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Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women

International Journal of Obesity volume 31, pages 996–1003 (2007)Cite this article

Abstract

Background:

Overweight individuals commonly demonstrate elevated levels of inflammatory and cell adhesion molecules. Elevated levels of inflammation and adhesion have been implicated in the pathogenesis of cardiovascular disease. Aerobic exercise has been shown to be effective in altering specific biomarkers of inflammation and cell adhesion; however, little is known regarding the effects of resistance training (RT) on these biomarkers. This study examined the effects of 1 year of moderate-intensity RT on biomarkers of inflammation and adhesion in healthy, overweight women.

Methods and Results:

Participants included 28 (12 control, 16 RT) overweight (body mass index⩾25 kg/m2) women, aged 25–44 years, studied before and after 1 year of RT. C-reactive protein (CRP), interleukin-6 (IL-6), adiponectin, intracellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin were measured by standard enzyme-linked immunosorbent assays. Body composition, blood pressure, fasting blood lipids, glucose and insulin also were assessed. There were no significant changes in blood pressure, fasting blood lipids, glucose or insulin levels in either group after 1 year. There was also no change in body mass or fat mass in either group; however, there was a significant increase in lean body mass (P<0.05) in the RT group. Both CRP (P<0.01) and adiponectin (P<0.01) demonstrated significant improvements in the RT group, with no change in IL-6. Conversely, there were no associated changes in the biomarkers of cell adhesion in either group.

Conclusions:

This study demonstrates that moderate-intensity RT significantly results in modest improvements of inflammatory markers without affecting cell adhesion molecules in overweight women.

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References

  1. ##National Task Force on the Prevention and Treatment of Obesity: overweight, obesity, and health risk. Arch Intern Med 2000; 160: 898–904.

  2. Lamarche B . Abdominal obesity and its metabolic complications: implications for the risk of ischaemic heart disease. Coronary Artery Dis 1998; 9: 473–481.

    Article  CAS  Google Scholar 

  3. Stunkard AJ . The current status of treatment for obesity in adults. Res Publ Assoc Res Nerv Ment Dis 1984; 62: 157–173.

    CAS  PubMed  Google Scholar 

  4. Reaven GM . Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 1993; 44: 121–131.

    Article  CAS  Google Scholar 

  5. Grundy SM . Primary prevention of coronary heart disease: integrating risk assessment with intervention. Circulation 1999; 100: 988–998.

    Article  CAS  Google Scholar 

  6. Leon AS, Norstrom J . Evidence of the role of physical activity and cardiorespiratory fitness in the prevention of coronary heart disease. Quest 1995; 47: 311–319.

    Article  Google Scholar 

  7. Thompson PD . Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease. Arterioscler Thromb Vasc Biol 2003; 23: 1319–1321.

    Article  CAS  Google Scholar 

  8. American College of Sports Medicine Position Stand. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. Med Sci Sports Exerc 1998; 30: 975–991.

  9. Kraemer WJ, Adams K, Cafarelli E, Dudley GA, Dooly C, Feigenbaum MS et al. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc 2002; 34: 364–380.

    Article  Google Scholar 

  10. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79–83.

    Article  CAS  Google Scholar 

  11. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB . Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999; 282: 2131–2135.

    Article  CAS  Google Scholar 

  12. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW . C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999; 19: 972–978.

    Article  CAS  Google Scholar 

  13. Escobar-Morreale HF, Villuendas G, Botella-Carretero JI, Sancho J, San Millan JL . Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women. Diabetologia 2003; 46: 625–633.

    Article  CAS  Google Scholar 

  14. Heinrich PC, Castell JV, Andus T . Interleukin-6 and the acute phase response. Biochem J 1990; 265: 621–636.

    Article  CAS  Google Scholar 

  15. Blake GJ, Ridker PM . Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med 2002; 252: 283–294.

    Article  CAS  Google Scholar 

  16. Ridker PM . Novel risk factors and markers for coronary disease. Adv Intern Med 2000; 45: 391–418.

    CAS  PubMed  Google Scholar 

  17. Dong ZM, Wagner DD . Leukocyte–endothelium adhesion molecules in atherosclerosis. J Lab Clin Med 1998; 132: 369–375.

    Article  CAS  Google Scholar 

  18. Pasceri V, Willerson JT, Yeh ET . Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000; 102: 2165–2168.

    Article  CAS  Google Scholar 

  19. Hwang SJ, Ballantyne CM, Sharrett AR, Smith LC, Davis CE, Gotto Jr AM et al. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk in Communities (ARIC) study. Circulation 1997; 96: 4219–4225.

    Article  CAS  Google Scholar 

  20. Guray U, Erbay AR, Guray Y, Yilmaz MB, Boyaci AA, Sasmaz H et al. Levels of soluble adhesion molecules in various clinical presentations of coronary atherosclerosis. Int J Cardiol 2004; 96: 235–240.

    Article  Google Scholar 

  21. Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001; 107: 1255–1262.

    Article  CAS  Google Scholar 

  22. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J-I et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79–83.

    Article  CAS  Google Scholar 

  23. Ouchi N, Kihara S, Funahashi T, Matsuzawa Y, Walsh K . Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol 2003; 14: 561–566.

    Article  CAS  Google Scholar 

  24. Flegal KM, Carroll MD, Ogden CL, Johnson CL . Prevalence and trends in obesity among US adults, 1999–2000. JAMA 2002; 288: 1723–1727.

    Article  Google Scholar 

  25. Rifai N, Buring JE, Lee IM, Manson JE, Ridker PM . Is C-reactive protein specific for vascular disease in women? Ann Intern Med 2002; 136: 529–533.

    Article  CAS  Google Scholar 

  26. Blum C, Muller B, Huber P, Kraenzlin M, Schindler C, De Geyter C . Low-grade inflammation and estimates of insulin resistance during the menstrual cycle in lean and overweight women. J Clin Endocrinol Metab 2005; 90: 3230–3235.

    Article  CAS  Google Scholar 

  27. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–419.

    Article  CAS  Google Scholar 

  28. Fleck SJ, Kraemer WJ . Designing Resistance Training Programs, 2nd edn. Human Kinetics: Champaogn, IL, 1997.

    Google Scholar 

  29. Ross R . Atherosclerosis – an inflammatory disease. N Engl J Med 1999; 340: 115–126.

    Article  CAS  Google Scholar 

  30. Bruunsgaard H, Galbo H, Halkjaer-Kristensen J, Johansen TL, MacLean DA, Pedersen BK . Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage. J Physiol 1997; 499 (Part 3): 833–841.

    Article  CAS  Google Scholar 

  31. Tisi PV, Shearman CP . Biochemical and inflammatory changes in the exercising claudicant. Vasc Med 1998; 3: 189–198.

    Article  CAS  Google Scholar 

  32. Mattusch F, Dufaux B, Heine O, Mertens I, Rost R . Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. Int J Sports Med 2000; 21: 21–24.

    Article  CAS  Google Scholar 

  33. Thomas SJ, Cooney TE, Thomas DJ . Comparison of exertional indices following moderate training in collegiate athletes. J Sports Med Phys Fitness 2000; 40: 156–161.

    CAS  PubMed  Google Scholar 

  34. Church TS, Barlow CE, Earnest CP, Kampert JB, Priest EL, Blair SN . Associations between cardiorespiratory fitness and C-reactive protein in men. Arterioscler Thromb Vasc Biol 2002; 22: 1869–1876.

    Article  CAS  Google Scholar 

  35. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB . Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 2003; 11: 1055–1064.

    Article  CAS  Google Scholar 

  36. Rothenbacher D, Hoffmeister A, Brenner H, Koenig W . Physical activity, coronary heart disease, and inflammatory response. Arch Intern Med 2003; 163: 1200–1205.

    Article  Google Scholar 

  37. Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA et al. Adiponectin is not altered with exercise training despite enhanced insulin action. Am J Physiol Endocrinol Metab 2002; 283: E861–E865.

    Article  CAS  Google Scholar 

  38. Marcell TJ, McAuley KA, Traustadottir T, Reaven PD . Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 2005; 54: 533–541.

    Article  CAS  Google Scholar 

  39. Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 2003; 289: 1799–1804.

    Article  CAS  Google Scholar 

  40. Brekke HK, Lenner RA, Taskinen MR, Mansson JE, Funahashi T, Matsuzawa Y et al. Lifestyle modification improves risk factors in type 2 diabetes relatives. Diabetes Res Clin Pract 2005; 68: 18–28.

    Article  Google Scholar 

  41. Jurimae J, Purge P, Jurimae T . Adiponectin is altered after maximal exercise in highly trained male rowers. Eur J Appl Physiol 2005; 93: 502–505.

    Article  Google Scholar 

  42. Kriketos AD, Gan SK, Poynten AM, Furler SM, Chisholm DJ, Campbell LV . Exercise increases adiponectin levels and insulin sensitivity in humans. Diabetes Care 2004; 27: 629–630.

    Article  Google Scholar 

  43. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000; 20: 1595–1599.

    Article  CAS  Google Scholar 

  44. Havel PJ . Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med (Maywood) 2001; 226: 963–977.

    Article  CAS  Google Scholar 

  45. Yang AL, Chen HI . Chronic exercise reduces adhesion molecules/iNOS expression and partially reverses vascular responsiveness in hypercholesterolemic rabbit aortae. Atherosclerosis 2003; 169: 11–17.

    Article  CAS  Google Scholar 

  46. Arosio E, Minuz P, Prior M, Zuliani V, Gaino S, De Marchi S et al. Vascular adhesion molecule-1 and markers of platelet function before and after a treatment with iloprost or a supervised physical exercise program in patients with peripheral arterial disease. Life Sci 2001; 69: 421–433.

    Article  CAS  Google Scholar 

  47. Wegge JK, Roberts CK, Ngo TH, Barnard RJ . Effect of diet and exercise intervention on inflammatory and adhesion molecules in postmenopausal women on hormone replacement therapy and at risk for coronary artery disease. Metabolism 2004; 53: 377–381.

    Article  CAS  Google Scholar 

  48. Adamopoulos S, Parissis J, Kroupis C, Georgiadis M, Karatzas D, Karavolias G et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 2001; 22: 791–797.

    Article  CAS  Google Scholar 

  49. Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 1999; 100: 2473–2476.

    Article  CAS  Google Scholar 

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Acknowledgements

This study was supported financially in part through grants from NIH Grant No. 5R01DK060743-03, American Heart Association Grant No. 0410034Z, and General Clinical Research Center Program, NCRR/NIH No. M01-RR00400.

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Authors and Affiliations

  1. Division of Cardiovascular Diseases, Mayo Clinic, University of Minnesota, Minneapolis, MN, USA

    T P Olson, D R Dengel, A S Leon & K H Schmitz

  2. Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA

    D R Dengel

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Correspondence to T P Olson.

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Olson, T., Dengel, D., Leon, A. et al. Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women. Int J Obes 31, 996–1003 (2007). https://doi.org/10.1038/sj.ijo.0803534

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