Abstract
THE fact that a diet of mammalian thyroid will induce frog-tadpoles to metamorphose precociously into the adult form is now well established. It is of some interest to find that this diet produces a similar effect in a form which usually does not metamorphose—the Axolotl. This is the larva of a salamander known as Amblystoma, but is remarkable in being neotenic, i.e. it normally fails to metamorphose, and attains full size and sexual maturity while keeping its larval characters. Chief among these are the external gills and the fin along the back and both borders of the tail, but the adult also differs from the larva in colour, in shape of head, in the development of eyes and eyelids, in the rounded form of the tail, and, of course, in the use of its limbs for progression on land.
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HUXLEY, J. Metamorphosis of Axolotl caused by Thyroid-feeding. Nature 104, 435 (1920). https://doi.org/10.1038/104435b0
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DOI: https://doi.org/10.1038/104435b0
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