Article
American Journal of Hypertension (2009); 22, 1, 68–73. doi:10.1038/ajh.2008.313
Hypertensive Status and Lipoprotein Oxidation in an Elderly Population at High Cardiovascular Risk
Mònica Guxens1,2,3, Montserrat Fitó1,4, Miguel-Angel Martínez-González5, Jordi Salas-Salvadó4,6, Ramón Estruch4,7, Ernest Vinyoles4,8, Miguel Fiol4,9, Dolores Corella4,10, Fernando Arós11, Enrique Gómez-Gracia12, Valentina Ruiz-Gutiérrez13, José Lapetra4,14, Emili Ros4,15, Joan Vila1 and María-Isabel Covas1,4
- 1Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d´Investigació Mèdica, Barcelona, Spain
- 2CIBER Epidemiologia y Salud Pública, Barcelona, Spain
- 3PhD Program in Public Health and Methodology of Biomedical Research, Universitat Autònoma de Barcelona, Spain
- 4CIBER Fisiopatología Obesidad y Nutrición, Santiago de Compostela, Spain
- 5Department of Preventive Medicine and Public Health, University of Navarra, Navarra, Spain
- 6Human Nutrition Unit, School of Medicine, University Rovira i Virgili, Reus, Spain
- 7Department of Internal Medicine, Hospital Clinic, Institut d´Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain
- 8Primary Health Care Division, Barcelona, Spain
- 9Institute for Health Sciences Investigation, Palma de Mallorca, Spain
- 10Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain
- 11Department of Cardiology, Hospital Txangorritxu, Vitoria, Spain
- 12Department of Epidemiology, School of Medicine of Malaga, Malaga, Spain
- 13Instituto de la Grasa, Sevilla, Spain
- 14Department of Epidemiology and Public Health, Hospital Virgen del Rocío, Sevilla, Spain
- 15Department of Endocrinology and Nutrition Service, Hospital Clinic, Institut d´Investigacions Biomèdiques August Pi Sunyer(IDIBAPS), Barcelona, Spain
Correspondence: María Isabel, (Covasmcovas@imim.es)
Received 31 May 2008; First Decision 24 July 2008; Accepted 25 September 2008; Published online 13 November 2008.
Abstract
Background
In elderly individuals, hypertension is a main risk factor for cardiovascular disease and oxidative damage is increased. Our aim was to assess the relationship between the degree of in vivo low-density lipoprotein (oxLDL) oxidation and the hypertensive status in a elderly population at high cardiovascular risk.
Methods
Cross-sectional study with baseline data from the PREDIMED (PREvención con DIeta MEDiterránea) trial, an intervention study directed at testing the efficacy of the Mediterranean diet on the primary prevention of cardiovascular disease. Participants were 1,130 subjects at high cardiovascular risk aged 55–80. At baseline, in vivo circulating oxLDL was measured, and stages of hypertension determined according to the USA Joint National Committee guidelines.
Results
A positive relationship between in vivo oxLDL and systolic and diastolic blood pressure (DBP) was observed after adjusting for confounding factors (P < 0.05). OxLDL concentrations increased in a linear manner from low to high hypertensive stages (P < 0.05).
Conclusions
Elderly individuals at high cardiovascular risk showed higher levels of circulating oxLDL when their hypertensive status increased. This fact identifies the hypertensive elderly population as a target for antioxidant preventive measures.
American Journal of Hypertension (2009). doi:10.1038/ajh.2008.313
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