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Structural and functional cardiovascular abnormalities in never-treated hypertensives according to ACE-gene polymorphism

Journal of Human Hypertension volume 17, pages 441–443 (2003)Cite this article

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The two allelic forms of the angiotensin-converting enzyme (ACE) gene are characterized by the presence (I) or absence (D) of a 287 base pair repetitive DNA domain in intron 16. ACE gene insertion/deletion (I/D) polymorphism accounts for nearly half the variance of the serum levels of the enzyme in general population. Homozygosity for the D allele (DD) of the ACE gene is the allelic variant associated with higher ACE plasma levels.1 It is still controversial whether the ACE gene polymorphism is associated with arterial hypertension2,3 as well as if the DD homozygosity is associated with left ventricular (LV) hypertrophy4,5.

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References

  1. Rigat B et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343–1346

    Article  CAS  Google Scholar 

  2. Higashimori K et al. Association analysis of a polimorphism of the angiotensin converting enzyme gene with essential hypertension in the Japanese population. Biochem Biophis Res Commun 1993; 191: 399–404

    Article  CAS  Google Scholar 

  3. Kreutz R, Hübner N, Ganten D, Lindpaintner K . Genetic linkage of the ACE gene to plasma angiotensin-converting enzyme activity but not to blood pressure. A quantitative trait locus confers identical complex phenotypes in human and rat hypertension. Circulation 1995; 92: 2381–2384

    Article  CAS  Google Scholar 

  4. Schunkert H et al. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med 1994; 330: 1634–1638

    Article  CAS  Google Scholar 

  5. Lindpaintner K et al. Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. N Engl J Med 1996; 334: 1023–1028

    Article  CAS  Google Scholar 

  6. Castellano M et al. Angiotensin-converting-enzyme I/D polymorphism and arterial wall thickness in a general population — The Vobarno Study. Circulation 1995; 91: 2721–2724

    Article  CAS  Google Scholar 

  7. Ferrara LA et al. Isolated office hypertension and end-organ damage. J Hypertens 1997; 15: 979–985

    Article  CAS  Google Scholar 

  8. Mancini FP et al. A fast and accurate method for genotyping the angiotensin converting enzyme I/D polymorphism. Circulation 1998; 97: 1213–1214

    Article  CAS  Google Scholar 

  9. Ferrara LA et al. Early changes of the arterial carotid wall in uncomplicated primary hypertensive patients. Arterioscler Thromb 1994; 14: 1290–1296.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine Federico II University, Via S. Pansini 5, Naples, 80131, Italy

    L A Ferrara, L Guida, F P Mangini, A Celentano & G D Niano

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  1. L A Ferrara
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  2. L Guida
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  3. F P Mangini
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  4. A Celentano
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  5. G D Niano
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Correspondence to L A Ferrara.

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Ferrara, L., Guida, L., Mangini, F. et al. Structural and functional cardiovascular abnormalities in never-treated hypertensives according to ACE-gene polymorphism. J Hum Hypertens 17, 441–443 (2003). https://doi.org/10.1038/sj.jhh.1001560

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  • DOI: https://doi.org/10.1038/sj.jhh.1001560

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