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Nanoscale graphene oxide (NGO) has emerged as extremely attractive nanomaterials for diagnostics and therapeutics. In this work, we present a systematic study on the in vivo distribution and pulmonary toxicity of NGO for up to 3 months after exposure. Radioisotope tracing and morphological observation demonstrated that intratracheally instilled NGO was mainly retained in the lung. NGO could result in acute lung injury (ALI) and chronic pulmonary fibrosis, which raises environmental concerns about the large-scale production of graphene oxide. Nevertheless, we also noted that the NGO-induced ALI was related to oxidative stress and could effectively be relieved with dexamethasone treatment.
Modulating the drug release from polyester matrices independently from the material properties would be beneficial to those designing biodegradable medical implants, such as drug delivery devices, stents and screws. We propose that modulated drug release can be obtained via an additive-free mechanism in polyesters by simply controlling polymer erosion through acidic terminal functional groups. The formulations can be tuned to produce large ranges in drug release with relatively small changes in terminal acidic functional groups. For example, poly(lactic-co-glycolic acid) (PLGA) 53/47 thin films could be tuned to have 10–90% drug release at 20 days, depending on the concentration of acidic terminal groups.
We propose the simple and novel ‘aqueous route’ for realizing oxide thin-film transistors (TFTs) at low annealing temperatures <200 °C with low cost. These results provide substantial progress toward solution-processed metal-oxide TFT through naturally born unique indium complex and post annealing. They exhibit acceptable electrical performance with good large-area uniformity at low temperature. The additional vacuum annealing facilitates the condensation reaction by effective removal of byproduct water molecule and activates the In2O3 TFT at low temperature, even with 100 °C annealing. Also, we have demonstrated the flexible and transparent oxide TFTs on a plastic substrate with good stability to the external gate bias stress.
