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Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men

International Journal of Obesity volume 26, pages 1373–1378 (2002)Cite this article

Abstract

OBJECTIVE: The aim of the study was to investigate whether a long-lasting bout of exercise modifies the lipolytic β- and antilipolytic-α2-adrenergic effect and the antilipolytic effect of insulin in obese subjects.

DESIGN: Biopsies of abdominal subcutaneous adipose tissue were performed before and immediately after 2 h exercise (at 50% of VO2max) on an ergometric bicycle.

SUBJECTS: Nine healthy obese male subjects (mean age 38.0±3.5 y; mean body mass index (BMI) 35.6±3.9 kg/m2) were included in the experiment.

METHODS: The lipolytic responsiveness to adrenaline, isoprenaline (β-adrenergic agonist), UK-14304 (α2-adrenergic agonist) and insulin was studied in the isolated fat cell obtained by biopsies of subcutaneous adipose tissue from the peri-umbilical region before and after exercise.

RESULTS: After exercise, an increase was observed in spontaneous lipolytic rate, and in the lipolytic effect of isoprenaline, but no modification in the lipolytic action of adrenaline. Antilipolytic effects of UK-14304 and insulin were not changed by the single bout of exercise.

CONCLUSION: A single bout of long-term exercise increased the responsiveness of adipose tissue to β-adrenergic stimulation of lipolysis in obese subjects.

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Authors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale (INSERM, Unité 317), Université Paul Sabatier, Toulouse, France

    I Harant, F Marion-Latard, F Crampes, I de Glisezinski, M Berlan & D Rivière

  2. Laboratoire de Physiologie des Adaptations de I'Organisme à I'Exercice Musculaire et des Activités Posturocinétiques, CHU Purpan, Toulouse, France

    I Harant, F Marion-Latard, F Crampes, I de Glisezinski & D Rivière

  3. Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine, Toulouse, France

    M Berlan

  4. Department of Sport Medicine, Charles University, Prague, Czech Republic

    V Stich

Authors
  1. I Harant
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  2. F Marion-Latard
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  4. I de Glisezinski
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  5. M Berlan
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  6. V Stich
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  7. D Rivière
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Correspondence to I Harant.

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Harant, I., Marion-Latard, F., Crampes, F. et al. Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men. Int J Obes 26, 1373–1378 (2002). https://doi.org/10.1038/sj.ijo.0802072

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  • DOI: https://doi.org/10.1038/sj.ijo.0802072

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