Abstract
OBJECTIVE:
To investigate the relationship between resting metabolic rate (RMR) and subsequent changes in body size and degree of fatness in a group of adult Caucasian Italians.
DESIGN:
Prospective, longitudinal, observational study.
SUBJECTS:
In total, 155 subjects (72 males and 83 females, age range: 18–55 y; BMI: 17.5–63.4 kg/m2) were evaluated. In total, 43 (26 m and 17 f; BMI: 28.9±1.1 kg/m2, mean±s.e.m.) of them were reassessed 10–12 y later.
MEASUREMENTS:
Anthropometric and body composition (bioimpedance analysis) parameters and RMR (indirect calorimetry) were taken at baseline and after 10–12 y.
RESULTS:
Subjects (15 m, 8 f) who gained body weight (arbitrarily defined as a change in body weight ≥5 kg) had baseline BMI (29.9±1.8 vs 28.0±1.4; P=NS) and body composition in terms of fat mass (FM%) and fat-free mass (FFM kg) comparable to those of the subjects (11 m, 9 f) whose body weight remained stable. Baseline RMR was significantly lower in subjects who gained weight than in those who did not (108±2.1 vs 122±3.1 kJ/kg-FFM 24 h; P<0.001), although it did not differ significantly between the two groups (119±2 vs 121±2 kJ/kg-FFM 24 h; P=NS) 10–12 y later. Baseline RMR was inversely correlated to both change in body weight (r=−0.57; P<0.001) and FM (r=−0.50; P<0.001).
CONCLUSION:
A low RMR normalized for FFM appears to be associated with body weight gain in the long run in adult Caucasian Italians.
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References
Ravussin E, Burnand B, Schutz Y, Jequier E . Twenty-four hour energy expenditure and resting metabolic rate in obese, moderately obese and control subjects. Am J Clin Nutr 1982; 35: 566–573.
Verga S, Buscemi S, Caimi G . Resting energy expenditure and body composition in morbidly obese, obese and control subjects. Acta Diabetol 1994; 31: 47–51.
Ravussin E, Lillioja S, Knowler WC, Christin L, Freymond D, Abbott WGH, Boyce V, Howard BV, Bogardus C . Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med 1988; 318: 467–472.
Roberts SB, Savage J, Coward WA, Chew B, Lucas A . Energy expenditure and intake in infants born to lean and overweight mothers. N Engl J Med 1988; 318: 461–466.
Griffiths M, Payne PR, Stunkard AJ, Rivers JP, Coc M . Metabolic rate and physical development in children at risk of obesity. Lancet 1990; 336: 76–78.
Seidell JC, Muller DC, Sorkin JD, Andres R . Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on aging. Int J Obesity Relat Metab Disord 1992; 16: 667–674.
Katzmarzyk PT, Perusse L, Tremblay A, Bouchard C . No association between resting metabolic rate or respiratory exchange ratio and subsequent changes in body mass and fatness: 5.5 year follow-up of the Québec family study. Eur J Clin Nutr 2000; 54: 610–614.
Weinsier RL, Nelson KM, Hensrud DD, Darnell BE, Hunter GR, Schutz Y . Metabolic predictors of obesity. Contribution of energy expenditure, thermic effect of food, and fuel utilization to four year weight gain of post-obese and never-obese women. J Clin Invest 1995; 95: 980–985.
Khaled MA, McCutcheon MJ, Reddy S, Pearman PL, Hunter GR, Weinsier RL . Electrical impedance in assessing human body composition. J Appl Physiol 1986; 60: 1327–1332.
Jéquier E, Acheson K, Schutz Y . Assessment of energy expenditure and fuel utilization in man. Ann Rev Nutr 1987; 7: 187–208.
Ravussin E, Bogardus C . Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization. Am J Clin Nutr 1989; 49: 968–975.
Rossner S . Defining success in obesity management. Int J Obes Relat Metab Disord 1997; 21s1: S2–S4.
Weigle DS, Kuijper JL . Obesity genes and the regulation of body fat content. Bioessays 1996; 18: 867–874.
Jequiér E, Tappy L . Regulation of body weight in humans. Physiol Rev 1999; 79: 451–480.
York D, Bouchard C . How obesity develops: insights from the new biology. Endocrine 2000; 13: 143–154.
Kimm SY, Glynn NW, Aston CE, Damcott CM, Poehlman ET, Daniels SR, Ferrell RE . Racial differences in the relation between uncoupling protein genes and resting energy expenditure. Am J Clin Nutr 2002; 75: 714–719.
Arner P, Hoffstedt J . Adrenoceptor genes in human obesity. J Intern Med 1999; 245: 667–672.
Clement K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD . Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 1995; 333: 382–383.
Vaughan L, Zurlo F, Ravussin E . Aging and energy expenditure. Am J Clin Nutr 1991; 53: 821–825.
Hogdon JA, Fitzgerald PI . Validity of impedance prediction at various levels of fatness. Hum Biol 1987; 59: 281–298.
Byrne NM, Weinsier RL, Hunter GR, Desmond R, Patterson MA, Darnell BE, Zuckerman PA . Influence of distribution of lean body mass on resting metabolic rate after weight loss and weight regain: comparison of responses in white and black women. Am J Clin Nutr 2003; 77: 1368–1373.
Zurlo F, Lillioja S, Del Puente A, Nyomba BL, Raz I, Saad MF, Swinburn BA, Knowler WC, Bogardus C, Ravussin E . Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24 h RQ. Am J Physiol 1990; 259: E650–E657.
Swinburn B, Ravussin E . Energy balance or fat balance. Am J Clin Nutr 1993; 57: 766s–771s.
Acknowledgements
We express their gratitude to professor Yves Schutz, University of Lausanne (CH) for his critical comments during the revision of this manuscript and to Nancy W Birch, BA who edited the English. This study was supported in part by the Italian Ministry of Education (MURST funds 60% project 2001).
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Buscemi, S., Verga, S., Caimi, G. et al. Low relative resting metabolic rate and body weight gain in adult Caucasian Italians. Int J Obes 29, 287–291 (2005). https://doi.org/10.1038/sj.ijo.0802888
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DOI: https://doi.org/10.1038/sj.ijo.0802888
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