Abstract
OBJECTIVE: As a result of efforts to isolate obesity-promoting genes, the Trp64Arg polymorphism in the β3 adrenergic receptor locus, has been studied by many investigators. Results of the studies have varied in statistical significance and magnitude of the association of the polymorphism with body mass index (BMI: kg/m2). This has led to controversy about whether this polymorphism is associated with meaningful changes in BMI. To clarify the possible association, we conducted a meta-analysis.
DESIGN: Meta-analytic study.
MEASUREMENTS: For each genotype of the β3 adrenergic receptor (Trp/Trp; Trp/Arg; Arg/Arg), we extracted the number of subjects, mean and standard deviation of BMI from 23 studies, including 36 different subgroups with a total of 7399 subjects. Other indices and obesity-related variables were not considered.
RESULTS: No significant association of the Trp64Arg polymorphism with BMI was found. The weighted mean BMI difference beween Trp/Trp homozygotes and Trp/Arg heterozygotes was 0.19 (s.e.=0.11; P=0.07). In addition, the distribution of effect sizes was not significantly heterogeneous (χ2=38.68; df 35; P=0.31) suggesting that the variation of the effect sizes across the subgroups is not significant. A further weighted regression analysis, utilizing all three genotypes and adjusting for the random subgroup effect, also showed the effect of the polymorphism on BMI is not significant (F=1.72, df=(2,54), P=0.19).
CONCLUSION: Based on existing data, the Trp64Arg polymorphism does not appear to be significantly associated with BMI. Moreover, we found no evidence for effect heterogeneity, suggesting that the effect of the polymorphism is not moderated by ethnicity or diabetic status.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Allison, D., Heo, M., Faith, M. et al. Meta-analysis of the association of the Trp64Arg polymorphism in the β3 adrenergic receptor with body mass index. Int J Obes 22, 559–566 (1998). https://doi.org/10.1038/sj.ijo.0800625
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ijo.0800625
Keywords
This article is cited by
-
From obesity genetics to the future of personalized obesity therapy
Nature Reviews Endocrinology (2013)
-
Lifestyle Modifies the Relationship Between Body Composition and Adrenergic Receptor Genetic Polymorphisms, ADRB2, ADRB3 and ADRA2B: A Secondary Analysis of a Randomized Controlled Trial of Physical Activity Among Postmenopausal Women
Behavior Genetics (2010)
-
Effect of the β3-adrenergic receptor gene polymorphism Trp64Arg on BMI reduction associated with an exercise-based intervention program in Japanese middle-aged males
Environmental Health and Preventive Medicine (2010)