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Association between weight fluctuation and fasting insulin concentration in Japanese men

International Journal of Obesity volume 27, pages 478–483 (2003)Cite this article

Abstract

OBJECTIVE: To investigate whether long-term weight fluctuation is associated with the fasting serum insulin concentration.

DESIGN AND SUBJECTS: Weight histories of 1932 male Japanese workers aged 40–59 y were analyzed in relation to their current fasting serum insulin concentration. MEASUREMENTS:Individual weight fluctuation was calculated by root mean square error (RMSE) along the linear regression line of weight measured at five to six different ages.

RESULTS: The mean RMSE and fasting insulin concentration were 1.22 kg and 4.5 μU/ml, respectively. The multivariate adjusted insulin level became higher with the increase in weight fluctuation. Subanalysis stratified by current body mass index (BMI) showed that the multivariate adjusted insulin level in individuals in the top quartile of fluctuation was 4.3 μU/ml, against 3.9 μU/ml in those in the bottom quartile (P=0.018, analysis of covariance (ANCOVA)) in the normal weight subgroup with current BMI below 25 kg/m2. In the overweight subgroup with BMI 25 kg/m2 or above, the level was 6.9 μU/ml in individuals in the top quartile and 6.2 μU/ml in those in the bottom quartile (P=0.054, ANCOVA).

CONCLUSION: The results suggest that weight fluctuation increases the risk of developing hyperinsulinemia. Prospective observations together with measurement of changes in adiposity are needed for confirmation.

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References

  1. Haffner SM . Epidemiology of insulin resistance and its relation to coronary artery disease. Am J Cardiol 1999; 84: 11S–14S.

    Article  Google Scholar 

  2. Facchini FS, Hua N, Abbasi F, Reaven GM . Insulin resistance as a predictor of age-related diseases. J Clin Endocrinol Metab 2001; 86: 3574–3578.

    Article  CAS  Google Scholar 

  3. Després JP, Lamarche B, Mauriége P, Cantin B, Dagenais GR, Moorjani S, Lupien PJ . Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996; 334: 952–958.

    Article  Google Scholar 

  4. Burchfiel CM, Sharp DS, Curb JD, Rodriguez BL, Abbott RD, Arakaki R, Yano K . Hyperinsulinemia and cardiovascular disease in elderly men: The Honolulu heart program. Arterioscler Thromb Vasc Biol 1998; 18: 450–457.

    Article  CAS  Google Scholar 

  5. Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G . Insulin resistance and hypersecretion in obesity. J Clin Invest 1997; 100: 1166–1173.

    Article  CAS  Google Scholar 

  6. Doucet E, St-Pierre S, Almeras N, Mauriege P, Despres JP, Richard D, Bouchard C, Tremblay A . Fasting insulin levels influence plasma leptin levels independently from the contribution of adiposity: evidence from both a cross-sectional and an intervention study. J Clin Endocrinol Metab 2000; 85: 4231–4237.

    CAS  Google Scholar 

  7. Carlsson S, Persson PG, Alvarsson M, Efendic S, Norman A, Svanstrom L, Ostenson CG, Grill V . Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men. Am J Epidemiol 1998; 148: 539–545.

    Article  CAS  Google Scholar 

  8. Kahn BB, Flier JS . Obesity and insulin resistance. J Clin Invest 2000; 106: 473–481.

    Article  CAS  Google Scholar 

  9. Hanson RL, Narayan KM, McCance DR, Pettitt DJ, Jacobsson LT, Bennett PH, Knowler WC . Rate of weight gain, weight fluctuation, and incidence of NIDDM. Diabetes 1995; 44: 261–266.

    Article  CAS  Google Scholar 

  10. WHO. Defining the problem of overweight and obesity. In: Obesity: preventing and managing the global epidemic. Report of a WHO Consultation on Obesity. (Technical Report Series, No. 894). World Health Organization: Geneva; 1998. pp 7–14.

  11. Health promotion and nutrition division, Health service bureau, Ministry of Health and Welfare Japan. National Nutrition Survey in 1997 (in Japanese). Daiichi Shuppan Co: Tokyo; 1999.

  12. National Task Force on the Prevention and Treatment of Obesity. Weight cycling. J Am Med Assoc 1994; 272: 1196–1202.

  13. Muls E, Kempen K, Vansant G, Saris W . Is weight cycling detrimental to health? A review of the literature in humans. Int J Obes Relat Metab Disord 1995; 19: 46S–50S.

    Google Scholar 

  14. Lissner L, Brownell KD . Weight cycling, mortality, and cardiovascular disease: a review of epidemiological findings. In: Björntorp P, Brodoff BN (eds). Obesity. Lippincott Company: Philadelphia; 1992. pp 653–661.

    Google Scholar 

  15. Gunnell D, Berney L, Holland P, Maynard M, Blane D, Frankel S, Smith GD . How accurately are height, weight and leg length reported by the elderly, and how closely are they related to measurements recorded in childhood? Int J Epidemiol 2000; 29: 456–464.

    Article  CAS  Google Scholar 

  16. Stevens J, Keil JE, Waid LR, Gazes PC . Accuracy of current, 4-year, and 28-year self-reported body weight in an elderly population. Am J Epidemiol 1990; 132: 1156–1163.

    Article  CAS  Google Scholar 

  17. Lissner L, Andres R, Muller DC, Shimokata H . Body weight variability in men: metabolic rate, health and longevity. Int J Obes Relat Metab Disord 1990; 14: 373–383.

    CAS  Google Scholar 

  18. French SA, Jeffery RW, Folsom AR, Williamson DF, Byers T . Weight variability in a population-based sample of older women: reliability and intercorrelation of measures. Int J Obes Relat Metab Disord 1995; 19: 22–29.

    CAS  PubMed  Google Scholar 

  19. French SA, Jeffery RW, Folsom AR, Williamson DF, Byers T . Relation of weight variability and intentionality of weight loss to disease history and health-related variables in a population-based sample of women aged 55–59 years. Am J Epidemiol 1995; 142: 1306–1314.

    Article  CAS  Google Scholar 

  20. Morris RD, Rimm AA . Long-term weight fluctuation and non-insulin-dependent diabetes mellitus in white women. Ann Epidemiol 1992; 2: 657–664.

    Article  CAS  Google Scholar 

  21. Hanson RL, Jacobsson LT, McCance DR, Narayan KM, Pettitt DJ, Bennett PH, Knowler WC . Weight fluctuation, mortality and vascular disease in Pima Indians. Int J Obes Relat Metab Disord 1996; 20: 463–471.

    CAS  PubMed  Google Scholar 

  22. Taylor CB, Jatulis DE, Fortmann SP, Kraemer HC . Weight variability effects: a prospective analysis from the Stanford Five-City Project. Am J Epidemiol 1995; 141: 461–465.

    Article  CAS  Google Scholar 

  23. Itoh T, Horie S, Takahashi K, Okubo T . An evaluation of various indices of body weight change and their relationship with coronary risk factors. Int J Obes Relat Metab Disord 1996; 20: 1089–1096.

    CAS  PubMed  Google Scholar 

  24. Lee JS, Kawakubo K, Miyamoto K, Sasaki M . Body weight change and fluctuation effects on coronary risk factors in the Japanese middle aged men (in Japanese). Nippon Koshu Eisei Zasshi 1999; 46: 373–379.

    CAS  PubMed  Google Scholar 

  25. Targher G, Alberiche M, Zenere MB, Bonadonna RC, Muggeo M, Bonora E . Cigarette smoking and insulin resistance in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1997; 82: 3619–3624.

    CAS  PubMed  Google Scholar 

  26. Lu H, Buison A, Uhley V, Jen KL . Long-term weight cycling in female Wistar rats: effects on metabolism. Obes Res 1995; 3: 521–530.

    Article  CAS  Google Scholar 

  27. Sea MM, Fong WP, Huang Y, Chen ZY . Weight cycling-induced alteration in fatty acid metabolism. Am J Physiol Regul Integr Comp Physiol 2000; 279: R1145–R1155.

    Article  CAS  Google Scholar 

  28. Rodin J, Radke-Sharpe N, Rebuffe-Scrive M, Greenwood MR . Weight cycling and fat distribution. Int J Obes 1990; 14: 303–310.

    CAS  PubMed  Google Scholar 

  29. Iribarren C, Sharp DS, Burchfiel CM, Petrovitch H . Association of weight loss and weight fluctuation with mortality among Japanese American men. N Engl J Med 1995; 333: 686–692.

    Article  CAS  Google Scholar 

  30. Wedick NM, Mayer-Davis EJ, Wingard DL, Addy CL, Barrett-Connor E . Insulin resistance precedes weight loss in adults without diabetes: the Rancho Bernardo Study. Am J Epidemiol 2001; 153: 1199–1205.

    Article  CAS  Google Scholar 

  31. Gould AJ, Williams DE, Byrne CD, Hales CN, Wareham NJ . Prospective cohort study of the relationship of markers of insulin resistance and secretion with weight gain and changes in regional adiposity. Int J Obes Relat Metab Disord 1999; 23: 1256–1261.

    Article  CAS  Google Scholar 

  32. Zavaroni I, Zuccarelli A, Gasparini P, Massironi P, Barilli A, Reaven GM . Can weight gain in healthy, nonobese volunteers be predicted by differences in baseline plasma insulin concentration? J Clin Endocrinol Metab 1998; 83: 3498–3500.

    CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by Grant 13770192, 13470087, 12670352 from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan

    H Yatsuya, K Tamakoshi, Y Hori, H Zhang, M Ishikawa, T Kondo & H Toyoshima

  2. Department of Public Health, Fujita Health University, Toyoake, Japan

    T Yoshida

  3. Obesity Research Center, St. Luke's/Roosevelt Hospital Center, Columbia University College of Physicians & Surgeons, New York, NY, USA

    S Zhu

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Yatsuya, H., Tamakoshi, K., Yoshida, T. et al. Association between weight fluctuation and fasting insulin concentration in Japanese men. Int J Obes 27, 478–483 (2003). https://doi.org/10.1038/sj.ijo.0802221

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