American Journal of Hypertension

FIGURES AND TABLES

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Estrogen Deficiency-Induced Alterations of Vascular MMP-2, MT1-MMP, and TIMP-2 in Ovariectomized Rats

Kwok-Keung Lam, Pao-Yun Cheng, George Hsiao, Shu-Ying Chen, Hsin-Hsueh Shen, Mao-Hsiung Yen and Yen-Mei Lee

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

Figure 1.

Time course of mean blood pressure measured in conscious rats by the tail-cuff method; (a) 1–12 weeks after ovariectomy (Ovx); (b) Ovx rats with treatment of E2, tempol or aminoguanidine (AG) for 5 weeks beginning 1 week after Ovx. The initial number of animals is 18, and each week 3 rats were sacrificed for each time point. Data are given as means plusminus s.e.m., *P < 0.05 vs. sham. # P < 0.05 vs. Ovx.

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Figure 2.

Time course of changes in (a) collagen type I, (b) pro- and active MMP-2, (c) MT1-MMP, and (d) TIMP-2 protein expression in the aorta 1–12 weeks after ovariectomy (Ovx) in rats. Data are given as means plusminus s.e.m. (n = 3 for each time point). *P < 0.05 vs. sham. MMP, matrix metalloproteinase; MT1-MMP, membrane type 1-MMP; TIMP-2, tissue inhibitor of metalloproteinases-2.

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Figure 3.

Effects of E2 replacement on time course of changes in (a) collagen type I, (b) pro- and active MMP-2, (c) MT1-MMP, and (d) TIMP-2 protein expression in the aorta 2–7 weeks after ovariectomy (Ovx) in rats. Ovx: 2 weeks after Ovx. Ovx rats were injected with E2 (50 microg/kg per day, IM, once daily) for 1–6 weeks, beginning 1 week after Ovx. Data are given as means plusminus s.e.m. (n = 3 for each time point). *P < 0.05 vs. sham. # P < 0.05 vs. Ovx. MMP, matrix metalloproteinase; MT1-MMP, membrane type 1-MMP; TIMP-2, tissue inhibitor of metalloproteinases-2.

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Figure 4.

Effects of tempol treatment on time course of changes in (a) collagen type I, (b) pro- and active MMP-2, (c) MT1-MMP, and (d) TIMP-2 protein expression in the aorta 2–7 weeks after ovariectomy (Ovx) in rats. Ovx: 2 weeks after Ovx. Ovx rats were administered tempol (1 mmol/l in drinking water) for 1–6 weeks, beginning 1 week after Ovx. Data are given as means plusminus s.e.m. (n = 3 for each time point). *P < 0.05 vs. sham. # P < 0.05 vs. Ovx. MMP, matrix metalloproteinase; MT1-MMP, membrane type 1-MMP; TIMP-2, tissue inhibitor of metalloproteinases-2.

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Figure 5.

Effects of aminoguanidine (AG) treatment on time course of changes in (a) collagen type I, (b) pro- and active MMP-2, (c) MT1-MMP, and (d) TIMP-2 protein expression in the aorta 2–7 weeks after ovariectomy (Ovx) in rats. Ovx: 2 weeks after Ovx. Ovx rats were administered AG (1 mmol/l in drinking water) for 1–6 weeks, beginning 1 week after Ovx. Data are given as means plusminus s.e.m. (n = 3 for each time point). *P < 0.05 vs. sham. # P < 0.05 vs. Ovx. MMP, matrix metalloproteinase; MT1-MMP, membrane type 1-MMP; TIMP-2, tissue inhibitor of metalloproteinases-2.

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