Acta Pharmacologica Sinica

TABLE 2

FROM:

Inflammatory responses in hypoxic ischemic encephalopathy

Fudong Liu and Louise D McCullough

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Table 2. Roles of cytokines and chemokines in HIE.

MediatorsInvestigated objectsStimulationExpression after stimulationEffects on HIEReferences
IL-1αP7 ratsHIEUp-regulationDetrimental144
IL-1βP7 ratsHIEUp-regulationDetrimental144
 P7 ratsHIEUp-regulationDetrimental152
TNF-αP7 ratsHIEUp-regulationDetrimental152
IL-18P7 ratsHIEUp-regulationDetrimental153
 P9 IL-18−/− miceHIEN/ABeneficial in KO154
IL-2Children 4.5 years (average age)Perinatal strokeChronic up-regulationN/A155
IL-6P7 ratsHIEUp-regulationDetrimental152
IL-8Children 4.5 years (average age)Perinatal strokeChronic up-regulationN/A155
IL-9P5 miceIbotenate+IL-9N/ADetrimental156
IL-10P5 miceIbotenate+IL-10N/ABeneficial[157]
IL-4P5 miceIbotenate+IL-4N/ABeneficial156
IFN-γP1-3 ratsIFN-γ treatedN/ADetrimental[158]
CCL3/MIP-1αP7 ratsHIEUp-regulationDetrimental35
CCL4/MIP-1βP7 ratsHIEUp-regulationDetrimental35
CCL5/RANTESP7 ratsHIEUp-regulationDetrimental35
CCL2/MCP-1P7 ratsHIEUp-regulationDetrimental150
CXCL12/SDF1P7 miceHIEUp-regulationDetrimental63

 Data compared to the adults are not available.

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