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Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men

Journal of Human Hypertension volume 21, pages 966–968 (2007)Cite this article

In a cross-sectional observation on 2133 middle-aged healthy men, serum creatinine was decreased and creatinine clearance (Ccr) calculated by Cockcroft and Gault formula was increased with increases in alcohol and cigarette consumption. Although no association of Ccr with blood pressure (BP) was observed in drinkers without smoking habit, BP was increased with increases in Ccr in smokers irrespective of alcohol consumption. Further studies are required because the combined elevations of Ccr and BP may relate to the progressive deterioration of renal function in hypertensive smokers.

Alcohol consumption is a cause of human hypertension, but the effects of cigarette consumption on BP have remained obscure. Meanwhile, a low serum creatinine concentration has been observed in both alcohol and cigarette consumers. Drinkers showing low serum creatinine were reported to have a high occurrence of death1 and disease2 related to alcohol consumption. On the other hand, since deteriorating effects of cigarette consumption on renal function are well known in patients having kidney diseases,3, 4 the low serum creatinine may have some relation to the renal-toxic effects of cigarette smoking.

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Authors and Affiliations

  1. Department of Social and Environmental Medicine, Kanazawa Medical University, Ishikawa, Japan

    Y Noborisaka, R Honda, M Ishizaki, M Nakata & Y Yamada

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  1. Y Noborisaka
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  2. R Honda
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  3. M Ishizaki
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  4. M Nakata
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  5. Y Yamada
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Correspondence to Y Noborisaka.

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Noborisaka, Y., Honda, R., Ishizaki, M. et al. Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men. J Hum Hypertens 21, 966–968 (2007). https://doi.org/10.1038/sj.jhh.1002242

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