Abstract
OBJECTIVE: The autonomic nervous system (ANS) is a key factor in the regulation of energy balance and body fat storage;however, to what extent the physical activity during the childhood years contributes to variations in ANS function is still unclear. The present study was designed to investigate the ANS activity in lean and obese children, focusing on the differences in physical activity levels.
SUBJECTS: This study was performed on 1080 school children initially recruited to the present study. In all, 24 physically active and 24 inactive obese children (≥120% of the standard body weight) were chosen as samples. Then, 24 lean-active and 24 lean-inactive children, who were matched individually in age, gender, height, and the amount of sports activity, were carefully selected from the remaining children.
MEASUREMENTS: Physical activity was classified as the frequency of participation in after-school sports activities (active; ≥3 times per week, inactive; nothing). The ANS activities were measured during the resting condition by means of heart rate (HR) variability power spectral analysis, which enables us to identify separate frequency components, that is, low frequency (LF; 0.03–0.15 Hz), reflecting mixed sympathetic (SNS) and parasympathetic nervous system (PNS) activity, high frequency (HF; 0.15–0.5 Hz), mainly associated with PNS activity, and total power (TP; 0.03–0.5 Hz), evaluating the overall ANS activity. The spectral powers were log transformed for statistical testing.
RESULTS: The lean-active group demonstrated lower resting HR as well as significantly higher TP, LF, and HF powers compared to the remaining groups. In contrast, the obese-inactive group showed significantly lower TP (P<0.05 vs the remaining groups), LF (P<0.05 vs the lean groups), and HF power (P<0.05 vs the lean groups), respectively. The obese-active and lean-inactive groups were nearly identical in all spectral parameters. The correlation analysis revealed that TP among 48 inactive children was significantly and negatively associated with the percentage of body fat (r=−0.53, P<0.001); however, such correlation among 48 active children was modest (r=−0.33, P=0.02).
CONCLUSION: Our data suggest that obese children possess reduced sympathetic as well as parasympathetic nervous activities as compared to lean children who have similar physical activity levels. Such autonomic reduction, associated with the amount of body fat in inactive state, might be an etiological factor of onset or development of childhood obesity. On the other hand, regular physical activities could contribute to enhance the overall ANS activity in both lean and obese children. These findings further imply that regular physical activity might be effective in preventing and treating obesity beginning in the childhood.
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References
World Health Organization. Obesity: preventing and managing the global epidemic, World H ealth O rganization Technical Report Series No. 894. World Health Organization: Geneva, Switzerland; 2000.
Nagai N, Senga S . Trends in obesity among preschool and school children in administrative district of Hyogo Prefecture (Japan) 1981–2000. Jpn J Nutr Diet, 2003; 61: 189–194.
Japanese Society of School Health. The Student Health Survey in Japan, 1998. pp 189–205.
Anderson RE, Crespo CJ, Bartlett SJ, Cheskin LJ, Pratt M . Relationship of physical activity and television watching with body weight and level of fatness among children. JAMA, 1988; 279: 938–942.
Goran MI . Metabolic precursors and effects of obesity in children: a decade of progress, 1990–1999. Am J Clin Nutr, 2001; 73: 158–171.
Bray GA . Autonomic and endocrine factors in the regulation of energy balance. Fed Proc, 1986; 45: 1404–1410.
Acheson KJ, Ravussin E, Schoeller DA, Christin L, Bourquin L, Baertschi P, Danforth Jr E, Jequier E . Two-week stimulation or blockade of the sympathetic nervous system in man: influence on body weight, body composition, and twenty-four-hour energy expenditure. Metabolism, 1988; 37: 91–98.
Buemann B, Astrup A, Madsen J, Christensen NJ . A 24-h energy expenditure study on reduced-obese and nonobese women: effect of beta-blockade. Am J Clin Nutr, 1992; 56: 662–670.
Toubro S, Sorensen TIA, Ronn B, Christensen NJ, Astrup A . Twenty-four-hour energy expenditure: the role of body composition, thyroid status, sympathetic activity, and family membership. J Clin Endocrinol Metab, 1996; 81: 2670–2674.
Matsumoto T, Miyawaki T, Ue H, Zenji C, Moritani T . Autonomic responsiveness to acute cold exposure in obese and non-obese young women. Int J Obes Relat Metab Disord, 1999; 23: 793–800.
Matsumoto T, Miyawaki T, Ue H, Yuasa T, Miyatsuji A, Moritani T . Effects of capsaicin-containing yellow curry sauce on sympathetic nervous system activity and diet-induced thermogenesis in lean and obese young women. J Nutr Sci Vitaminol, 2000; 46: 309–315.
Matsumoto T, Miyawaki C, Ue T, Kanda T, Yoshitake Y, Moritani T . Comparison of thermogenetic sympathetic response to food intake between obese and non-obese young women. Obes Res, 2001; 9: 78–85.
Peterson HR, Rothschild M, Weinberg CR, Fell RD, McLeish KR, Pfeifer MA . Body fat and the activity of the autonomic nervous system. N Engl J Med, 1988; 318: 1077–1083.
Petretta M, Bonaduce D, de Filippo E, Mureddu GF, Scalfi L, Marciano F, Bianchi V, Salemme L, de Simone G, Contaldo F . Assessment of cardiac autonomic control by heart period variability in patients with early onset familial obesity. Eur J Clin Invest, 1995; 25: 826–832.
Nagai N, Matsumoto T, Kita H, Moritani T . Autonomic nervous system activity and the state and development of obesity in Japanese school children. Obes Res, 2003; 11: 25–32.
Davy KP, DeSouza CA, Jones PP, Seals DR . Elevated heart rate variability in physically active young and older adult women. Clin Sci, 1998; 94: 579–584.
Davy KP, Miniclier NL, Taylor JA, Stevenson ET, Seals DR . Elevated heart rate variability in physically active postmenopausal women: a cardioprotective effect? Am J Physiol, 1996; 271 (Heart Circ. Physiol. 40): H455–H460.
Goldsmith RG, Bigger JT, Steinman RC, Fleiss JL . Comparison of 24-h parasympathetic activity in endurance trained and untrained young men. J Am Coll Cardiol, 1992; 20: 552–558.
Amano M, Kanda T, Ue H, Moritani T . Effects of exercise training on autonomic nervous system in obese middle aged individuals. Med Sci Sport Exer, 2001; 33: 1287–1291.
Gutin B, Owens S, Slavens G, Riggs S, Treiber F . Effect of physical training on heart-period variability in obese children. J Pediatr, 1997; 130: 938–943.
Resources Council, Ministry of Education, Culture, Sports, Science and Technology of Japan. The Japanese Food Consumption Table. (5 th revision) Printing Bureau of Finance Ministry: Tokyo; 2001. pp 30–303.
Tyrrell VJ, Richards G, Hofman P, Gillies GF, Robinson E, Cutfield WS . Foot-to-foot bioelectrical impedance analysis: a valuable tool for the measurement of body composition in children. Int J Obes Relat Metab Disord, 2001; 25: 273–278.
Kotani K, Nishida M, Yamashita S, Funahashi T, Fujioka S, Tokunaga K, Ishikawa K, Tarui S, Matsuzawa Y . Two decades of annual medical examinations in Japanese obese children: do obese children grow into obese adults? Int J Obes Relat Metab Disord, 1997; 21: 912–921.
Gutin B, Owens S . Role of exercise intervention in improving body fat distribution and risk profile in children. Am J Human Biol, 1999; 11: 237–247.
Moritani T, Hayashi T, Shinohara M, Mimasa F, Shibata M . Comparison of sympatho-vagal function among diabetic patients, normal controls and endurance athletes by heart rate spectral analysis. J Sport Med Sci, 1993; 7: 31–39.
Moritani T, Hayashi T, Shinohara M, Mimasa F, Masuda I, Nakao K . Sympatho-vagal activities of NIDDM patients during exercise as determined by heart rate spectral analysis. In: Kawamori R, Vranic M, Horton ES, Kubota M (eds). Glucose fluxes, exercise and diabetes. Smith-Gordon: Great Britain; 1995. pp 91–96.
Hayashi T, Masuda I, Shinohara M, Moritani T, Nakao K . Autonomic nerve activity during physical exercise and postural change: investigations by power spectral analysis of heart rate variability. Jpn J Biochem Exerc, 1994; 6: 30–37.
Malina RM, Bouchard C . Heart, blood, and lung changes during growth. In: Growth, maturation, and physical activity. Human Kinetics Books: Champaign, IL; 1991. pp 163–164.
Rompelman O, Coenen AJR, Kitney RI . Measurement of heart-rate variability: part 1—comparative study of heart rate variability analysis methods. Med Biol Eng Comput, 1977; 15: 233–239.
Task force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standard of measurements, physiological interpretation and clinical use. Circulation, 1996; 93: 1043–1065.
Akselrod S, Gordon D, Ubel FA, Shannon DC, Barger AC, Cohen RJ . Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science, 1981; 213: 220–222.
Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell'Orto S, Piccaluga E, Turiel M, Baselli G, Cerutti S, Malliani A . Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res, 1986; 59: 178–193.
Nonogaki K . New insight into sympathetic regulation of glucose and fat metabolism. Diabetologia, 2000; 43: 533–549.
Akinci A, Celiker A, Baykal E, Tezic T . Heart rate variability in diabetic children: sensitivity of the time- and frequency-domain methods. Pediatr Cardiol, 1993; 14: 140–146.
Rollins MD, Jenkins JG, Carson DJ, McClure BG, Mitchell RH, Imam SZ . Power spectral analysis of the electrocardiogram in diabetic children. Diabetologia, 1992; 35: 452–455.
Javarka K, Buchanew, Javorkova J, Zibolen M, Minarik M . Heart rate and its variability in juvenile hypertonics during respiratory maneuvers. Cilin Exp Hyperterns, 1998; 10: 391–409.
Acknowledgements
We are grateful to the children of the Misaki and Ikaruga elementary schools and their families for their participation during the experiments. We also wish to express our appreciation to the teachers in the Misaki and Ikaruga elementary schools for their kind support and great efforts. This study was supported in part by the Japanese Ministry of Education, Science, Sports, and Culture Grant-in-Aid for Scientific Research (B) 11480011.
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Nagai, N., Moritani, T. Effect of physical activity on autonomic nervous system function in lean and obese children. Int J Obes 28, 27–33 (2004). https://doi.org/10.1038/sj.ijo.0802470
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