Brief communication
Am J Hypertens (2004) 17, 1056–1058; doi: 10.1016/j.amjhyper.2004.06.018
A randomized, double-blind, placebo-controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension*
Raymond R. Townsend1, Christopher B. McFadden1, Virginia Ford1 and Jenny A. Cadée2
- 1Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania
- 2DMV International, Veghel, The Netherlands
Correspondence: Dr. Raymond R. Townsend, University of Pennsylvania, 210 White Building, 3400 Spruce Street, Philadelphia, PA 19104 E-mail: townsend@mail.med.upenn.edu
*Supported in part by an unrestricted grant from DMV International, The Netherlands.
Received 14 January 2004; Revised 26 May 2004; Accepted 13 June 2004.
Abstract
Background: Many patients seek complementary medicine treatments like neutraceuticals for common conditions such as hypertension.
Methods: We conducted a placebo-controlled prospective randomized crossover study in 10 hypertensive subjects to determine whether a single dose of a hydrolysate of bovine milk protein (designated C12 peptide; low and high dose), either alone or combined with alginic acid (low and high dose), reduced daytime blood pressure (BP), as determined by ambulatory BP monitoring.
Results: Within the five treatment regimens a significant reduction of 9.2
3.2 mm Hg in systolic BP at h 6 compared with h 2 occurred on the higher dose of alginic acid (1754 mg) combined with C12 (P = .02). The C12 peptide with the higher dose of alginic acid also showed a significant reduction of 6.0
2.0 mm Hg in diastolic BP at h 6 compared with h 2 (P = .015).
Conclusions: These preliminary data are encouraging and deserve testing in a larger and longer treatment trial.
Keywords:
Hypertension, caseins, complementary therapies
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