Abstract
OBJECTIVE: To analyze the effects of the mutations in the β3-adrenoceptor (β3-AR) gene and/or uncoupling protein3 (UCP3) gene promoter on body fat distribution and glycemic control after mild weight reduction in overweight-obese subjects with coronary artery disease (CAD) or metabolic syndrome.
DESIGN: Clinical intervention study of the −300 kcal/day mild weight reduction program for 12 weeks.
SUBJECTS: A total of 224 overweight-obese subjects with CAD or metabolic disorder, subdivided into the following four categories: (1) wild type (TT-CC, n=73); (2) only UCP3 promoter variant (TT-CT/TT, n=90); (3) only β3-AR variant (TA/AA-CC, n=29); (4) both variants (TA/AA-CT/TT, n=32).
MEASUREMENT: Body mass index (BMI), blood pressure, calorie intakes, body fat distribution, serum glucose, insulin, free fatty acids, C-peptide and lipids before and after weight reduction.
RESULTS: After 12 weeks, all subjects lost approximately 5% of their initial body weight. Despite similar weight reduction, the highest decreases in abdominal adipose tissue at both L1 and L4 levels were observed in the ‘wild-type’ group (P<0.001) and the second highest in ‘only UPC3 promoter variant’ group (P<0.001). On the other hand, both variant-carriers had the smallest reduction only in visceral fat area at the L4 level. All subjects except both variant-carriers showed significant reductions in the fasting levels of glucose and FFA. The response areas of glucose (P<0.01) and insulin (P<0.05) were reduced largest in the ‘wild-type’ group and second largest in the ‘UCP3 promoter variant’ group.
CONCLUSION: All the four groups showed similar weight reduction after −300 kcal/d for 12 weeks. However, the beneficial effects on body fat distribution and glycemic control were greatest in the ‘wild-type’ group and smallest in ‘both variants’ group. In addition, these effects were less beneficial in carriers with β3-AR gene variant than with UCP3 gene promoter variant.
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This study was partly supported by the Ministry of Healthy and Welfare, Korea (Project number: HMG-00-GN-01-0001), and the Brain Korea 21 project for Medical Science and for Antioxidant Nutrition Research.
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Kim, O., Cho, E., Park, H. et al. Additive effect of the mutations in the β3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome. Int J Obes 28, 434–441 (2004). https://doi.org/10.1038/sj.ijo.0802562
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DOI: https://doi.org/10.1038/sj.ijo.0802562
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