Abstract
Objective:
To examine the impact of childhood body mass index (BMI) on timing of puberty, adult stature and obesity.
Design:
A retrospective school-based cohort follow-up study.
Subjects:
A total of 1520 men born between 1927 and 1956 with serial height and weight measurements from the age of 9 to 18, followed up in adulthood at a mean age of 63 years.
Measurements:
Prepubertal (child) BMI; age at peak height velocity (APHV); adult leg length, waist and hip circumference (self-reported), and height and weight (measured).
Results:
Boys with a higher childhood BMI tended to have an earlier puberty (per s.d. increase in child BMI: −0.31 years, 95% confidence interval (CI): −0.23 to −0.39, P<0.001). Childhood BMI correlated strongly and positively with adult adiposity, as measured by BMI (1.24 kg/m2, 95% CI: 1.04–1.45, P<0.001), waist (1.94 cm, 95% CI: 1.50–2.37, P<0.001) and hip (1.91 cm, 95% CI: 1.55–2.28, P<0.001). It correlated inversely with leg length (−0.40 cm, 95% CI: −0.68 to −0.12, P=0.005), but not significantly with height or trunk length. Boys with a later puberty tended to be taller (per s.d. increase in APHV: 0.57 cm, 95% CI: 0.17–0.97, P=0.006) and less adipose as adults (−0.55 kg/m2, 95% CI: −0.33 to −0.77, P<0.001).
Conclusion:
The long-term consequences of childhood obesity into adulthood are well known, but the potential impact on early pubertal maturation is less well appreciated. The factors that contribute to the onset and persistence of childhood obesity require more public health focus.
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References
Livingstone MB . Childhood obesity in Europe: a growing concern. Public Health Nutr 2001; 4: 109–116.
Jebb SA, Rennie KL, Cole TJ . Prevalence of overweight and obesity among young people in Great Britain. Public Health Nutr 2004; 7: 461–465.
Serdula MK, Ivery D, Coates RJ, Freedman DS, Williamson DF, Byers T . Do obese children become obese adults?. A review of the literature. Prev Med 1993; 22: 167–177.
Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH . Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 1997; 337: 869–873.
Bray GA . Etiology and pathogenesis of obesity. Clin Cornerstone 1999; 2: 1–15.
Guo SS, Chumlea WC . Tracking of body mass index in children in relation to overweight in adulthood. Am J Clin Nutr 1999; 70: 145S–148S.
Law CM, Shiell AW, Newsome CA, Syddall HE, Shinebourne EA, Fayers PM et al. Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age. Circulation 2002; 105: 1088–1092.
Marti A, Marcos A, Martinez JA . Obesity and immune function relationships. Obesity Reviews 2001; 2: 131–140.
Wright CM, Parker L, Lamont D, Craft AW . Implications of childhood obesity for adult health: findings from thousand families cohort study. BMJ 2001; 323: 1280–1284.
Chu NF, Rimm EB, Wang DJ, Liou HS, Shieh SM . Clustering of cardiovascular disease risk factors among obese schoolchildren: the Taipei Children Heart Study. Am J Clin Nutr 1998; 67: 1141–1146.
Chen W, Srinivasan SR, Elkasabany A, Berenson GS . Cardiovascular risk factors clustering features of insulin resistance syndrome (Syndrome X) in a biracial (Black–White) population of children, adolescents, and young adults: the Bogalusa Heart Study. Am J Epidemiol 1999; 150: 667–674.
Grunberg H, Thetloff M . The cardiovascular risk factor profile of Estonian school children. Acta Paediatr 1998; 87: 37–42.
Reilly JJ, Methven E, McDowell ZC, Hacking B, Alexander D, Stewart L et al. Health consequences of obesity. Arch Dis Child 2003; 88: 748–752.
Eriksson J, Forsen T, Osmond C, Barker D . Obesity from cradle to grave. Int J Obes Relat Metab Disord 2003; 27: 722–727.
Dietz WH . Critical periods in childhood for the development of obesity. Am J Clin Nutr 1994; 59: 955–959.
Binkin NJ, Yip R, Fleshood L, Trowbridge FL . Birth weight and childhood growth. Pediatrics 1988; 82: 828–834.
Parsons TJ, Power C, Manor O . Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study. BMJ 2001; 323: 1331–1335.
Moss AR . Epidemiology and the politics of needle exchange. Am J Public Health 2000; 90: 1385–1387.
Williams S, Dickson N . Early growth, menarche, and adiposity rebound. Lancet 2002; 359: 580–581.
Skinner JD, Bounds W, Carruth BR, Morris M, Ziegler P . Predictors of children's body mass index: a longitudinal study of diet and growth in children aged 2–8 y. Int J Obes Relat Metab Disord 2004; 28: 476–482.
Dietz WH . Overweight in childhood and adolescence. N Engl J Med 2004; 350: 855–857.
Cole TJ . Children grow and horses race: is the adiposity rebound a critical period for later obesity? BMC Pediatr 2004; 4: 6.
Guo SS, Wu W, Chumlea WC, Roche AF . Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence. Am J Clin Nutr 2002; 76: 653–658.
Lusky A, Barell V, Lubin F, Kaplan G, Layani V, Shohat Z et al. Relationship between morbidity and extreme values of body mass index in adolescents. Int J Epidemiol 1996; 25: 829–834.
Roemmich JN, Rogol AD . Hormonal changes during puberty and their relationship to fat distribution. Am J Hum Biol 1999; 11: 209–224.
Shalitin S, Phillip M . Role of obesity and leptin in the pubertal process and pubertal growth – a review. Int J Obes Relat Metab Disord 2003; 27: 869–874.
Luo ZC, Karlberg J . Critical growth phases for adult shortness. Am J Epidemiol 2000; 152: 125–131.
He Q, Karlberg J . BMI in childhood and its association with height gain, timing of puberty, and final height. Pediatr Res 2001; 49: 244–251.
Cheng LZ, Bun CY, He Q, Albertsson-Wikland K, Karlberg J . Growth in early life and its relation to pubertal growth. Epidemiology 2003; 14: 65–73.
Rogol AD, Roemmich JN, Clark PA . Growth at puberty. J Adolesc Health 2002; 31 (Suppl): 192–200.
van Lenthe FJ, Kemper CG, van Mechelen W . Rapid maturation in adolescence results in greater obesity in adulthood: the Amsterdam Growth and Health Study. Am J Clin Nutr 1996; 64: 18–24.
Okasha M, McCarron P, McEwen J, Davey Smith G . Age at menarche: secular trends and association with adult anthropometric measures. Ann Hum Biol 2001; 28: 68–78.
Apter D, Reinila M, Vihko R . Some endocrine characteristics of early menarche, a risk factor for breast cancer, are preserved into adulthood. Int J Cancer 1989; 44: 783–787.
Forman D, Pike MC, Davey G, Dawson S, Baker K, Chilvers CED et al. Aetiology of testicular cancer:association with congenital abnormalities, age at puberty, infertility, and exercise. BMJ 1994; 308: 1393–1399.
Berkey CS, Frazier AL, Gardner JD, Colditz GA . Adolescence and breast carcinoma risk. Cancer 1999; 85: 2400–2409.
Diamandis EP, Yu H . Does prostate cancer start at puberty? J Clin Lab Anal 1996; 10: 468–469.
Giles GG, Severi G, English DR, McCredie MR, MacInnis R, Boyle P et al. Early growth, adult body size and prostate cancer risk. Int J Cancer 2003; 103: 241–245.
Friend GE . The Diet of School Children. J State Med 1933; XLII: 1–8.
Friend GE . Diet in relation to physical efficiency. BMJ 1936; 2: 276–281.
Friend GE . The Place of vegetables and fresh fruit in the well-balanced diet. J R Hortic Soc 1937; 62: 286–295.
Friend GE . The Schoolboy A Study of his Nutrition, Physical Development and Health. W. Heffer & Sons Ltd: Cambridge, 1935.
Rosenbaum S . 100 years of heights and weights. J R Statist Soc A 1988; 151: 276–309.
Armstrong HE . The Schoolboy – A Study of Health in Christ's Hospital. Wine and Food 1935; 4: 2–11.
Royston P . Choice of scale for cubic smoothing spline models in medical applications. Stat Med 2000; 19: 1191–1205.
Riedel KS, Imre K . Smoothing spline growth curves with covariates. Commun Statist Theory Meth 1993; 22: 1795–1818.
Hagg U, Taranger J . Height and height velocity in early, average and late maturers followed to the age of 25: a prospective longitudinal study of Swedish urban children from birth to adulthood. Ann Hum Biol 1991; 18: 47–56.
Kemper HC, Storm-van Essen L, Verschuur R . Height velocity in a group of teenage boys. Ann Hum Biol 1985; 12: 545–549.
Iuliano-Burns S, Mirwald RL, Bailey DA . Timing and magnitude of peak height velocity and peak tissue velocities for early, average, and late maturing boys and girls. Am J Hum Biol 2001; 13: 1–8.
Stata Statistical Software 7.0. Stata Corporation: College Station, TX, USA; 2001.
Tanner JM, Whitehouse RH, Takaishi M . Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. I. Arch Dis Child 1966; 41: 454–471.
Tanner JM, Whitehouse RH, Takaishi M . Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II. Arch Dis Child 1966; 41: 613–635.
Karlberg J . Secular trends in pubertal development. Horm Res 2002; 57 (Suppl 2): 19–30.
Ong KK, Ahmed ML, Dunger DB . The role of leptin in human growth and puberty. Acta Paediatr Suppl 1999; 88: 95–98.
Weise M, Eisenhofer G, Merke DP . Pubertal and gender-related changes in the sympathoadrenal system in healthy children. J Clin Endocrinol Metab 2002; 87: 5038–5043.
Cancello R, Tounian A, Poitou C, Clement K . Adiposity signals, genetic and body weight regulation in humans. Diabetes Metab 2004; 30: 215–227.
Tomlinson JW, Stewart PM . The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue. Horm Metab Res 2002; 34: 746–751.
Belanger C, Luu-The V, Dupont P, Tchernof A . Adipose tissue intracrinology: potential importance of local androgen/estrogen metabolism in the regulation of adiposity. Horm Metab Res 2002; 34: 737–745.
Hindmarsh P, Smith PJ, Brook CG, Matthews DR . The relationship between height velocity and growth hormone secretion in short prepubertal children. Clin Endocrinol (Oxf) 1987; 27: 581–591.
Zhang J, Peddada SD, Malina RM, Rogol AD . Longitudinal assessment of hormonal and physical alterations during normal puberty in boys. VI. Modeling of growth velocity, mean growth hormone (GH mean), and serum testosterone (T) concentrations. Am J Hum Biol 2000; 12: 814–824.
Tanner JM . Growth at Adolescence, 2nd edn. Blackwell Scientific Publications: Oxford, 1962.
Yarnell JW, Limb ES, Layzell JM, Baker IA . Height: a risk marker for ischaemic heart disease: prospective results from the Caerphilly and Speedwell Heart Disease Studies. Eur Heart J 1992; 13: 1602–1605.
Wannamethee SG, Shaper AG, Whincup PH, Walker M . Adult height, stroke, and coronary heart disease. Am J Epidemiol 1998; 148: 1069–1076.
Gunnell D, Okasha M, Davey Smith G, Oliver SE, Sandhu J, Holly JMP . Height, leg length, and cancer risk: a systematic review. Epidemiol Rev 2001; 23: 296–325.
Lawlor DA, Ebrahim S, Davey Smith G . The association between components of adult height and Type II diabetes and insulin resistance: British Women's Heart and Health Study. Diabetologia 2002; 45: 1097–1106.
Davey Smith G, Greenwood R, Gunnell D, Sweetnam P, Yarnell J, Elwood P . Leg length, insulin resistance, and coronary heart disease risk: the Caerphilly Study. J Epidemiol Commun Health 2001; 55: 867–872.
Beunen G, Malina RM, Lefevre J, Claessens AL, Renson R, Simons J et al. Size, fatness and relative fat distribution of males of contrasting maturity status during adolescence and as adults. Int J Obes Relat Metab Disord 1994; 18: 670–678.
Inelmen EM, Sergi G, Coin A, Miotto F, Peruzza S, Enzi G . Can obesity be a risk factor in elderly people? Obes Rev 2003; 4: 147–155.
Zemel BS, Katz SH . The contribution of adrenal and gonadal androgens to the growth in height of adolescent males. Am J Phys Anthropol 1986; 71: 459–466.
Rogol AD . Growth at puberty: interaction of androgens and growth hormone. Med Sci Sports Exerc 1994; 26: 767–770.
Siervogel RM, Demerath EW, Schubert C, Remsberg KE, Chumlea WC, Sun S et al. Puberty and body composition. Horm Res 2003; 60 (Suppl 1): 36–45.
Ebbeling CB, Pawlak DB, Ludwig DS . Childhood obesity: public-health crisis, common sense cure. Lancet 2002; 360: 473–482.
Lobstein T, Baur L, Uauy R . Obesity in children and young people: a crisis in public health. Obes Rev 2004; 5 (Suppl 1): 4–85.
Acknowledgements
We gratefully acknowledge the financial support of the University of Bristol, Cancer Research UK and the Medical Research Council for different elements of the cohort follow-up, Rosemary Currer and Caroline King for research secretarial support to the study, and Pete Shiarly for his development of the study database. In particular, we thank Christ's Hospital for permitting access to this unique resource and all Old Blues that participated.
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Sandhu, J., Ben-Shlomo, Y., Cole, T. et al. The impact of childhood body mass index on timing of puberty, adult stature and obesity: a follow-up study based on adolescent anthropometry recorded at Christ's Hospital (1936–1964). Int J Obes 30, 14–22 (2006). https://doi.org/10.1038/sj.ijo.0803156
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DOI: https://doi.org/10.1038/sj.ijo.0803156
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