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The v-myc oncogene

Oncogene volume 18, pages 2997–3003 (1999)Cite this article

Abstract

v-myc is the viral homolog of c-myc transduced by several acute transforming retroviruses, many of which encode this gene as a Gag-Myc fusion protein. The v-myc oncogene can transform several lineages of mammalian and avian cells either alone or in co-operation with other oncogenes. While the Gag portion of the Gag-Myc fusion protein and the nuclear localization signal each appear to be dispensable for transformation, the N- and C-termini of the Myc sequence have been found to be essential for transformation. All v-myc genes contain point mutations which seem to confer a greater potency to v-myc in the process of transformation, proliferation, and apoptosis. In v-myc-transformed myelomonocytic cells, secondary events occur, such as the expression of colony stimulating factor-1 (CSF-1) which play a critical role in immortalization and subsequent tumor progression. Inhibition of the autocrine loop of CSF-1 was found to induce apoptosis in the immortalized cells. While overexpression of v-Myc blocks terminal differentiation of hematopoietic cells, this is not sufficient to block the differentiation of certain neural and skeletal muscle cells. Recent developments on the effects of v-myc on cell growth, transformation, differentiation and apoptosis are discussed in this review.

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  1. Fels Institute for Cancer Research and Molecular Biology, School of Medicine, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, Pennsylvania, USA

    Clement M Lee & E Premkumar Reddy

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  1. Clement M Lee
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Lee, C., Reddy, E. The v-myc oncogene. Oncogene 18, 2997–3003 (1999). https://doi.org/10.1038/sj.onc.1202786

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