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Correlation between angiotensinogen gene polymorphisms and essential hypertension in Chinese population

Journal of Human Hypertension volume 22, pages 147–150 (2008)Cite this article

Essential hypertension (EHT) has a genetic basis. Considering the pathological, physiological and biological mechanisms implicated in blood pressure regulation, many candidates have been listed as hypertension genes, of which the angiotensinogen gene ( AGT ) is weighed as the most promising one.

In 1992, Jeunemaitre et al.1 first reported a linkage between genetic variants of AGT and EHT in humans, and found that the M235T mutation in exon 2 of AGT associated both elevated angiotensinogen concentrations and high hypertension risk. Later on, extensive association studies regarding genetic variants of AGT and EHT have been conducted, with inconsistent results. Several comprehensive meta-analyses, however, convincingly demonstrated a significant association between M235T and hypertension, with 235T allele conferring a combined relative risk of ∼1.2.2, 3 Other polymorphisms in AGT such as A-20C and A-6G have also been shown to affect either blood pressure or gene expression.4, 5 Thus, well characterizing the role of AGT may be a guide for elucidating the genetic makeup of EHT.

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Author notes

  1. Y Qi and W Niu: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, PR China

    Y Qi, W Niu, W Zhou & C Qiu

  2. Department of Clinical Laboratory, The First Hospital of Fangshan District, Beijing, PR China

    S Hou

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  1. Y Qi
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  2. W Niu
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  3. W Zhou
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Correspondence to C Qiu.

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Qi, Y., Niu, W., Zhou, W. et al. Correlation between angiotensinogen gene polymorphisms and essential hypertension in Chinese population. J Hum Hypertens 22, 147–150 (2008). https://doi.org/10.1038/sj.jhh.1002282

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