Brief Communication
Am J Hypertens (1997) 10, 786–789; doi: S0895-7061(97)00113-1
Angiotensin Converting Enzyme Gene Polymorphism in Essential Hypertension Based on Ambulatory Blood Pressure Monitoring
Yoshikazu Maeda1, Uichi Ikeda1, Hitoshi Ebata1, Yukihiro Hojo1, Yoshitane Seino1, Hironori Nakagami1 and Kazuyuki Shimada1
1Department of Cardiology, Jichi Medical School, Minamikawachi, Tochigi, Japan
Correspondence: Uichi Ikeda, MD, Department of Cardiology, Jichi Medical School, Minamikawachi, Tochigi 329-04, Japan; e-mail: uikeda@jichi.ac.jp
Received 0000; Revised 0000; Accepted 0000.
Abstract
The association of the angiotensin converting enzyme (ACE) gene polymorphism with essential hypertension is still controversial. We studied its polymorphism in 41 patients with hypertension based on ambulatory blood pressure (ABP) and 34 subjects with normal blood pressure. The ACE genotype was not significantly different between hypertensive and normotensive subjects. Casual blood pressure levels, 24 h, and daytime and nighttime ABP levels did not differ among the ACE genotype in patients with hypertension. In conclusion, the ACE genotype is not associated with essential hypertension based on ABP monitoring.
Keywords:
Angiotensin converting enzyme, hypertension, polymorphism
