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Blood rheology in men with essential hypertension and capillary rarefaction

Journal of Human Hypertension volume 16, pages 533–537 (2002)Cite this article

Abstract

The pathophysiological significance of hyperviscosity and capillary rarefaction in untreated essential hypertension is unknown. Fifty untreated hypertensive men with capillary rarefaction (intravital capillaroscopy) and 20 age- and sex-matched normotensive controls underwent full haemorheological profiling (blood viscosity at high and low shear, haematocrit, platelet and leukocyte counts, fibrinogen and total protein concentrations, P-selectin levels, erythrocyte and leukocyte filterability rates and erythrocyte deformability and aggregation indexes). Subjects with skin capillary density below the group median had younger age, higher diastolic pressure, higher blood viscosity at low shear, higher P-selectin levels, higher erythrocyte and leukocyte filterability rates, and higher erythrocyte aggregation indexes (all P < 0.01). In contrast, patients with greater skin capillary density had a greater plasma viscosity (P < 0.05). The conclusions were that in untreated hypertensive men, capillary rarefaction and hyperviscosity are associated to an increased diastolic blood pressure and to an adverse haemorheological profile.

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References

  1. Lowe GDO . Blood rheology in general medicine and surgery Bailliere's Clin Haematol 1987; 1: 827–861

    Article  CAS  Google Scholar 

  2. Letcher RL et al. Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects Am J Med 1981; 70: 1195–1202

    Article  CAS  Google Scholar 

  3. Chien S . Blood rheology in hypertension and cardiovascular disease Cardiovasc Med 1977; 2: 356–360

    Google Scholar 

  4. Harper RN et al. Arteriolar rarefaction in the conjunctiva of human essential hypertensives Microvasc Res 1978; 16: 369–372

    Article  CAS  Google Scholar 

  5. Chen IH et al. Microvascular rarefaction in spontaneously hypertensive rat cremaster muscle Am J Physiol 1981; 241: H306–H310

    CAS  PubMed  Google Scholar 

  6. Antonios TFT et al. Structural skin capillary rarefaction in essential hypertension Hypertension 1999; 33: 998–1001

    Article  CAS  Google Scholar 

  7. Levy BI et al. Microcirculation in hypertension A new target for treatment? Circulation 2001; 104: 735–740

    CAS  PubMed  Google Scholar 

  8. Bagge U, Branemark PI . White blood cell rheology: an intravital study in man In: Altura BM, Davis E,Harders H (eds) Advanced Microcirculation vol 7: Basel Karger 1977; pp 18–28

    Google Scholar 

  9. Cerletti C et al. P-selectin beta2-integrin cross-talk: a molecular mechanism for polymorphonuclear leukocyte recruitment at the site of vascular damage Thromb Haemost 1999; 82: 787–793

    Article  CAS  Google Scholar 

  10. Harkness J . The viscosity of human blood plasma; its measurement in health and disease Biorheology 1971; 8: 171–193

    Article  CAS  Google Scholar 

  11. International Committee for Standardization in Haematology (Expert Panel on Blood Rheology). Guidelines on selection of laboratory tests for monitoring the acute phase response J Clin Pathol 1988; 41: 1203–1212

  12. Mikita J, Nash G, Dormandy J . A simple method of preparing white blood cells for filterability testing Clin Hemorheol 1986; 6: 635–639

    Google Scholar 

  13. Lennie SE et al. Filterability of white blood cell subpopulations, separated by an improved method Clin Hemorheol 1987; 7: 811–816

    Google Scholar 

  14. Nash GB et al. Effects of preparative procedures and of cell activation on flow of white cells through micropore filters Br J Haematol 1988; 70: 171–176

    Article  CAS  Google Scholar 

  15. Chien S . Principles and techniques for assessing erythrocyte deformability Blood Cells 1978; 3: 71–74

    Google Scholar 

  16. Dintenfass L . Hyperviscosity in Hypertension Pergamon Press: Sidney 1981

    Google Scholar 

  17. Blann AD, Lip GYH . Is soluble P-selectin a new marker of platelet activation? Atherosclerosis 1997; 128: 135–138

    Article  CAS  Google Scholar 

  18. Ciuffetti G et al. Peripheral vascular disease. Rheologic variables during controlled Ischemia Circulation 1989; 80: 348–352

    Article  CAS  Google Scholar 

  19. Peeters LLH, Buchan PC . Blood viscosity in perinatology Rev Perinatal Med 1989; 6: 53–89

    Google Scholar 

Download references

Acknowledgements

We gratefully thank Mrs Geraldine Anne Boyd for her editorial assistance.

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, Section of Internal Medicine, Angiology and Atherosclerosis Disease, University of Perugia Monteluce Hospital, Perugia, Italy

    G Ciuffetti, L Pasqualini, M Pirro, R Lombardini, M De Sio, G Schillaci & E Mannarino

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  1. G Ciuffetti
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  2. L Pasqualini
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  3. M Pirro
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  4. R Lombardini
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  5. M De Sio
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  6. G Schillaci
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  7. E Mannarino
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Correspondence to G Ciuffetti.

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Ciuffetti, G., Pasqualini, L., Pirro, M. et al. Blood rheology in men with essential hypertension and capillary rarefaction. J Hum Hypertens 16, 533–537 (2002). https://doi.org/10.1038/sj.jhh.1001454

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  • DOI: https://doi.org/10.1038/sj.jhh.1001454

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