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  • Protocol for Sub-Study of the ASCOT Trial
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Protocol for Sub-study of the ASCOT Trial

Haemorheological, endothelial and platelet function in subjects with hypertension: relationship to cardiovascular risk and influence of antihypertensive treatment

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References

  1. MacMahon S et alBlood pressure stroke and coronary heart disease: Part I, prolonged differences in blood pressure: prospective observational studies corrected for regression dilution bias Lancet 1990 335 765–774

    Article  CAS  PubMed  Google Scholar 

  2. Lip GYH, Li Saw Hee FL Does hypertension confer a hypercoagulable state? J Hypertens 1998 16 913–916

    Article  CAS  PubMed  Google Scholar 

  3. Letcher RL et alDirect relationship between blood pressure and blood viscosity in normal and hypertensive subjects. Role of fibrinogen concentration Am J Med 1981 70 1195–1202

    Article  CAS  PubMed  Google Scholar 

  4. Koenig W et alAssociation between plasma viscosity and blood pressure Am J Hypertens 1991 4 529–536

    Article  CAS  PubMed  Google Scholar 

  5. Sweetnam PM et alFibrinogen, viscosity and the 10-year incidence of ischaemic heart disease Eur Heart J 1996 17 1814

    Article  CAS  PubMed  Google Scholar 

  6. Koenig W et alPlasma viscosity and the risk of coronary heart disease Arterioscler Thomb Vasc Biol 1998 18 768–772

    Article  CAS  Google Scholar 

  7. Lip GYH, Beevers DG Abnormalities of rheology and coagulation in hypertension J Hum Hypertens 1994 8 693–702

    CAS  PubMed  Google Scholar 

  8. Folsom AR et alProspective study of hemostatic factors and incidence of coronary heart disease Circulation 1997 96 1102–1108

    Article  CAS  PubMed  Google Scholar 

  9. Stone M, Thorpe J Plasma fibrinogen-a major coronary risk factor J Roy Coll Gen Prac 1985 35 565–569

    CAS  Google Scholar 

  10. Blann AD, Taberner DA A reliable marker of endothelial cell dysfunction: does it exist? Br J Haematol 1995 90 244–248

    Article  CAS  PubMed  Google Scholar 

  11. Lip GYH, Blann AD Von Willebrand Factor:a marker of endothelial dysfunction in vascular disorders? Cardiovasc Res 1997 34 255–265

    Article  CAS  PubMed  Google Scholar 

  12. Blann AD, Naqvi T, Waite M, McCollum CN Von Willebrand Factor and endothelial damage in essential hypertension J Hum Hypertens 1993 7 107–111

    CAS  PubMed  Google Scholar 

  13. Blann AD, Waite MA Von Willebrand factor and soluble E-selectin in hypertension: influence of treatment and value in predicting the progression of atherosclerosis Cor Art Dis 1996 7 143–147

    Article  CAS  Google Scholar 

  14. Blann AD, Lip GYH, Islim IF, Beevers DG Evidence of platelet activation in hypertension J Hum Hypertens 1997 11 607–609

    Article  CAS  PubMed  Google Scholar 

  15. Verhaar MC et alProgressive vascular damage in hypertension is associated with increased levels of circulating P-selectin J Hypertens 1998 16 45–50

    Article  CAS  PubMed  Google Scholar 

  16. Blann AD, Miller JP, McCollum CN von Willebrand factor and soluble E-selectin as predictors of cardiovascular disease progression in hyperlipidaemia Atherosclerosis 1997 132 151–156

    Article  CAS  PubMed  Google Scholar 

  17. Mitropoulos KA, Miller GJ, Martin JC, Cooper RJ Dieteary fat induces changes in factor V coagulant activity thorough plasma stearic acid concentration Arterioscl Thromb 1994 14 214–212

    Article  CAS  PubMed  Google Scholar 

  18. Lip GYH, Beevers DG Abnormalities of rheology and coagulation in hypertension J Hum Hypertens 1994 8 693–702

    CAS  PubMed  Google Scholar 

  19. Lee AJ The role of rheology and haemostatic factors in hypertension J Hum Hypertens 1997 11 767–776

    Article  CAS  PubMed  Google Scholar 

  20. Islim IF, Beevers DG, Bareford D The effect of antihypertensive drugs on in vivo platelet activity inessential hypertension J Hypertens 1992 10 379–383

    Article  CAS  PubMed  Google Scholar 

  21. Lever AF et alMortality amongstpatients of theGlasgow Blood Pressure clinic was high in the 1970s and 80s but has fallen since Clin Exper Hypertens 1999 21 553–562

    Article  CAS  Google Scholar 

  22. Staessen JA et alRandomised double-blind comparison of placebo and active treatment for olderpatients with isolated systolic hypertension (SYST-EUR Trial) Lancet 1997 350 754–764

    Article  Google Scholar 

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Spencer, C., Beevers, D. & Lip, G. Haemorheological, endothelial and platelet function in subjects with hypertension: relationship to cardiovascular risk and influence of antihypertensive treatment. J Hum Hypertens 15 (Suppl 1), S39–S42 (2001). https://doi.org/10.1038/sj.jhh.1001085

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