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Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes

Oncogene volume 19, pages 2557–2565 (2000)Cite this article

Abstract

Cells of the immune system communicate with each other to initiate, establish and maintain immune responses. The communication occurs through cell-to-cell contact or through a variety of intercellular mediators that include cytokines, chemokines, growth factors and hormones. In the case of cytokines, the signal is transmitted from the outside to the inside of a cell through cell surface receptors specific for each cytokine. At this step the signal is also decoded and amplified: ligand binding causes recruitment and/or activation of numerous cytoplasmic proteins. One cytokine can activate a number of signal transduction pathways leading to regulation of a wide array of biological activities. One of these pathways, the Jak-Stat pathway, is briefly reviewed here with respect to the class II cytokine receptors. Signal transduction through receptors for interferons Type I (IFN-α, IFN-β, IFN-ω) and Type II (IFN-γ), and interleukin 10 (IL-10) is described in detail. In addition, a complex between tissue factor (TF) and coagulation factor VIIa, and two new receptors related to the class II cytokine receptor family are discussed.

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Abbreviations

EpoR:

Erythropoietin receptor

GHR:

growth hormone receptor

ProR:

prolactin receptor

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Acknowledgements

We thank Eleanor Kells for assistance in the preparation of the manuscript and Jerome Langer and Michael Newlon for the critical review of the text. This study was supported in part by American Heart Association Grant AHA#9730247N and by State of New Jersey Commission on Cancer Research Grant#799-021 to SV Kotenko, and by United States Public Health Services Grants RO1-CA46465 and 1P30-CA72720 from the National Cancer Institute, RO1 AI36450 and RO1 AI43369 from the National Institute of Allergy and Infectious Diseases and an award from the Milstein Family Foundation to S Pestka.

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  1. Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, 08854-5635, New Jersey, NJ, USA

    Sergei V Kotenko & Sidney Pestka

  2. Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, 08901, New Jersey, NJ, USA

    Sidney Pestka

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Kotenko, S., Pestka, S. Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes. Oncogene 19, 2557–2565 (2000). https://doi.org/10.1038/sj.onc.1203524

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