TABLE OF CONTENTS

Volume 106, Issue 4 (April 2011)

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The Red Section

Who Wants to Take a Thiopurine Holiday?

Peter D R Higgins MD, PhD, MSc

Am J Gastroenterol 106: 556-558; doi:10.1038/ajg.2010.483

TNF-α and the Development of the Neonatal Immune System: Implications for Inhibitor Use in Pregnancy

Razvan Arsenescu MD, Violeta Arsenescu MD, PhD and Willem J S de Villiers MD, PhD

Am J Gastroenterol 106: 559-562; doi:10.1038/ajg.2011.5

Dietary Intake and Risk of Developing Inflammatory Bowel Disease: A Systematic Review of the Literature

Jason K Hou MD, Bincy Abraham MD, MS and Hashem El-Serag MD, MPH

Am J Gastroenterol 106: 563-573; doi:10.1038/ajg.2011.44

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Practice Guidelines

Consensus for Managing Acute Severe Ulcerative Colitis in Children: A Systematic Review and Joint Statement From ECCO, ESPGHAN, and the Porto IBD Working Group of ESPGHAN

Dan Turner MD, PhD, Simon P L Travis FRCP, Anne M Griffiths MD, Frank M Ruemmele MD, PhD, Arie Levine MD, Eric I Benchimol MD, PhD, Marla Dubinsky MD, George Alex MBBS, FRACP, PhD, Robert N Baldassano MD, Jacob C Langer MD, Robert Shamberger MD, Jeffrey S Hyams MD, Salvatore Cucchiara MD, PhD, Athos Bousvaros MD, MPH, Johanna C Escher MD, PhD, James Markowitz MD, David C Wilson MD, Gert van Assche MD, PhD and Richard K Russell PhD

Am J Gastroenterol 106: 574-588; advance online publication, January 11, 2011; doi:10.1038/ajg.2010.481

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Clinical and Systematic Reviews

Review

Continuing Medical Education: April 2011

Am J Gastroenterol 106: 589; doi:10.1038/ajg.2011.98

Subject Category: Clinical and Systematic Review

Continuing Medical Education Glucocorticosteroid Therapy in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis

Alexander C Ford MBChB, MD, MRCP, Charles N Bernstein MD, Khurram J Khan MD, FRCPC, Maria T Abreu MD, John K Marshall MD, MSc, FRCPC, Nicholas J Talley MD, PhD and Paul Moayyedi BSc, MBChB, PhD, MPH, FRCP, FRCPC

Am J Gastroenterol 106: 590-599; advance online publication, March 15, 2011; doi:10.1038/ajg.2011.70

Subject Category: Clinical and Systematic Review

Continuing Medical Education Questions: April 2011

Kenneth R DeVault MD, Reena Khanna MD and Lay Lay Win MBBS

Am J Gastroenterol 106: 600; doi:10.1038/ajg.2011.99

Subject Category: Clinical and Systematic Review

Efficacy of 5-Aminosalicylates in Ulcerative Colitis: Systematic Review and Meta-Analysis

Alexander C Ford MBChB, MD, MRCP, Jean-Paul Achkar MD, Khurram J Khan MD, FRCPC, Sunanda V Kane MD, MSPH, Nicholas J Talley MD, PhD, John K Marshall MD, MSc, FRCPC and Paul Moayyedi BSc, MBChB, PhD, MPH, FRCP, FRCPC

Am J Gastroenterol 106: 601-616; advance online publication, March 15, 2011; doi:10.1038/ajg.2011.67

Subject Category: Clinical and Systematic Review

Efficacy of 5-Aminosalicylates in Crohn's Disease: Systematic Review and Meta-Analysis

Alexander C Ford MBChB, MD, MRCP, Sunanda V Kane MD, MSPH, Khurram J Khan MD, FRCPC, Jean-Paul Achkar MD, Nicholas J Talley MD, PhD, John K Marshall MD, MSc, FRCPC and Paul Moayyedi BSc, MBChB, PhD, MPH, FRCP, FRCPC

Am J Gastroenterol 106: 617-629; advance online publication, March 15, 2011; doi:10.1038/ajg.2011.71

Subject Category: Clinical and Systematic Review

Efficacy of Immunosuppressive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Khurram J Khan MD, FRCPC, Marla C Dubinsky MD, Alexander C Ford MD, MRCP, Thomas A Ullman MD, FACG, Nicholas J Talley MD, PhD, FACG and Paul Moayyedi MB ChB, BSc, MPH, PhD, FACG

Am J Gastroenterol 106: 630-642; advance online publication, March 15, 2011; doi:10.1038/ajg.2011.64

Subject Category: Clinical and Systematic Review

Continuing Medical Education: April 2011

Am J Gastroenterol 106: 643; doi:10.1038/ajg.2011.96

Subject Category: Clinical and Systematic Review

Continuing Medical Education Efficacy of Biological Therapies in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis

Alexander C Ford MBChB, MD, MRCP, William J Sandborn MD, Khurram J Khan MD, FRCPC, Stephen B Hanauer MD, Nicholas J Talley MD, PhD and Paul Moayyedi BSc, MBChB, PhD, MPH, FRCP, FRCPC

Am J Gastroenterol 106: 644-659; advance online publication, March 15, 2011; doi:10.1038/ajg.2011.73

Subject Category: Clinical and Systematic Review

Continuing Medical Education Questions: April 2011

Kenneth R DeVault MD, Susan Coe MD and Yize Wang MD

Am J Gastroenterol 106: 660; doi:10.1038/ajg.2011.97

Subject Category: Clinical and Systematic Review

Antibiotic Therapy in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Khurram J Khan MD, Thomas A Ullman MD, FACG, Alexander C Ford MD, MRCP, Maria T Abreu MD, FACG, A Abadir MD, John K Marshall MD, MSc, FRCPC, Nicholas J Talley MD, PhD, FACG and Paul Moayyedi MB, ChB, BSc, MPH, PhD, FACG

Am J Gastroenterol 106: 661-673; advance online publication, March 15, 2011; doi:10.1038/ajg.2011.72

Subject Category: Clinical and Systematic Review

Loss of Response and Need for Adalimumab Dose Intensification in Crohn's Disease: A Systematic Review

Vincent Billioud MD, William J Sandborn MD and Laurent Peyrin-Biroulet MD, PhD

Am J Gastroenterol 106: 674-684; advance online publication, March 15, 2011; doi:10.1038/ajg.2011.60

Subject Category: Clinical and Systematic Review

Assessing Response and Loss of Response to Biological Therapies in IBD

Henit Yanai MD and Stephen B Hanauer MD

Am J Gastroenterol 106: 685-698; advance online publication, March 22, 2011; doi:10.1038/ajg.2011.103

Subject Category: Clinical and Systematic Review

The Prognostic Power of the NOD2 Genotype for Complicated Crohn's Disease: A Meta-Analysis

Jeremy Adler MD, MSc, Sujal C Rangwalla DO, Ben A Dwamena MB, ChB and Peter DR Higgins MD, PhD, MSc

Am J Gastroenterol 106: 699-712; advance online publication, February 22, 2011; doi:10.1038/ajg.2011.19

Subject Category: Clinical and Systematic Review

Venous Thromboembolism in Inflammatory Bowel Disease: An Epidemiological Review

Sanjay K Murthy MD, FRCPC and Geoffrey C Nguyen MD, PhD, FRCPC

Am J Gastroenterol 106: 713-718; advance online publication, March 15, 2011; doi:10.1038/ajg.2011.53

Subject Category: Clinical and Systematic Review

Molecular Pathways Underlying IBD-Associated Colorectal Neoplasia: Therapeutic Implications

Gati A Goel MD, PhD, Ahmed Kandiel MD, MPH, Jean Paul Achkar MD and Bret Lashner MD, MPH

Am J Gastroenterol 106: 719-730; advance online publication, March 8, 2011; doi:10.1038/ajg.2011.51

Subject Category: Clinical and Systematic Review

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Original Contributions

Inflammatory Bowel Disease

5-Aminosalicylate Is Not Chemoprophylactic for Colorectal Cancer in IBD: A Population Based Study

Charles N Bernstein MD, Zoann Nugent PhD and James F Blanchard MD, PhD

Am J Gastroenterol 106: 731-736; advance online publication, March 15, 2011; doi:10.1038/ajg.2011.50

See also: Original Contribution by Terdiman et al.

Subject Category: Inflammatory Bowel Disease

The Prevention of Colitis-Related Cancer by 5-Aminosalicylates: An Appealing Hypothesis that Remains Unproven

Jonathan P Terdiman MD

Am J Gastroenterol 106: 737-740; doi:10.1038/ajg.2011.56

See also: Original Contribution by Bernstein et al.

Subject Category: Inflammatory Bowel Disease

Inflammatory Bowel Disease Is Associated With an Increased Incidence of Cardiovascular Events

Andres J Yarur MD, Amar R Deshpande MD, David M Pechman BS, Leonardo Tamariz MD, MPH, Maria T Abreu MD and Daniel A Sussman MD

Am J Gastroenterol 106: 741-747; advance online publication, March 8, 2011; doi:10.1038/ajg.2011.63

Subject Category: Inflammatory Bowel Disease

Mucosal Gene Expression of Cell Adhesion Molecules, Chemokines, and Chemokine Receptors in Patients With Inflammatory Bowel Disease Before and After Infliximab Treatment

Ingrid Arijs PhD, Gert De Hertogh MD, PhD, Kathleen Machiels MS, Kristel Van Steen PhD, Katleen Lemaire PhD, Anica Schraenen PhD, Leentje Van Lommel MS, Roel Quintens MS, Gert Van Assche MD, PhD, Séverine Vermeire MD, PhD, Frans Schuit MD, PhD and Paul Rutgeerts MD, PhD

Am J Gastroenterol 106: 748-761; advance online publication, February 15, 2011; doi:10.1038/ajg.2011.27

Subject Category: Inflammatory Bowel Disease

Infliximab Therapy Inhibits Inflammation-Induced Angiogenesis in the Mucosa of Patients With Crohn's Disease

Sergio Rutella MD, PhD, Gionata Fiorino MD, Stefania Vetrano BSc, Carmen Correale BSc, Antonino Spinelli MD, Nico Pagano MD, Vincenzo Arena MD, Nicola Maggiano BSc, Alessandro Repici MD, Alberto Malesci MD and Silvio Danese MD, PhD

Am J Gastroenterol 106: 762-770; advance online publication, March 1, 2011; doi:10.1038/ajg.2011.48

Subject Category: Inflammatory Bowel Disease

Successive Treatment With Cyclosporine and Infliximab in Steroid-Refractory Ulcerative Colitis

S Leblanc MD, M Allez MD, PhD, P Seksik MD, PhD, B Flourié MD, H Peeters MD, J L Dupas MD, G Bouguen MD, L Peyrin-Biroulet MD, PhD, B Duclos MD, A Bourreille MD, PhD, O Dewit MD, Y Bouhnik MD, PhD, P Michetti MD, PhD, S Chaussade MD, PhD, P Saussure MD, J Y Mary PhD, J F Colombel MD, PhD and M Lémann MD, PhD and the GETAID

Am J Gastroenterol 106: 771-777; advance online publication, March 8, 2011; doi:10.1038/ajg.2011.62

Subject Category: Inflammatory Bowel Disease

Tolerability of Shortened Infliximab Infusion Times in Patients With Inflammatory Bowel Diseases: A Single-Center Cohort Study

Christine Breynaert MD, Marc Ferrante MD, PhD, Herma Fidder MD, PhD, Kristel Van Steen PhD, Maja Noman MD, Vera Ballet MSc, Séverine Vermeire MD, PhD, Paul Rutgeerts MD, PhD and Gert Van Assche MD, PhD

Am J Gastroenterol 106: 778-785; advance online publication, March 15, 2011; doi:10.1038/ajg.2011.61

Subject Category: Inflammatory Bowel Disease

A Single Dose of Intravenous Zoledronate Prevents Glucocorticoid Therapy-Associated Bone Loss in Acute Flare of Crohn's Disease, a Randomized Controlled Trial

Jochen Klaus MD, M M Haenle MD, C Schröter MD, G Adler, G von Boyen MD, M Reinshagen and C von Tirpitz MD

Am J Gastroenterol 106: 786-793; advance online publication, March 8, 2011; doi:10.1038/ajg.2011.59

Subject Category: Inflammatory Bowel Disease

Perceived and Actual Quality of Life With Ulcerative Colitis: A Comparison of Medically and Surgically Treated Patients

Akbar K Waljee MD, MSc, Peter D R Higgins MD, PhD, MSc, Jennifer F Waljee MD, MPH, MS, Shannan R Tujios MD, Aditi Saxena MD, Lindsay K Brown BA, Meghana N Chaudhary MS and Arden M Morris MD, MPH

Am J Gastroenterol 106: 794-799; advance online publication, March 1, 2011; doi:10.1038/ajg.2011.39

Subject Category: Inflammatory Bowel Disease

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Letters to the Editor

Variability in Pathogenesis and Treatment of Ischemic Colitis

Tetsuji Fujita MD

Am J Gastroenterol 106: 800; doi:10.1038/ajg.2010.467

See also: Letter to the Editor by Feuerstadt et al.

Response to Fujita

Paul Feuerstadt MD and Lawrence J Brandt MD

Am J Gastroenterol 106: 800-801; doi:10.1038/ajg.2010.468

See also: Letter to the Editor by Fujita et al.

For EUSGuided FNA of Solid Pancreatic Masses, Bigger Is Not Always Better

Uzma D Siddiqui MD and Harry R Aslanian MD

Am J Gastroenterol 106: 801-802; doi:10.1038/ajg.2010.499

See also: Letter to the Editor by Song et al.

Response to Siddiqui and Aslanian

Tae Jun Song MD and Sang Soo Lee MD, PhD

Am J Gastroenterol 106: 802; doi:10.1038/ajg.2010.501

See also: Letter to the Editor by Siddiqui et al.

Using Reimbursement to Improve Colonoscopy Quality

Ronald E Feldman MD, FACG, AGAF, FASGE

Am J Gastroenterol 106: 802-803; doi:10.1038/ajg.2011.8

See also: Letter to the Editor by Rex et al.

Response to Feldman

Douglas K Rex MD, FACG, AGAF, FASGE and David G Hewett MBBS, MSc, PhD, FRACP

Am J Gastroenterol 106: 803; doi:10.1038/ajg.2011.13

See also: Letter to the Editor by Feldman et al.

Prevention of Clostridium difficile Infections: Efficacious and High-Quality Probiotics Can Produce the Expected Effect When Used Appropriately

Mathieu Millette PhD, Eric Simard PhD and Serge Carrière MD

Am J Gastroenterol 106: 804; doi:10.1038/ajg.2010.494

Pulmonary Capillaritis: A Rare Extra-Intestinal Manifestation of Inflammatory Bowel Disease

Jesse M Civan MD, Christopher R Gilbert DO and David M Kastenberg MD

Am J Gastroenterol 106: 804-805; doi:10.1038/ajg.2011.46

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Announcements

Calendar of Courses, Symposiums, and Conferences

Am J Gastroenterol 106: 806; doi:10.1038/ajg.2011.69