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Both angiotensinogen M235T and α-adducin G460W polymorphisms are associated with hypertension in the Japanese population

Journal of Human Hypertension volume 21, pages 253–255 (2007)Cite this article

Both the angiotensinogen M235T and the α -adducin G460W polymorphisms have been reported to be linked to sodium retention. We studied the association between these polymorphisms and hypertension on a large-scale community-based population in Japan, and found that the two polymorphisms were associated with hypertension, independent of classical hypertension risk factors in the Japanese.

The angiotensinogen M235T located at 1q42–q43 and the α-adducin G460W at 4p16.3 polymorphisms were reported to be associated with hypertension and to be linked to sodium retention.1, 2 Despite the several earlier reports, later studies on the association between these polymorphisms and hypertension reported conflicting results.3, 4, 5, 6, 7, 8

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Authors and Affiliations

  1. Cardiovascular Epidemiology, Kyoto Women's University, Higashiyama-ku, Kyoto, Japan

    Y Nakamura

  2. Department of Environmental Health and Social Science, National University Corporation Ehime University School of Medicine, Toon, Japan

    Y Tabara

  3. Department of Geriatric Medicine, National University Corporation Ehime University School of Medicine, Toon, Japan

    T Miki

  4. Department of Medicine, Kohka Public Hospital, Kohka, Japan

    S Tamaki

  5. Department of Health Science, Shiga University of Medical Science, Otsa, Japan

    Y Kita, T Okamura & H Ueshima

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  1. Y Nakamura
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  2. Y Tabara
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  3. T Miki
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  4. S Tamaki
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  6. T Okamura
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  7. H Ueshima
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Correspondence to Y Nakamura.

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Nakamura, Y., Tabara, Y., Miki, T. et al. Both angiotensinogen M235T and α-adducin G460W polymorphisms are associated with hypertension in the Japanese population. J Hum Hypertens 21, 253–255 (2007). https://doi.org/10.1038/sj.jhh.1002135

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