TABLE OF CONTENTS

Volume 107, Issue 4 (April 2012)

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The Red Section

Increasing Complexity of Clinical Research in Gastroenterology: Implications for the Training of Clinician-Scientists

Frank I Scott MD, Ryan A McConnell MD, Matthew E Lewis and James D Lewis MD, MSCE

Am J Gastroenterol 107: 496-500; doi:10.1038/ajg.2011.450

How the FDA Manages Drug Safety With Black Box Warnings, Use Restrictions, and Drug Removal, With Attention to Gastrointestinal Medications

Eli D Ehrenpreis MD, Arthur A Ciociola PhD, Prasad M Kulkarni MD, FACG and the FDA-Related Matters Committee of the American College of Gastroenterology

Am J Gastroenterol 107: 501-504; doi:10.1038/ajg.2011.449

Images of the Month

Am J Gastroenterol 107: 505; doi:10.1038/ajg.2012.64

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Clinical and Systematic Reviews

Review

Continuing Medical Education: April 2012

Am J Gastroenterol 107: 506; doi:10.1038/ajg.2012.83

Subject Category: Clinical and Systematic Review

Continuing Medical Education Proton Pump Inhibitors vs. Histamine 2 Receptor Antagonists for Stress-Related Mucosal Bleeding Prophylaxis in Critically Ill Patients: A Meta-Analysis

Alan N Barkun MD, MSc, Marc Bardou MD, PhD, C Q D Pham PharmD and Myriam Martel BSc

Am J Gastroenterol 107: 507-520; advance online publication, January 31, 2012; doi:10.1038/ajg.2011.474

Subject Category: Clinical and Systematic Review

Continuing Medical Education Questions: April 2012

Kenneth R DeVault MD, FACG, William Cooney MD and Anoop Prabhu MD

Am J Gastroenterol 107: 521; doi:10.1038/ajg.2012.85

Subject Category: Clinical and Systematic Review

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Original Contributions

Esophagus

Efficacy of Twice-Daily Rabeprazole for Reflux Esophagitis Patients Refractory to Standard Once-Daily Administration of PPI: The Japan-Based TWICE Study

Yoshikazu Kinoshita MD, PhD and Michio Hongo MD, PhD The Japan TWICE Study Group

Am J Gastroenterol 107: 522-530; advance online publication, March 20, 2012; doi:10.1038/ajg.2012.19

See also: Original Contribution by Fass et al.

Subject Category: Esophagus

Editorial: Healing Erosive Esophagitis With a Proton Pump Inhibitor: The More the Merrier?

Ronnie Fass MD, FACG

Am J Gastroenterol 107: 531-533; doi:10.1038/ajg.2012.25

See also: Original Contribution by Kinoshita et al.

Subject Category: Esophagus

Surveillance and Follow-Up Strategies in Patients With High-Grade Dysplasia in Barrett's Esophagus: A Dutch Population-Based Study

Romy E Verbeek MD, Martijn G H van Oijen MD, Fiebo J W ten Kate MD, PhD, Frank P Vleggaar MD, Marguerite E I Schipper, Mariel K Casparie MD, Jantine W P M van Baal MD and Peter D Siersema MD, PhD

Am J Gastroenterol 107: 534-542; advance online publication, January 24, 2012; doi:10.1038/ajg.2011.459

Subject Category: Esophagus

Endoscopy

Feasibility and Accuracy of Confocal Endomicroscopy in Comparison With Narrow-Band Imaging and Chromoendoscopy for the Differentiation of Colorectal Lesions

T Kuiper, F J C van den Broek, S van Eeden, P Fockens and E Dekker MD, PhD

Am J Gastroenterol 107: 543-550; advance online publication, March 20, 2012; doi:10.1038/ajg.2012.14

See also: Original Contribution by Ussui et al.

Subject Category: Endoscopy

Editorial: Imaged-Enhanced Technologies for Colorectal Polyp Detection and Classification

Vivian M Ussui MD and Michael B Wallace MD, MPH

Am J Gastroenterol 107: 551-553; doi:10.1038/ajg.2012.15

See also: Original Contribution by Kuiper et al.

Subject Category: Endoscopy

Detection of Lesions During Capsule Endoscopy: Physician Performance Is Disappointing

YuanPu Zheng BS, Lauren Hawkins MD, Jordan Wolff MD, Olga Goloubeva PhD, Msc and Eric Goldberg MD

Am J Gastroenterol 107: 554-560; advance online publication, January 10, 2012; doi:10.1038/ajg.2011.461

Subject Category: Endoscopy

Liver

Ultrasonographically Detected Non-Alcoholic Fatty Liver Disease Is an Independent Predictor for Identifying Patients With Insulin Resistance in Non-Obese, Non-Diabetic Middle-Aged Asian Adults

Dong Hyun Sinn MD, Geum-Youn Gwak MD, PhD, Ha Na Park MD, Jee Eun Kim MD, Yang Won Min MD, Kwang Min Kim MD, Yu Jin Kim MD, Moon Seok Choi MD, PhD, Joon Hyeok Lee MD, PhD, Kwang Cheol Koh MD, PhD, Seung Woon Paik MD, PhD and Byung Chul Yoo MD, PhD

Am J Gastroenterol 107: 561-567; advance online publication, November 22, 2011; doi:10.1038/ajg.2011.400

Subject Category: Liver

Continuing Medical Education: April 2012

Am J Gastroenterol 107: 568; doi:10.1038/ajg.2012.84

Subject Category: Liver

Continuing Medical Education Radiofrequency Ablation for Hepatocellular Carcinoma: 10-Year Outcome and Prognostic Factors Open

Shuichiro Shiina MD, PhD, Ryosuke Tateishi MD, PhD, Toru Arano MD, Koji Uchino MD, Kenichiro Enooku MD, PhD, Hayato Nakagawa MD, PhD, Yoshinari Asaoka MD, PhD, Takahisa Sato MD, PhD, Ryota Masuzaki MD, PhD, Yuji Kondo MD, PhD, Tadashi Goto MD, PhD, Haruhiko Yoshida MD, PhD, Masao Omata MD, PhD and Kazuhiko Koike MD, PhD

Am J Gastroenterol 107: 569-577; advance online publication, December 13, 2011; doi:10.1038/ajg.2011.425

Subject Category: Liver

Continuing Medical Education Questions: April 2012

Kenneth R DeVault MD, FACG, Mihir K Patel MD, MSc and Bashar Qumseya MD

Am J Gastroenterol 107: 578; doi:10.1038/ajg.2012.86

Subject Category: Liver

Inflammatory Bowel Disease

Has There Been a Change in the Natural History of Crohn's Disease? Surgical Rates and Medical Management in a Population-Based Inception Cohort from Western Hungary Between 1977–2009

Peter Laszlo Lakatos MD, PhD, Petra Anna Golovics MsC, Gyula David MD, Tunde Pandur MD, Zsuzsanna Erdelyi MD, Agnes Horvath MD, Gabor Mester MD, Mihaly Balogh MD, Istvan Szipocs MD, Csaba Molnar MD, Erzsebet Komaromi MD, Gabor Veres MD, PhD, Barbara Dorottya Lovasz MsC, Miklos Szathmari MD, DsC, Lajos S Kiss MD and Laszlo Lakatos MD, PhD

Am J Gastroenterol 107: 579-588; advance online publication, January 10, 2012; doi:10.1038/ajg.2011.448

Subject Category: Inflammatory Bowel Disease

Clinical and Genetic Risk Factors for Perianal Crohn's Disease in a Population-Based Cohort

T W Eglinton MBChB, FRACS, R Roberts BSc (Hons) I, PhD, J Pearson BSc, MSc, PhD, M Barclay MBChB, MD, FRACP, T R Merriman PhD, F A Frizelle MBChB, M Med Sc, FACS, FRACS and R B Gearry MBChB, PhD, FRACP

Am J Gastroenterol 107: 589-596; advance online publication, December 13, 2011; doi:10.1038/ajg.2011.437

Subject Category: Inflammatory Bowel Disease

Functional GI Disorders

Fecal Incontinence in Systemic Sclerosis Is Secondary to Neuropathy

Nora M Thoua BSc, MBBS, MRCP, Mostafa Abdel-Halim MSc, MRCS, Alastair Forbes BSc, MD, FRCP, FHEA, Chris P Denton PhD, FRCP and Anton V Emmanuel BSc, MD, FRCP

Am J Gastroenterol 107: 597-603; advance online publication, November 15, 2011; doi:10.1038/ajg.2011.399

Subject Category: Functional GI Disorders

Colon/Small Bowel

Impaired Control of Effector T Cells by Regulatory T Cells: A Clue to Loss of Oral Tolerance and Autoimmunity in Celiac Disease?

Nadia Belhadj Hmida MSc, Mélika Ben Ahmed MD, PhD, Amel Moussa MD, Majd Ben Rejeb MD, Yosra Said MD, Nadia Kourda MD, Bertrand Meresse PhD, Maha Abdeladhim MSc, Hechmi Louzir MD and Nadine Cerf-Bensussan MD, PhD

Am J Gastroenterol 107: 604-611; advance online publication, November 22, 2011; doi:10.1038/ajg.2011.397

Subject Category: Colon/Small Bowel

Pancreas and Biliary Tract

A Comparative Evaluation of Radiologic and Clinical Scoring Systems in the Early Prediction of Severity in Acute Pancreatitis

Thomas L Bollen MD, Vikesh K Singh MD, MSc, Rie Maurer MA, Kathryn Repas BA, Hendrik W van Es MD, Peter A Banks MD and Koenraad J Mortele MD

Am J Gastroenterol 107: 612-619; advance online publication, December 20, 2011; doi:10.1038/ajg.2011.438

Subject Category: Pancreas/Biliary Tract

Use of Antidiabetic Agents and the Risk of Pancreatic Cancer: A Case–Control Analysis

Michael Bodmer MSc, MD, Claudia Becker PhD, Christian Meier MD, Susan S Jick and Christoph R Meier

Am J Gastroenterol 107: 620-626; advance online publication, January 31, 2012; doi:10.1038/ajg.2011.483

Subject Category: Pancreas/Biliary Tract

Pediatrics

Long-Term Follow-Up of Gut-Directed Hypnotherapy vs. Standard Care in Children With Functional Abdominal Pain or Irritable Bowel Syndrome

Arine M Vlieger MD, PhD, Juliette M T M Rutten MD, Anita M A P Govers MD, Carla Frankenhuis and Marc A Benninga MD, PhD

Am J Gastroenterol 107: 627-631; advance online publication, February 7, 2012; doi:10.1038/ajg.2011.487

Subject Category: Pediatrics

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Letters to the Editor

Fluid Volume in Acute Pancreatitis: How Much Is Too Much?

Jeffrey Sanders MD, Amar R Deshpande MD, Jamie S Barkin MD and Daniel A Sussman MD

This letter underwent AJG editorial review.

Am J Gastroenterol 107: 632; doi:10.1038/ajg.2012.24

See also: Letter to the Editor by de-Madaria et al.

Response to Sanders et al.

Enrique de-Madaria MD, PhD, Juan Martínez MD, PhD and Miguel Pérez-Mateo MD, PhD

This letter underwent AJG editorial review.

Am J Gastroenterol 107: 632-633; doi:10.1038/ajg.2012.30

See also: Letter to the Editor by Sanders et al.

Potential Hazards of Submucosal Injection of Methylene Blue

Erick P Chan MD, Tonya Kaltenbach MD, Robert V Rouse MD and Roy Soetikno MD

This letter underwent AJG editorial review.

Am J Gastroenterol 107: 633-634; doi:10.1038/ajg.2011.462

Commentary on “Risk Factors for Early-Onset and Late-Onset Hepatocellular Carcinoma in Asian Immigrants With Hepatitis B in the United States”

Seyed Moayed Alavian MD and Seyed Mohammad Jazayeri MD, PhD

This letter underwent AJG editorial review.

Am J Gastroenterol 107: 635; doi:10.1038/ajg.2012.22

Weekend Effect in Non-Variceal Upper Gastrointestinal Bleeding: Data From Nine Italian Gastrointestinal Units

Marco Soncini MD, Fausto Chilovi MD, Omero Triossi MD and Pietro Leo MD

This letter underwent AJG editorial review.

Am J Gastroenterol 107: 635-636; doi:10.1038/ajg.2011.431

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Announcements

Calendar of Courses, Symposiums, and Conferences

Am J Gastroenterol 107: 637; doi:10.1038/ajg.2012.51

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Errata, Corrigenda and Retractions

Corrigendum: Assessing Possible Celiac Disease by an HLA-DQ2-Gliadin Tetramer Test FREE

M Brottveit, M Raki, E Bergseng, L-E Fallang, B Simonsen, A Lovik, S Larsen, E M Loberg, F L Jahnsen, L M Sollid and K E A Lundin

Am J Gastroenterol 107: 638; doi:10.1038/ajg.2012.43

Erratum: Images of the Month FREE

Am J Gastroenterol 107: 638; doi:10.1038/ajg.2012.77

Corrigendum: Prescription of and Adherence to Non-Steroidal Anti-Inflammatory Drugs and Gastroprotective Agents in At-Risk Gastrointestinal Patients FREE

Angel Lanas, Mónica Polo-Tomás, Pilar Roncales, Miguel A. Gonzalez and Javier Zapardiel

Am J Gastroenterol 107: 639; doi:10.1038/ajg.2012.76