Abstract
Decreased baroreflex sensitivity (BRS) is a prognostic marker in essential hypertension. Animal experiments suggest that decreased BRS is related to increased oxidative stress. Our study was aimed at testing whether oxidative stress, estimated by isoprostane 15-F2t-IsoP urinary levels, is correlated to BRS variation in healthy subjects as well as in patients suffering from essential hypertension. Urinary 15-F2t-IsoP levels and BRS were evaluated in two groups of subjects: healthy volunteers (n=64) and patients with untreated mild-to-moderate hypertension (n=33). Data were analysed in 61 and 31 subjects, respectively, BRS analysis being impossible in three and two subjects, respectively. 15-F2t-IsoP levels were measured using gas chromatography/mass spectrometry. BRS was measured using the sequence method [PS+/RR+ and PS−/RR−] and crossspectral analysis (CSP) (MF gain) at rest, lying down. No significant correlation was found between basal urinary 15-F2t-IsoP levels and BRS (sequence method and CSP) in either healthy controls or hypertensive patients. Our study shows that oxidative stress is not involved in interindividual variations of BRS in healthy subjects and patients suffering from mild-to-moderate hypertension
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References
Parmer RJ, Cervenka JH, Stone RA . Baroreflex sensitivity and heredity in essential hypertension. Circulation 1992; 85: 497–503.
Lucini D, Mela GS, Malliani A, Pagani M . Impairment in cardiac autonomic regulation preceding arterial hypertension in humans: insights from spectral analysis of beat-by-beat cardiovascular variability. Circulation, 2002; 106: 2673–2679.
Parmer RJ, Cervenka JH, Stone RA . Baroreflex sensitivity and heredity in hypertension. Circulation 1992; 85: 497–503.
Algra A et al. Heart rate variability from 24-hour electrocardiography and the 2-year risk for sudden death. Circulation 1993; 88: 180–185.
Siché JP et al. Examination of variability in arterial blood pressure at rest using spectral analysis in hypertensive patients. J Hypertens 1995; 13: 147–153.
Parati G et al. Evaluation of the baroreceptor-heart rate reflex by 24-hour intra-arterial blood pressure monitoring in humans. Hypertension 1988; 12: 214–222.
Frattola A et al. Prognostic value of 24-hour blood pressure variability. J Hypertens 1993; 11: 1133–1137.
Kardos A et al. Determinants of spontaneous baroreflex sensitivity in a healthy working population. Hypertension 2001; 37: 911–916.
Laitinen T et al. Age and gender dependency of baroreflex sensitivity in healthy subjects. J Appl Physiol 1998; 84: 576–583.
Chapleau MW et al. Structural versus functional modulation of the arterial baroreflex. Hypertension 1995; 26: 341–347 (Review).
Li Z et al. Oxygen-derived free radicals contribute to baroreceptor dysfunction in atherosclerotic rabbits. Circ Res 1996; 79: 802–811.
Ziegler D et al. Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Deutsche Kardiale Autonome Neuropathie. Diabetes Care 1997; 20: 369–373.
Manzella D, Barbieri M, Ragno E, Paolisso G . Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes. Am J Clin Nutr 2001; 73: 1052–1057.
Roberts LJ, Morrow JD . Measurement of F2-isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med 2000; 28: 505–513.
Cracowski JL, Durand T, Bessard G . Isoprostanes as a biomarker of lipid peroxidation in humans: physiology, pharmacology and clinical implications. Trends Pharmacol Sci 2002; 23: 360–366.
Morrow JD et al. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. N Engl J Med 1995; 332: 1198–1203.
Reilly MP et al. Increased formation of distinct F2 isoprostanes in hypercholesterolemia. Circulation 1998; 98: 2822–2828.
Davi G et al. In vivo formation of 8-iso-prostaglandin F2a and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation 1999; 99: 224–229.
Cracowski JL et al. Lipid peroxidation is not increased in patients with untreated mild to moderate hypertension. Hypertension 2003; 41: 286–288.
Baguet JP et al. Relationships between cardiovascular remodelling and the pulse pressure in never treated hypertension. J Hum Hypertens 2000; 14: 23–30.
Baguet JP et al. Carotid remodeling in essential hypertension: role of blood pressure, indexed parameters, and association with cardiac mass and aortic stiffness. Clin Exp Hypertens 2000; 22: 717–729.
Herpin D, Ragot S . Mid- and long-term reproducibility of noninvasive measurements of spontaneous arterial baroreflex sensitivity in healthy volunteers. Am J Hypertens 1997; 10: 790–797.
Imholz BPM, Wieling W, Langewouters GJ, Van Montfrans GA . Continuous finger arterial pressure: utility in the cardiovascular laboratory. Clin Auton Res 1991; 1: 43–53.
Herpin D, Ragot S . Mid- and long-term reproducibility of noninvasive measurements of spontaneous arterial baroreflex sensitivity in healthy volunteers. Am J Hypertens 1997; 10: 790–797.
Parati G et al. Evaluation of the baroreceptor-heart rate reflex by 24-hour intra-arterial blood pressure monitoring in humans. Hypertension 1988; 12: 214–222.
Robbe HWJ et al. Assessment of baroreceptor reflex sensitivity by means of spectral analysis. Hypertension 1987; 10: 538–543.
De Boer RW, Karemaker JM, Strackee J . Relationships between short-term blood pressure fluctuations and heart rate variability in resting subjects: a spectral analysis approach. Med Biol Eng Comput 1985; 23: 352–358.
Siché JP et al. Examination of variability in arterial blood pressure at rest using spectral analysis in hypertensive patients. J Hypertens 1995; 1: 147–153.
Bessard J, Cracowski JL, Stanke-Labesque F, Bessard G . Determination of isoprostaglandin F2 α type III in human urine by gas chromatography–electronic impact mass spectrometry. Comparison with enzyme immunoassay. J Chromatogr B 2001; 754: 333–343.
Pagani M, Lucini D . Autonomic dysregulation in essential hypertension: insight from heart rate and arterial pressure variability. Auton Neurosci 2001; 90: 76–82.
Barton CH, Ni Z, Vaziri ND . Enhanced nitric oxide inactivation in aortic coarctation-induced hypertension. Kidney Int 2001; 60: 1083–1087.
Dawson SL et al. The reproducibility of cardiac baroreceptor activity assessed non invasively by spectral and sequence techniques. J Clin Autonom Res 1997; 7: 279–284.
Kardos A et al. Determinants of spontaneous baroreflex sensitivity in a healthy working population. Hypertension 2001; 37: 911–916.
Lantelme P et al. Spontaneous baroreflex sensitivity: toward an ideal index of cardiovascular risk in hypertension? J Hypertens 2002; 20: 935–944.
Siché JP et al. Examination of variability in arterial blood pressure at rest using spectral analysis in hypertensive patients. J Hypertens 1995; 13: 147–153.
Kardos A et al. Determinants of spontaneous baroreflex sensitivity in a healthy working population. Hypertension 2001; 37: 911–916.
Laitinen T et al. Age and gender dependency of baroreflex sensitivity in healthy subjects. J Appl Physiol 1998; 84: 576–583.
Roberts LJ, Morrow JD . Measurement of F2-isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med 2000; 28: 505–513.
Acknowledgements
We acknowledge the technical assistance of Hélène Pierre, Jean-Louis Quesada and Jocelyne Truchet. This work was supported by a grant from the French Society of Hypertension.
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Ormezzano, O., Cracowski, JL., Baguet, JP. et al. Oxidative stress and baroreflex sensitivity in healthy subjects and patients with mild-to-moderate hypertension. J Hum Hypertens 18, 517–521 (2004). https://doi.org/10.1038/sj.jhh.1001684
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DOI: https://doi.org/10.1038/sj.jhh.1001684