241

  • Ramsay AJ, Husband AJ, Ramshaw IA, Bao S, Matthaei KI, Koehler G and Kopf M . 1994 Science 264: 561–563

  • Romani L, Mencacci A, Cenci E, Spaccapelo R, Toniatti C, Puccetti P, Bistoni F and Poli V . 1996 J Exp Med 183: 1345–1355

  • Romano M, Sironi M, Toniatti C, Polentarutti N, Fruscella P, Ghezzi P, Faggioni R, Luini W, van Hinsbergh V, Sozzani S, Bussolino F, Poli V, Ciliberto G and Mantovani A . 1997 Immunity 6: 315–325

  • Sakamaki K, Miyajima I, Kitamura T and Miyajima A . 1992 EMBO J 11: 3541–3549

  • Sano S, Itami S, Takeda K, Tarutani M, Yamaguchi Y, Miura H, Yoshikawa K, Akira S and Takeda J . 1999 EMBO J 18: 4657–4668

  • Sato N, Sakamaki K, Terada N, Arai K and Miyajima A . 1993 EMBO J 12: 4181–4189

  • Schlessinger J and Bar-Sagi D . 1994 Cold Spring Harb Symp Quant Biol 59: 173–179

  • Sehgal PB, Grieninger G and Tosato G . 1989 Ann New York Acad Sciencies 557: 1–583

  • Shimozaki K, Nakajima K, Hirano T and Nagata S . 1997 J Biol Chem 272: 25184–25189

  • Shirogane T, Fukada T, Muller JMM, Shima DT, Hibi M and Hirano T . 1999 Immunity 11: 709–719

  • Socolovsky M, Fallon AE, Wang S, Brugnara C and Lodish HF . 1999 Cell 98: 181–191

  • Sovova V, Friis R, Fidlerova H and Hlozanek I . 1993 Int J Cancer 53: 983–987

  • Stahl N, Boulton TG, Farruggella T, Ip NY, Davis S, Witthuhn BA, Quelle FW, Silvennoinen O, Barbieri G, Pellegrini S et al. 1994 Science 263: 92–95

  • Stahl N, Farruggella TJ, Boulton TG, Zhong Z, Darnell Jr JE and Yancopoulos GD . 1995 Science 267: 1349–1353

  • Stewart MJ, Litz-Jackson S, Burgess GS, Williamson EA, Leibowitz DS and Boswell HS . 1995 Leukemia 9: 1499–1507

  • Su L, Rickert RC and David M . 1999 J Biol Chem 274: 31770–31774

  • Suematsu S, Matsuda T, Aozasa K, Akira S, Nakano N, Ohno S, Miyazaki J, Yamamura K, Hirano T and Kishimoto T . 1989 Proc Natl Acad Sci USA 86: 7547–7551

  • Suematsu S, Matsusaka T, Matsuda T, Ohno S, Miyazaki J, Yamamura K, Hirano T and Kishimoto T . 1992 Proc Natl Acad Sci USA 89: 232–235

  • Symes A, Stahl N, Reeves SA, Farruggella T, Servidei T, Gearan T, Yancopoulos G and Fink JS . 1997 Curr Biol 7: 697–700

  • Takahashi-Tezuka M, Yoshida Y, Fukada T, Ohtani T, Yamanaka Y, Nishida K, Nakajima K, Hibi M and Hirano T . 1998 Mol Cell Biol 18: 4109–4117

  • Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T and Akira S . 1998 J Immunol 161: 4652–4660

  • Takeda K, Noguchi K, Shi W, Tanaka T, Matsumoto M, Yoshida N, Kishimoto T and Akira S . 1997 Proc Natl Acad Sci USA 94: 3801–3804

  • Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T and Akira S . 1996 Nature 380: 627–630

  • Taniguchi T . 1995 Science 268: 251–255

  • Teranishi T, Hirano T, Arima N and Onoue K . 1982 J Immunol 128: 1903–1908

  • Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC and Ihle JN . 1996 Nature 382: 171–174

  • Thomson A ed . 1998 In The Cytokine Handbook, 3rd edn Academic Press New York

  • Troppmair J, Potter M, Wax JS and Rapp UR . 1989 Proc Natl Acad Sci USA 86: 9941–9945

  • Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP and Jove R . 1998 Mol Cell Biol 18: 2545–2552

  • Uchida J, Yasui T, Takaoka-Shichijo Y, Muraoka M, Kulwichit W, Raab-Traub N and Kikutani H . 1999 Science 286: 300–303

  • Van Damme J, Opdenakker G, Simpson RJ, Rubira MR, Cayphas S, Vink A, Billiau A and Van Snick J . 1987 J Exp Med 165: 914–919

  • van der Lugt NM, Domen J, Verhoeven E, Linders K, van der Gulden H, Allen J and Berns A . 1995 EMBO J 14: 2536–2544

  • van Lohuizen M, Verbeek S, Krimpenfort P, Domen J, Saris C, Radaszkiewicz T and Berns A . 1989 Cell 56: 673–682

  • van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H and Berns A . 1991 Cell 65: 737–752

  • Van Snick J . 1990 Annu Rev Immunol 8: 253–278

  • Van Snick J, Cayphas S, Vink A, Uyttenhove C, Coulie PG, Rubira MR and Simpson RJ . 1986 Proc Natl Acad Sci USA 83: 9679–9683

  • Ward AC, Smith L, de Koning JP, van Aesch Y and Touw IP . 1999 J Biol Chem 274: 14956–14962

  • Watanabe S, Itoh T and Arai K . 1996 J Biol Chem 271: 12681–12686

  • Wu D, Chen PJ, Chen S, Hu Y, Nunez G and Ellis RE . 1999 Development 126: 2021–2031

  • Yamanaka Y, Nakajima K, Fukada T, Hibi M and Hirano T . 1996 EMBO J 15: 1557–1565

  • Yanagisawa M, Nakashima K and Taga T . 1999 Neurosci Lett 269: 169–172

  • Yoshida K, Taga T, Saito M, Suematsu S, Kumanogoh A, Tanaka T, Fujiwara H, Hirata M, Yamagami T, Nakahata T, Hirabayashi T, Yoneda Y, Tanaka K, Wang WZ, Mori C, Shiota K, Yoshida N and Kishimoto T . 1996 Proc Natl Acad Sci USA 93: 407–411

  • Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J and Jove R . 1995 Science 269: 81–83

  • Zhang X, Wrzeszczynska MH, Horvath CM and Darnell Jr JE . 1999 Mol Cell Biol 19: 7138–7146

  • Zhang Z, Jones S, Hagood JS, Fuentes NL and Fuller GM . 1997 J Biol Chem 272: 30607–30610

  • Zilberstein A, Ruggieri R, Korn JH and Revel M . 1986 EMBO J 5: 2529–2537

Download references

Acknowledgements

We would like to thank all members of our laboratory for their excellent contributions to our studies and valuable comments and discussions. We also thank Ms R Masuda and Ms A Kubota for their secretarial assistance. The work performed in our laboratory was supported by grants and a Grant-in-Aid for COE Research from the Ministry of Education, Science, Sports, and Culture in Japan, and grants from the Osaka Foundation for the Promotion of Clinical Immunology.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hirano, T., Ishihara, K. & Hibi, M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19, 2548–2556 (2000). https://doi.org/10.1038/sj.onc.1203551

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1203551

Keywords

This article is cited by

Search

Quick links