Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Exercise blood pressure in young adults as a predictor of future blood pressure: a 12-year follow-up of medical school graduates

Abstract

It has not been fully clarified whether exercise blood pressure (BP) in young adult men and women is useful to predict future BP, especially in Asian people. A long-term prospective study was conducted in graduates of a medical school in Japan; 138 men and 76 women whose mean age was 19.8 and 19.2, respectively, at baseline. A 5-min exercise tolerance test was performed at baseline, and BP immediately after exercise was measured. BP at 50% intensity exercise was also calculated. Multiple regression analysis was carried out to clarify the relationship of exercise BP at baseline to follow-up BP after an average of 12 years. In multivariate-adjusted models, the relationship of systolic blood pressure (SBP) at follow-up was stronger to SBP immediately after exercise (F=7.7, P=0.006) than to resting SBP (F=3.7, P=0.055) in men. The models in men showed that SBP immediately after exercise was a stronger predictor of follow-up SBP than SBP at 50% intensity exercise, and the results were similar for diastolic blood pressure (DBP) in men. For SBP in women, resting SBP was the strongest predictor of follow-up SBP (F=14.3, P<0.001), and exercise SBP was not significant predictor. For DBP in women, any DBP at rest or after exercise was not significantly related to DBP at follow-up. In young adult men, SBP and DBP immediately after exercise would be a stronger predictor of future SBP and DBP rather than BP at rest. However, in young adult women, resting SBP rather than exercise SBP would be better to predict future SBP.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Miura K et al. Relationship of blood pressure to 25-year mortality due to coronary heart disease, cardiovascular diseases, and all causes in young adult men: The Chicago Heart Association Detection Project in Industry. Arch Intern Med 2001; 161: 1501–1508.

    Article  CAS  Google Scholar 

  2. McCarron P, Smith GD, Okaha M, McEwen J . Blood pressure in young adulthood and mortality from cardiovascular disease. Lancet 2000; 355: 1430–1431.

    Article  CAS  Google Scholar 

  3. Vasan RS et al. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med 2001; 345: 1291–1297.

    Article  CAS  Google Scholar 

  4. Singh JP et al. Blood pressure response during treadmill testing as a risk factor for new-onset hypertension: The Framingham Heart Study. Circulation 1999; 99: 1831–1836.

    Article  CAS  Google Scholar 

  5. Matthews CE et al. Exaggerated blood pressure response to dynamic exercise and risk of future hypertension. J Clin Epidemiol 1998; 51: 29–35.

    Article  CAS  Google Scholar 

  6. Miyai N et al. Exercise BP response in subjects with high-normal BP: exaggerated blood pressure response to exercise and risk of future hypertension in subjects with high-normal blood pressure. J Am Coll Cardiol 2000; 36: 1626–1631.

    Article  CAS  Google Scholar 

  7. Tsumura K et al. Blood pressure response after two-step exercise as a powerful predictor of hypertension: The Osaka Health Survey. J Hypertens 2002; 20: 1507–1512.

    Article  CAS  Google Scholar 

  8. Dlin RA, Hanne N, Silverberg DS, Bar-Or O . Follow-up of normotensive men with exaggerated blood pressure response to exercise. Am Heart J 1983; 106: 316–320.

    Article  CAS  Google Scholar 

  9. Manolio TA et al. Exercise blood pressure response and 5-year risk of elevated blood pressure in a cohort of young adults: The CARDIA Study. Am J Hypertens 1994; 7: 234–241.

    Article  CAS  Google Scholar 

  10. Klag MJ et al. Serum cholesterol in young men and subsequent cardiovascular disease. N Engl J Med 1993; 328: 313–318.

    Article  CAS  Google Scholar 

  11. Karvonen MJ, Kentala E, Mustala O . The effects of training on heart rate. Ann Med Exper Biol Fenn 1957; 35: 307–315.

    CAS  Google Scholar 

  12. American College of Sports Medicine Position Stand. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness and flexibility in healthy adults. Med Sci Sport Exer 1998; 30: 975–991.

  13. Drory Y, Pines A, Fisman EZ, Kellermann JJ . Exercise response in young woman with borderline hypertension. Chest 1990; 97: 298–301.

    Article  CAS  Google Scholar 

  14. Lund-Johansen P . Blood pressure response during exercise as a prognostic factor. J Hypertens 2002; 20: 1473–1474.

    Article  CAS  Google Scholar 

  15. MacDonald JR . Potential causes, mechanisms, and implications of post exercise hypotension. J Hum Hypertens 2002; 16: 225–236.

    Article  CAS  Google Scholar 

  16. Sun M, Jones R . Accuracy relationship of blood pressure devices between the AMMI SP 10 standard and the British Hypertension Society protocols. Biomed Instrum Technol 1999; 33: 62–70.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K Miura.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nakashima, M., Miura, K., Kido, T. et al. Exercise blood pressure in young adults as a predictor of future blood pressure: a 12-year follow-up of medical school graduates. J Hum Hypertens 18, 815–821 (2004). https://doi.org/10.1038/sj.jhh.1001749

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jhh.1001749

Keywords

This article is cited by

Search

Quick links