Welcome to Acta Pharmacologica Sinica

As China's leading journal in pharmacology, APS offers high-quality, independently peer-reviewed research and review articles. Featured topics of particular interest include, but are not limited to, anticancer pharmacology, cardiovascular and pulmonary pharmacology, clinical pharmacology, drug discovery, gastrointestinal and hepatic pharmacology, genitourinary, renal and endocrine pharmacology, immunopharmacology and inflammation, molecular and cellular pharmacology, neuropharmacology, pharmaceutics and pharmacokinetics.

APS offers authors the option to publish their articles with immediate open access upon publication. Open access articles will also be deposited in PubMed Central at the time of publication and will be freely available immediately.

With an impact factor of 3.223* this journal brings cutting-edge research to an international readership.

Free online issue

Volume 38, No 7
July 2017

ISSN: 1671-4083
EISSN: 1745-7254

2016 Impact Factor 3.223*
55/166 Chemistry, Multidisciplinary
74/256 Pharmacology & Pharmacy

Jian Ding

*2016 Journal Citation Reports® Science Edition (Clarivate Analytics, 2017)


Cancer Precision Medicine

In this special issue, we have invited 7 reviews to discuss recent advances in precision cancer medicine, which include new PI3K/mTOR pathway inhibitors, endogenous angiogenesis inhibitors, NK cell-based cancer immunotherapy, microRNAs and alternative splicing as potential new diagnostic markers and cancer drug targets, and intra-tumor heterogeneity of cancer cells and their implications in cancer treatment. All of these studies support the new exciting development in cancer medicine in order to tailor effective cancer treatment precisely based on the molecular signatures of cancers in target. See articles marked $.

Nuclear Receptors: Biology, Structures, and Drug Discovery

The Jan 2015 issue of APS (Acta Pharmacologica Sinica) Nuclear receptors are DNA-binding and ligand-regulated transcriptional factors that play crucial roles in many aspects of human physiology and consist of an important family of drug targets. This year marked the 30th anniversary of the cloning of the first member of the nuclear receptor family and 25th year of the discovery of orphan nuclear receptors, for which no cognate ligands were known at the time of their cloning. Since then we have witnessed a tremendous expansion of our knowledge of this family of receptors. In this special issue, 11 review articles highlight our key understanding of structure, function, disease relevance, and drug discovery of nuclear receptors.

Stem cell therapy and drug discovery

The June 2013 issue of APS (Acta Pharmacologica Sinica) contains a special issue on Stem cell therapy and drug discovery that highlights both new findings and emerging ideas in different aspects of stem cell technologies, clinical therapies and drug discoveries.

Autophagy and Drug Discovery

The May 2013 issue of APS (Acta Pharmacologica Sinica) contains a special feature on Autophagy and Drug Discovery that includes 13 articles covering the important aspects of basic and clinical research on autophagy and reflecting on recent developments in this field. Further background information on this interesting topic is available through the accompanying web focus, which provides links to related articles from across Nature Publishing Group.


This issue covers our current understanding of the pathophysiological roles of the ion channels and exchangers involved in non-glutamate mechanisms in cerebral ischemia and stroke, as well as their potential for therapeutic intervention. These non-glutamate mechanisms include TRP channels, KATP channels, chloride channels, acid-sensing ion channels, hemichannels, volume-regulated anion channels, adenosine receptors, nitrogen species, neural precursor cells, retinal ischemia, and neuron glial cells. The articles highlight novel therapeutic strategies for targeting non-glutamate mechanisms to prevent neuronal damage in stroke and to promote neuronal survival, regeneration and functional recovery after stroke, thus providing long-term economic, social, and healthcare benefits worldwide.

G protein-coupled receptors

G protein-coupled receptors (GPCRs) are the largest family of cell surface communicating molecules. They facilitate diverse extracellular signals and, therefore, play a crucial role in numerous physiological processes and diseases. Subsequently, GPCRs have become drug targets for many major diseases. To date, however, only a small proportion of GPCRs have been investigated as targets, so this area still shows great potential in combatting many other diseases. The March 2012 issue contains a special feature on GPCRs including articles by leading experts on GPCR structures, biology, diseases, and drug discovery. Further background information on this important topic is available through the accompanying web focus which links to related articles from across Nature Publishing Group.


Obesity is the primary health threat of the 21st century. The last 30 years have seen a dramatic increase in the prevalence of obesity, especially in the developed countries. Such an increase has played a significant role on the overall health of these nations, and, in turn, has led to significant increases in healthcare expenditure. The February 2012 issue contains a special feature on Obesity including articles by leading experts on several topics that relate to obesity etiology, animal models, therapeutics and clinical implications. Further background information on this important topic is available through the accompanying web focus which links to related articles from across Nature Publishing Group.

Channelopathy and drug discovery

Channelopathies are diseases that result from functional disturbances of ion channels or the proteins that regulate them. The June special issue brings together a selection of articles dealing with the various ion channels, including aquaporins, potassium channels, chloride channels, sodium channels and calcium channels, that are involved in maladies such as cardiovascular disease, brain injury, reproductive disease and kidney disease and the recent advances that have been made in identifying potential drug targets for treating these diseases. The accompanying web focus presents additional links to related articles in this area from across Nature Publishing Group.

Celebrating the 30th Anniversary of APS

The 30th Anniversary Special Issue (September 2010) of APS brings together a series of thought-provoking Perspectives, Reviews and Original Articles on various outstanding issues in pharmacology today. This accompanying web focus provides a collection of recent developments in these fields. Select articles have been set free for a limited time.

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24 July 2017