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Apolipoprotein E and low-density lipoprotein receptor gene polymorphisms in dyslipidemias-associated essential hypertension

Journal of Human Hypertension volume 21, pages 337–339 (2007)Cite this article

Hypertension has been strongly linked to a variety of lipoprotein metabolic abnormalities. Polymorphisms in the genes encoding the lipoproteins involved in metabolic abnormalities are the major target for evaluating the predisposition to the development of hypertension. In this study, two candidate genes including apolipoprotein E (ApoE) and low-density lipoprotein receptor (LDLR) were selected to examine their possible contribution to hypertension in a Chinese Han population.

Hypertension is a complex multifactorial and polygenic disorder that is thought to result from an interaction between an individual's genetic makeup and various environmental factors.1 Given that hypertension is a major risk factor for cardiovascular diseases, stroke and end-stage renal disease and prevails globally, prevention of hypertension is an important public health goal.2 One preventive approach is to identify disease-susceptibility genes that involve a specific physiological or cellular function.

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Authors and Affiliations

  1. The Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China

    W Niu & C Qiu

  2. The Clinical Medical Research Center of Hebei General Hospital, Shijiazhuang City, Hebei province, China

    X Guo & Y Su

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  1. W Niu
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  2. X Guo
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  3. Y Su
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  4. C Qiu
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Niu, W., Guo, X., Su, Y. et al. Apolipoprotein E and low-density lipoprotein receptor gene polymorphisms in dyslipidemias-associated essential hypertension. J Hum Hypertens 21, 337–339 (2007). https://doi.org/10.1038/sj.jhh.1002151

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