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The p53 gene family

Oncogene volume 18, pages 7701–7705 (1999)Cite this article

Abstract

p73 and p63 are two recently discovered p53 homologs. Like p53, these proteins can recognize canonical p53 DNA-binding sites and, when overproduced, can activate p53-responsive target genes and induce apoptosis. Unlike p53, these genes undergo complex alternative splicing which, at least in the case of p63, yields proteins with widely divergent biological properties. In addition p73 and p63 are, in contrast to p53, rarely mutated in human cancer. Furthermore, p73 inactivation is not required for viral transformation. Thus, there is currently no firm evidence that p63 and p73 should be considered tumor suppressors. The early suggestion that monoallelic expression of p73 contributed to carcinogenesis needs to be interpreted cautiously in light of data showing interindividual and intraindividual variation with respect to monoallelic expression of p73 and the finding that p73 mRNA levels are generally increased, rather than decreased, in a host of tumors relative to normal cells.

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Acknowledgements

I thank Drs Maria Carmen Marin and Meredith Irwin for critical reading of the manuscript and useful comments. I apologize to colleagues whose work was not cited due to space limitations or oversight. Please bring egregious omissions or errors to my attention at: william_kaelin@dfci.harvard.edu.

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  1. Howard Hughes Medical Institute and Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, Massachusetts, MA, USA

    William G Kaelin Jr

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Kaelin, W. The p53 gene family. Oncogene 18, 7701–7705 (1999). https://doi.org/10.1038/sj.onc.1202955

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