TABLE OF CONTENTS

Volume 112, Issue 5 (May 2017)

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The Red Section

How I Approach It

Medication Management in the Pregnant IBD Patient

Sumona Saha MD, MS

Am J Gastroenterol 112: 667-669; advance online publication, February 21, 2017; doi:10.1038/ajg.2017.22

Point-Counterpoint

Therapeutic Drug Monitoring in IBD: Prospective Promise Unfulfilled

Shail M Govani MD, MSc and Akbar K Waljee MD, MSc

Am J Gastroenterol 112: 670-672; advance online publication, March 21, 2017; doi:10.1038/ajg.2017.63

Therapeutic Drug Monitoring in IBD: The New Standard-of-Care for Anti-TNF Therapy

Konstantinos Papamichael MD, PhD and Adam S Cheifetz MD

Am J Gastroenterol 112: 673-676; advance online publication, February 21, 2017; doi:10.1038/ajg.2017.21

Images of the Month

Metastatic Breast Cancer Mimicking a Solitary Small Colonic Erosion

Hiroyuki Aihara, Michael G Drage, Agoston Agoston and Christopher C Thompson

Am J Gastroenterol 112: 677; doi:10.1038/ajg.2016.575

Postoperative Eyelid Metastasis of a Gastric Cardia Adenocarcinoma

Gao-shi Huang and Yun Jin

Am J Gastroenterol 112: 677; doi:10.1038/ajg.2016.554

A Nipple Sign on an Ectopic Duodenal Varix

Sehem Ghazala, Kristen Barrett and Veronika Karasek

Am J Gastroenterol 112: 678; doi:10.1038/ajg.2016.598

Upper Endoscopy in Acute Coronary Syndrome With Ventricular Septal Perforation

Rintaro Hashimoto and Masato Nakahori

Am J Gastroenterol 112: 678; doi:10.1038/ajg.2016.613

Video of the Month

Endoscopic Submucosal Resection: A Novel Technique for Resection of a Small Gastric Stromal Tumor from the Muscularis Propria FREE

Lianyong Li, Sarah Cristofaro, Xiaojiang Zhou, Lin Xu, Changmin Qu, Shuwen Liang and Qiang Cai

Am J Gastroenterol 112: 679; doi:10.1038/ajg.2016.590

Urine Dripping From the Sigmoid Wall in a Patient With Suspected Crohn's Disease: An Unusual Manifestation of a Colonovesical Fistula FREE

Ren Mao, Ning Zhang, Yao He, Yi Cui, Shomron Ben-Horin and Min-hu Chen

Am J Gastroenterol 112: 680; doi:10.1038/ajg.2016.592

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Clinical Guidelines

Continuing Medical Education: April 2017

Am J Gastroenterol 112: 681; doi:10.1038/ajg.2017.109

Continuing Medical Education Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

Carol Durno, C Richard Boland, Shlomi Cohen, Jason A Dominitz, Frank M Giardiello, David A Johnson, Tonya Kaltenbach, T R Levin, David Lieberman, Douglas J Robertson and Douglas K Rex

Am J Gastroenterol 112: 682-690; advance online publication, March 28, 2017; doi:10.1038/ajg.2017.105

Continuing Medical Education Questions: April 2017

Renuka Umashanker MD, FACG,

Am J Gastroenterol 112: 691; doi:10.1038/ajg.2017.111

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Clinical and Systematic Reviews

Review

Continuing Medical Education: April 2017

Am J Gastroenterol 112: 692; doi:10.1038/ajg.2017.112

Review

Continuing Medical Education Central Neuromodulators for Treating Functional GI Disorders: A Primer

W Harley Sobin MD, Thomas W Heinrich MD, FAPM and Douglas A Drossman MD, MACG

Am J Gastroenterol 112: 693-702; advance online publication, March 28, 2017; doi:10.1038/ajg.2017.57

Subject Category: Clinical and Systematic Review

Review

Continuing Medical Education Questions: April 2017

Edith Y Ho MD

Am J Gastroenterol 112: 703; doi:10.1038/ajg.2017.113

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Original Contributions

Stomach

A Serological Biopsy Using Five Stomach-Specific Circulating Biomarkers for Gastric Cancer Risk Assessment: A Multi-Phase Study

Huakang Tu MD, PhD, Liping Sun MD, PhD, Xiao Dong MD, MS, Yuehua Gong MD, PhD, Qian Xu MD, PhD, Jingjing Jing MD, Roberd M Bostick MD, MPH, Xifeng Wu MD, PhD and Yuan Yuan MD, PhD

Am J Gastroenterol 112: 704-715; advance online publication, March 21, 2017; doi:10.1038/ajg.2017.55

Subject Category: Stomach

Endoscopy

Ocular Radiation Threshold Projection Based off of Fluoroscopy Time During ERCP

Mrinal S Garg MD, Pikul Patel MD, Margaret Blackwood MS, DABR, Satish Munigala MD, MPH, Payal Thakkar PharmD, James Field MD, Dustin Wallace MD, Satty Agarwal MD, Elie Aoun MD, Abhijit Kulkarni MD, Manish Dhawan MD, Katie Farah MD and Shyam Thakkar MD

Am J Gastroenterol 112: 716-721; advance online publication, December 13, 2016; doi:10.1038/ajg.2016.540

See also: Original Contribution by Mekaroonkamol

Subject Category: Endoscopy

Editorial: ERCP-Related Radiation Cataractogenesis: Is It Time to Be Concerned?

Parit Mekaroonkamol MD and Steven Keilin MD, FASGE

Am J Gastroenterol 112: 722-724; doi:10.1038/ajg.2017.100

See also: Original Contribution by Garg et al.

Subject Category: Endoscopy

Cap Assisted Upper Endoscopy for Examination of the Major Duodenal Papilla: A Randomized, Blinded, Controlled Crossover Study (CAPPA Study)

Mohamed Abdelhafez MD, Veit Phillip MD, Alexander Hapfelmeier PhD, Mayada Elnegouly MD, PhD, Alexander Poszler MD, Kilian Strobel, Peter Born MD, Markus Dollhopf MD, Abdel Meguid Kassem MD, PhD, Lenika Calavrezos MD, Peter Klare MD, Christoph Schlag MD, Monther Bajbouj MD, Roland M Schmid MD and Stefan von Delius MD

Am J Gastroenterol 112: 725-733; advance online publication, March 14, 2017; doi:10.1038/ajg.2017.47

Subject Category: Endoscopy

A Comparison of the Rate of Gastrointestinal Bleeding in Patients Taking Non-Vitamin K Antagonist Oral Anticoagulants or Warfarin

David J Cangemi MD, Timothy Krill MD, Rick Weideman PharmD, Daisha J Cipher PhD, Stuart J Spechler MD and Linda A Feagins MD

Am J Gastroenterol 112: 734-739; advance online publication, February 28, 2017; doi:10.1038/ajg.2017.39

Subject Category: Endoscopy

Liver

Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis Open

Stuart McPherson BSc, MBChB, MD, FRCP, Tim Hardy BSc, MBBS, Jean-Francois Dufour MD, PhD, Salvatore Petta MD, PhD, Manuel Romero-Gomez MD, PhD, Mike Allison BSc(Hons), MD, PhD, Claudia P Oliveira MD, PhD, Sven Francque MD, PhD, Luc Van Gaal MD, PhD, Jörn M Schattenberg MD, PhD, Dina Tiniakos MD, PhD, Alastair Burt BSc (Hons), MBChB, MD (Hons), FRCPath, FRCP, FRCPA, FRSB, F AcadMEd, FAHMS, Elisabetta Bugianesi MD, PhD, Vlad Ratziu MD, PhD, Christopher P Day MA, MB BChir, MD, PhD, FRCP, FRCPE, FMedSci and Quentin M Anstee BSc, MB BS, PhD, FRCP

Am J Gastroenterol 112: 740-751; advance online publication, October 11, 2016; doi:10.1038/ajg.2016.453

See also: Original Contribution by Stine

Subject Category: Liver

Editorial: Age and Non-Invasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease: Time to Adjust the Clock?

Jonathan G Stine MD, MSc, FACP and Mary E Rinella MD

Am J Gastroenterol 112: 752-754; doi:10.1038/ajg.2017.60

See also: Original Contribution by McPherson et al.

Subject Category: Liver

Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty Liver Disease in Midlife

Monika Sarkar MD, MAS, Melissa Wellons MD, Marcelle I Cedars MD, Lisa VanWagner MD, MSc, Erica P Gunderson PhD, Veeral Ajmera MD, MAS, Laura Torchen MD, David Siscovick MD, MPH, J Jeffrey Carr MD, MSc, James G Terry MS, Mary Rinella MD, Cora E Lewis MD, MSPH and Norah Terrault MD for the Coronary Artery Risk Development in Young Adults (CARDIA) Cohort

Am J Gastroenterol 112: 755-762; advance online publication, March 14, 2017; doi:10.1038/ajg.2017.44

Subject Category: Liver

Functional GI Disorders

Tenapanor Treatment of Patients With Constipation-Predominant Irritable Bowel Syndrome: A Phase 2, Randomized, Placebo-Controlled Efficacy and Safety Trial Open

William D Chey MD, AGAF, FACG, FACP, RFF, Anthony J Lembo MD and David P Rosenbaum PhD

Am J Gastroenterol 112: 763-774; advance online publication, February 28, 2017; doi:10.1038/ajg.2017.41

Subject Category: Functional GI Disorders

Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus Open

Ali Rezaie MD, MSc, FRCP(C), Michelle Buresi MD, Anthony Lembo MD, Henry Lin MD, Richard McCallum MD, Satish Rao MD, Max Schmulson MD, Miguel Valdovinos MD, Salam Zakko MD and Mark Pimentel MD, FRCP(C) on behalf of The North American Consensus group on hydrogen and methane-based breath testing

Am J Gastroenterol 112: 775-784; advance online publication, March 21, 2017; doi:10.1038/ajg.2017.46

Subject Category: Functional GI Disorders

Colon/Small Bowel

Risk for Incomplete Resection after Macroscopic Radical Endoscopic Resection of T1 Colorectal Cancer: A Multicenter Cohort Study

Y Backes MD, W H de Vos tot Nederveen Cappel MD, PhD, J van Bergeijk MD, PhD, F ter Borg MD, PhD, M P Schwartz MD, PhD, B W M Spanier MD, PhD, J M J Geesing MD, K Kessels MD, M Kerkhof MD, PhD, J N Groen MD, F H J Wolfhagen MD, PhD, T C J Seerden MD, PhD, N van Lelyveld MD, PhD, G J A Offerhaus MD, PhD, P D Siersema MD, PhD, M M Lacle MD, PhD and L M G Moons MD, PhD (on behalf of the Dutch T1 CRC Working Group)

Am J Gastroenterol 112: 785-796; advance online publication, March 21, 2017; doi:10.1038/ajg.2017.58

Subject Category: Colon/Small Bowel

Pancreas and Biliary Tract

Early Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis

James L Buxbaum MD, Michael Quezada MD, Ben Da MD, Niraj Jani MD, Christianne Lane PhD, Didi Mwengela MD, Thomas Kelly MD, Paul Jhun MD, Kiran Dhanireddy MD and Loren Laine MD

Am J Gastroenterol 112: 797-803; advance online publication, March 7, 2017; doi:10.1038/ajg.2017.40

Subject Category: Pancreas/Biliary Tract

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Letters to the Editor

Pancreatic Cystic Neoplasms: To Needle or Not To Needle, This Is the Question

Marco Del Chiaro MD, PhD, Urban Arnelo MD, PhD and Roberto Valente MD

Am J Gastroenterol 112: 804; doi:10.1038/ajg.2016.552

See also: Letter to the Editor by Farrell

Response to Del Chiaro et al.

James J Farrell MD

Am J Gastroenterol 112: 804-805; doi:10.1038/ajg.2017.51

See also: Letter to the Editor by Del Chiaro et al.

Proton Pump Inhibitors and Clostridium difficile Infection

Hemant Goyal MD, FACP and Harold Katner MD

Am J Gastroenterol 112: 805; doi:10.1038/ajg.2016.600

See also: Letter to the Editor by Faleck

Response to Goyal and Katner

David M Faleck MD and Daniel E Freedberg MD, MS

Am J Gastroenterol 112: 806; doi:10.1038/ajg.2017.65

See also: Letter to the Editor by Goyal

Vitamin D’s Role in Non-Alcoholic Fatty Liver Disease

Hyun-seok Kim MD, MPH, Laura Rotundo MD and Mirela Feurdean MD

Am J Gastroenterol 112: 806-807; doi:10.1038/ajg.2016.602

See also: Letter to the Editor by Patel et al.

Reply to Kim et al.

Yuval A Patel MD, Ricardo Henao PhD, Cynthia A Moylan MD, MHS, Cynthia D Guy MD, Dawn L Piercy FNP-BC, MS, Anna Mae Diehl MD, FAASLD and Manal F Abdelmalek MD, MPH, FAASLD

Am J Gastroenterol 112: 807-808; doi:10.1038/ajg.2017.45

See also: Letter to the Editor by Kim et al.

Did Carvedilol Really Have More Severe Adverse Events than Propranolol in Cirrhotic Patients?

Gin-Ho Lo MD

Am J Gastroenterol 112: 808; doi:10.1038/ajg.2017.3

See also: Letter to the Editor by Kim

Response to Lo et al.

Sang G Kim MD, PhD and Joo H Sohn MD, PhD

Am J Gastroenterol 112: 808-809; doi:10.1038/ajg.2017.50

See also: Letter to the Editor by Lo

Lack in Standardized Reporting of Biliary Stents: A Meta-Analysis Complicated by the Inconsistency

Tsuyoshi Hamada MD, PhD, Ryunosuke Hakuta MD, Yousuke Nakai MD, PhD, Hiroyuki Isayama MD, PhD and Kazuhiko Koike MD, PhD

Am J Gastroenterol 112: 809-810; doi:10.1038/ajg.2016.585

See also: Letter to the Editor by Almadi et al.

Response to Hamada et al.

Majid A Almadi MBBS, MSc, FRCPC, Alan Barkun MD, CM, MSc, FRCPC and Myriam Martel BSc

Am J Gastroenterol 112: 810-811; doi:10.1038/ajg.2017.66

See also: Letter to the Editor by Hamada et al.

Laryngeal Reflux and Symptoms Need Further Elucidation Using New Techniques

Lijuan Song MD, Wenjing Liao BA, Yingshen Lu MD, Pingchang Yang MD, PhD, Nanshan Zhong MD, PhD and Xiaowen Zhang MD, PhD

Am J Gastroenterol 112: 811-812; doi:10.1038/ajg.2017.25

See also: Letter to the Editor by Yadlapati et al.

Response to Song et al.

Rena Yadlapati MD, John E Pandolfino MD, MS and Bruce K Tan MD, MS

Am J Gastroenterol 112: 812-813; doi:10.1038/ajg.2017.67

See also: Letter to the Editor by Song et al.

Improving Outcomes of Chronic Pancreatitis: Is Isolated Pancreatic Exocrine Insufficiency an Early Marker to Identify Modifiable Risks?

Andrew D Hopper MD, FRCP, Jennifer A Campbell MRCP and David S Sanders MD, FRCP

Am J Gastroenterol 112: 813-814; doi:10.1038/ajg.2017.59

Racial Differences in Chronic Pancreatitis. An Explanation for South America?

Zoltán Berger MD, PhD and Carla Mancilla MD

Am J Gastroenterol 112: 814-815; doi:10.1038/ajg.2017.99

Novel Technique to Manage Recurrent PEG-J Tube Dislodgement With Full-Thickness Endoscopic Suturing

Abhishek Agnihotri MBBS, Sindhu Barola MBBS, Jamie Flickinger MSN, Mouen A Khashab MD and Vivek Kumbhari MD

Am J Gastroenterol 112: 815-816; doi:10.1038/ajg.2017.94

Acute Life-Threatening Portal Hypertension After Portosystemic Shunt Embolization

Saad A Khan MBBS, Cecilia Pham MBBS, Dean Seah MBBS, Dinesh Ranatunga MBBS, FRANZCR, EBIR and Paul J Gow MD, FRACP

Am J Gastroenterol 112: 816-818; doi:10.1038/ajg.2017.62

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Announcements

Calendar of Courses, Symposiums, and Conferences

Am J Gastroenterol 112: 819; doi:10.1038/ajg.2017.92