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Non-effect of p22-phox −930A/G polymorphism on end-organ damage in Brazilian hypertensive patients

Journal of Human Hypertension volume 21, pages 504–506 (2007)Cite this article

The p22-phox subunit is an essential component of NAD(P)H oxidase enzymatic complex, which is considered the major source of oxidative stress products in the cardiovascular system.1, 2 The −930G allele of p22-phox has been associated with higher promoter activity, increased NAD(P)H oxidase-mediated oxidative stress and hypertension.3, 4 We recently reported that left ventricular hypertrophy is accompanied by increased myocardial p22-phox expression in aortic-banded rats, suggesting that this protein might be involved in hypertensive cardiac hypertrophy.2 Thus, the aim of the present report was to investigate the role of p22-phox −930A/G polymorphism on end-organ damage in hypertensive patients.

The study was carried out in 194 hypertensive patients followed up at the Hypertension Unit of State University of Campinas and in 70 normotensive volunteers recruited between January 2005 and December 2006. Clinical data were based on medical history, physical examination and routine analytical tests. Echocardiographic evaluation was performed as previously described.5 Genomic DNA was extracted from peripheral blood leucocytes, amplified by polymerase chain reaction and polymorphisms were detected by restriction reaction.3 The study was approved by the Ethics Committee of the State University of Campinas, and informed consent was obtained from all participants. Data are expressed as means±s.e. The statistical significance of differences was analysed by Student's t-test. Comparisons between categoric variables were made by χ2 test.

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Author notes

  1. M L Sales and M C S Ferreira: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Internal Medicine, School of Medicine, State University of Campinas, Cidade Universitária, Campinas, SP, Brazil

    M L Sales, C A Leme Jr, L A Velloso, K G Franchini & W Nadruz Jr

  2. School of Nursing, State University of Campinas, Cidade Universitária, Campinas, SP, Brazil

    M C S Ferreira, M C J Gallani & R C R Colombo

Authors
  1. M L Sales
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  2. M C S Ferreira
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  3. C A Leme Jr
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  4. L A Velloso
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  5. M C J Gallani
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  6. R C R Colombo
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  7. K G Franchini
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  8. W Nadruz Jr
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Correspondence to W Nadruz Jr.

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Sales, M., Ferreira, M., Leme, C. et al. Non-effect of p22-phox −930A/G polymorphism on end-organ damage in Brazilian hypertensive patients. J Hum Hypertens 21, 504–506 (2007). https://doi.org/10.1038/sj.jhh.1002170

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