TABLE OF CONTENTS

Volume 104, Issue 6 (June 2009)

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The Red Section

Meeting Report

Green Light from the FDA for New Drug Development in Irritable Bowel Syndrome and Functional Dyspepsia

Nicholas J Talley MD, PhD

Am J Gastroenterol 104: 1339-1341; doi:10.1038/ajg.2009.295

A Matter of Opinion

Helicobacter pylori Eradication and Gastric Cancer: When Is the Horse Out of the Barn?

A C de Vries MD, PhD, E J Kuipers MD, PhD and E A J Rauws MD, PhD

Am J Gastroenterol 104: 1342-1345; doi:10.1038/ajg.2008.15

Risk Management

Most Doctors Win: What to Do If Sued for Medical Malpractice

Andrew D Feld MD, JD and Richard E Moses DO, JD

Am J Gastroenterol 104: 1346-1351; doi:10.1038/ajg.2009.215

Reflections on Medical Practice

Quality Medical Care in Gastroenterology: Lessons From Palliative Medicine

Larry D Scott MD, MA

Am J Gastroenterol 104: 1352-1355; doi:10.1038/ajg.2009.142

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Original Contributions

Esophagus

Receipt of Previous Diagnoses and Endoscopy and Outcome From Esophageal Adenocarcinoma: A Population-Based Study With Temporal Trends

Gregory S Cooper MD, Tzyung Doug Kou PhD and Amitabh Chak MD

Am J Gastroenterol 104: 1356-1362; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.159

Subject Category: Esophagus

Editorial: Where Are You and How Do We Find You? The Dilemma of Identifying Barrett's Epithelium Before Adenocarcinoma of the Esophagus

Roy K H Wong MD and Sean F Altekruse DVM

Am J Gastroenterol 104: 1363-1365; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.167

Subject Category: Esophagus

Properties of the Neosquamous Epithelium After Radiofrequency Ablation of Barrett's Esophagus Containing Neoplasia

Roos E Pouw MD, Joep J Gondrie MD, PhD, Agnieszka M Rygiel MD, PhD, Carine M Sondermeijer BSc, Fiebo J ten Kate MD, PhD, Robert D Odze MD, PhD, Michael Vieth MD, PhD, Kausilia K Krishnadath MD, PhD and Jacques J Bergman MD, PhD

Am J Gastroenterol 104: 1366-1373; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.88

Subject Category: Esophagus

Endoscopy

Novel Removable Internally Fully Covered Self-Expanding Metal Esophageal Stent: Feasibility, Technique of Removal, and Tissue Response in Humans

Mohamad A Eloubeidi MD, MHS, FACG and Tercio L Lopes MD, MSPH

Am J Gastroenterol 104: 1374-1381; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.133

Subject Category: Endoscopy

Liver and Biliary Tract

Hyponatremia Is a Risk Factor of Hepatic Encephalopathy in Patients With Cirrhosis: A Prospective Study With Time-Dependent Analysis

Mónica Guevara, M E Baccaro, Aldo Torre, Beatriz Gómez-Ansón, José Ríos, Ferrán Torres, Lorena Rami, Gemma C Monté-Rubio, Marta Martín-Llahí, Vicente Arroyo and Pere Ginès

Am J Gastroenterol 104: 1382-1389; advance online publication, May 19, 2009; doi:10.1038/ajg.2009.293

Subject Category: Liver and Biliary Tract

Editorial: Hyponatremia in Hepatic Encephalopathy:
An Accomplice or Innocent Bystander?

Byung Cheol Yun MD and W Ray Kim MD

Am J Gastroenterol 104: 1390-1391; advance online publication, May 19, 2009; doi:10.1038/ajg.2009.287

Subject Category: Liver and Biliary Tract

Performance of the Hepatic Encephalopathy Scoring Algorithm in a Clinical Trial of Patients With Cirrhosis and Severe Hepatic Encephalopathy

Tarek Hassanein MD, Andres T Blei MD, William Perry PhD, Robin Hilsabeck PhD, Jan Stange MD, Fin S Larsen MD, Robert S Brown Jr MD, Stephen Caldwell MD, Brendan McGuire MD, Frederik Nevens MD and Robert Fontana MD

Am J Gastroenterol 104: 1392-1400; advance online publication, May 19, 2009; doi:10.1038/ajg.2009.160

Subject Category: Liver and Biliary Tract

The Utility of Evaluating Low Serum Albumin Gradient Ascites in Patients With Cirrhosis

Hashim E Khandwalla MD, Yemi Fasakin MD and Hashem B El-Serag MD, MPH

Am J Gastroenterol 104: 1401-1405; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.117

Subject Category: Liver and Biliary Tract

Common Genetic Variation and Haplotypes of the Anion Exchanger SLC4A2 in Primary Biliary Cirrhosis

Brian D Juran BS, Elizabeth J Atkinson MS, Joseph J Larson BS, Erik M Schlicht BA and Konstantinos N Lazaridis MD

Am J Gastroenterol 104: 1406-1411; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.103

Subject Category: Liver and Biliary Tract

Chronic Liver Disease Mortality Among Male Prison Inmates in Texas, 1989–2003

Amy Jo Harzke MDiv, MPH, DrPH, Jacques Baillargeon PhD, David P Paar MD, John Pulvino PA and Owen J Murray DO

Am J Gastroenterol 104: 1412-1419; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.106

Subject Category: Liver and Biliary Tract

The Serological Profile of the Autoimmune Hepatitis/Primary Biliary Cirrhosis Overlap Syndrome

Paolo Muratori MD, Alessandro Granito MD, Georgios Pappas MD, Gaspare M Pendino MD, Chiara Quarneti MD, Ronny Cicola, Rita Menichella MD, Silvia Ferri MD, Fabio Cassani MD, Francesco B Bianchi MD, Marco Lenzi MD and Luigi Muratori MD, PhD

Am J Gastroenterol 104: 1420-1425; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.126

Subject Category: Liver and Biliary Tract

Inflammatory Bowel Disease

Novel Anti-Glycan Antibodies Related to Inflammatory Bowel Disease Diagnosis and Phenotype

Cynthia H Seow MBBS, FRACP, MSc, Joanne M Stempak MSc, CCRP, Wei Xu PhD, P Stat, Hui Lan PhD, Anne M Griffiths MD, FRCPC, Gordon R Greenberg MD, FRCPC, A Hillary Steinhart MD, FRCPC, MSc, Nir Dotan PhD and Mark S Silverberg MD, FRCPC, PhD

Am J Gastroenterol 104: 1426-1434; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.79

Subject Category: Inflammatory Bowel Disease

Characterization of Inflammatory Bowel Disease With Urinary Metabolic Profiling

Horace R T Williams MRCP, I Jane Cox PhD, David G Walker MRCP, Bernard V North PhD, Venisha M Patel BSc, Sara E Marshall PhD FRCP, Derek P Jewell DPhil, FRCP, Subrata Ghosh MD, FRCP, Huw J W Thomas PhD, FRCP, Julian P Teare MD, FRCP, Simon Jakobovits MRCP, Sebastian Zeki MRCP, Kenneth I Welsh PhD, Simon D Taylor-Robinson MD, FRCP and Timothy R Orchard MD, FRCP

Am J Gastroenterol 104: 1435-1444; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.175

Subject Category: Inflammatory Bowel Disease

Risk of Arterial Thrombotic Events in Inflammatory Bowel Disease

Christina Ha MD, Simon Magowan MD, Neil A Accortt PhD, Jiajing Chen MPH and Christian D Stone MD, MPH

Am J Gastroenterol 104: 1445-1451; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.81

Subject Category: Inflammatory Bowel Disease

Safety and Efficacy of a New 3.3 g b.i.d. Tablet Formulation in Patients With Mild-to-Moderately-Active Ulcerative Colitis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

Ellen J Scherl MD, Ronald Pruitt MD, Glenn L Gordon MD, Mark Lamet MD, Audrey Shaw PhD, Shirley Huang MS, Shadreck Mareya PhD and William P Forbes PharmD

Am J Gastroenterol 104: 1452-1459; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.83

Subject Category: Inflammatory Bowel Disease

Rapid Recurrence of IBD-Associated Anemia and Iron Deficiency After Intravenous Iron Sucrose and Erythropoietin Treatment

Stefanie Kulnigg MD, Lena Teischinger, Clemens Dejaco MD, Thomas Waldhör PhD and Christoph Gasche MD

Am J Gastroenterol 104: 1460-1467; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.114

Subject Category: Inflammatory Bowel Disease

The Efficacy and Tolerability of AST-120 (Spherical Carbon Adsorbent) in Active Pouchitis

Bo Shen MD, Darrell S Pardi MD, Ana E Bennett MD, Elaine Queener LPN, Patricia Kammer CCRP, Jefferey P Hammel MS, Caroline LaPlaca MS and M Scott Harris MD

Am J Gastroenterol 104: 1468-1474; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.138

Subject Category: Inflammatory Bowel Disease

Functional GI Disorders

Selective Serotonin Reuptake Inhibitors Are Associated With a Modest Increase in the Risk of Upper Gastrointestinal Bleeding

Laura E Targownik MD, MSHS, James M Bolton MD, Colleen J Metge PhD, Stella Leung MSc and Jitender Sareen MD

Am J Gastroenterol 104: 1475-1482; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.128

Subject Category: Functional GI Disorders

Minimum Clinically Important Difference for the Nepean Dyspepsia Index, a Validated Quality of Life Scale for Functional Dyspepsia

Michael Jones PhD and Nicholas J Talley MD, PhD

Am J Gastroenterol 104: 1483-1488; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.136

Subject Category: Functional GI Disorders

A Treatment Trial of Acupuncture in IBS Patients

Anthony J Lembo MD, Lisa Conboy ScD, John M Kelley PhD, Rosa S Schnyer, Claire A McManus, Mary T Quilty, Catherine E Kerr PhD, Doug Drossman MD, Eric E Jacobson PhD, Roger B Davis ScD and Ted J Kaptchuk OMD

Am J Gastroenterol 104: 1489-1497; advance online publication, May 19, 2009; doi:10.1038/ajg.2009.156

Subject Category: Functional GI Disorders

Colon/Small Bowel

Combining Autofluorescence Imaging and Narrow-Band Imaging for the Differentiation of Adenomas from Non-Neoplastic Colonic Polyps Among Experienced and Non-Experienced Endoscopists

Frank J C van den Broek MD, Ellert J van Soest MD, Anton H Naber MD, PhD, Arnoud H A M van Oijen MD, Rosalie Ch Mallant-Hent MD, PhD, Clarisse J M Böhmer MD, PhD, Pieter Scholten MD, Pieter C F Stokkers MD, PhD, Willem A Marsman MD, PhD, Elisabeth M H Mathus-Vliegen MD, PhD, Wouter L Curvers MD, Jacques J G H M Bergman MD, PhD, Susanne van Eeden MD, PhD, James C H Hardwick MD, PhD, Paul Fockens MD, PhD, Johannes B Reitsma MD, PhD and Evelien Dekker MD, PhD

Am J Gastroenterol 104: 1498-1507; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.161

Subject Category: Colon/Small Bowel

Development and Validation of a Colon Cancer Risk Assessment Tool for Patients Undergoing Colonoscopy

Fay Kastrinos MD, MPH, John I Allen MD, MBA, David H Stockwell MD, MPH, Elena M Stoffel MD, MPH, Earl F Cook ScD, Muthoka L Mutinga MD, Judith Balmaña MD and Sapna Syngal MD, MPH

Am J Gastroenterol 104: 1508-1518; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.135

Subject Category: Colon/Small Bowel

Pancreas

Symptomatic Pancreatitis in Patients With Cystic Fibrosis

Ian Gooding MRCP, Emma Bradley, Joanne Puleston MRCP, Khin-Ma Gyi FRCP, Margaret Hodson FRCP and David Westaby FRCP

Am J Gastroenterol 104: 1519-1523; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.127

Subject Category: Pancreas

Pathology

The Current Spectrum of Gastric Polyps: A 1-Year National Study of over 120,000 Patients

Susanne W Carmack MD, Robert M Genta MD, Christopher M Schuler MD and M Hossein Saboorian MD

Am J Gastroenterol 104: 1524-1532; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.139

Subject Category: Pathology

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Clinical Reviews

Review

A Meta-Analysis of the Diagnostic Accuracy of Esophageal Capsule Endoscopy for Barrett's Esophagus in Patients With Gastroesophageal Reflux Disease

Atul Bhardwaj MD, Christopher S Hollenbeak PhD, Nakechand Pooran MD and Abraham Mathew MD

Am J Gastroenterol 104: 1533-1539; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.86

Continuing Medical Education Continuing Medical Education: June 2009

Am J Gastroenterol 104: 1540; doi:10.1038/ajg.2009.317

The Safety of Proton Pump Inhibitors (PPIs) in Pregnancy: A Meta-Analysis

Simerpal K Gill, Lisa O'Brien, Thomas R Einarson and Gideon Koren MD, FRCPC

Am J Gastroenterol 104: 1541-1545; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.122

Continuing Medical Education Questions: June 2009

James S Scolapio MD, Muhammad K Hasan MD, Anna M Buchner MD and Kanwar R S Gill MD

Am J Gastroenterol 104: 1546; doi:10.1038/ajg.2009.297

Continuing Medical Education Continuing Medical Education: June 2009

Am J Gastroenterol 104: 1547; doi:10.1038/ajg.2009.298

Meta-Analysis of Randomized Clinical Trials Comparing Open and Laparoscopic Anti-Reflux Surgery

Matthew James Peters BSc, MBBS, Athar Mukhtar MBBS, MRCS, Rossita Mohamad Yunus MSc, Shahjahan Khan PhD, Juanita Pappalardo BPharm MBBS (Hons), Breda Memon RGN, LLB, PGC Ed and Muhammed Ashraf Memon MBBS, MA Clin Ed, DCH, FRACS, FRCSI, FRCSEd, FRCSEng

Am J Gastroenterol 104: 1548-1561; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.176

Continuing Medical Education Questions: June 2009

James S Scolapio MD, Karen C Kim MD, Ying Hong Wang MD, Ashish Atreja MD and Dian Chiang MD

Am J Gastroenterol 104: 1562; doi:10.1038/ajg.2009.299

Electrosurgery in Gastrointestinal Endoscopy: Principles to Practice

Marcia L Morris MS, Robert D Tucker PhD, MD, Todd H Baron MD and Louis M Wong Kee Song MD

Am J Gastroenterol 104: 1563-1574; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.105

Use of Infliximab in Particular Clinical Settings: Management Based on Current Evidence

Alfredo Papa MD, Giammarco Mocci MD, Michele Bonizzi MD, Carla Felice MD, Gianluca Andrisani MD, Italo De Vitis MD, Luisa Guidi MD and Antonio Gasbarrini MD

Am J Gastroenterol 104: 1575-1586; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.162

Between Celiac Disease and Irritable Bowel Syndrome: The "No Man's Land" of Gluten Sensitivity

Elena F Verdu MD, PhD, David Armstrong MA, MB, BChir and Joseph A Murray MD

Am J Gastroenterol 104: 1587-1594; advance online publication, May 19, 2009; doi:10.1038/ajg.2009.188

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Letters to the Editor

Proton Pump Inhibitors After Endoscopy in Peptic Ulcer Bleeding

Hwai-Jeng Lin MD, FACG

Am J Gastroenterol 104: 1595; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.130

Response to Lin

Angelo Andriulli MD and Riccardo Marmo MD

Am J Gastroenterol 104: 1595-1596; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.131

Video-Recording Documentation of Colonoscopy

Anil Minocha MD, FACG

Am J Gastroenterol 104: 1596-1597; advance online publication, May 19, 2009; doi:10.1038/ajg.2009.141

Response to Minocha

Douglas K Rex MD, FACG

Am J Gastroenterol 104: 1597-1598; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.145

High-Risk and Advanced Adenoma: Who Is the Real Target of CT Colonography Screening?

C Hassan MD, A Laghi MD, A Zullo MD, F Iafrate MD and E Di Giulio MD

Am J Gastroenterol 104: 1598-1599; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.166

Advanced vs. "High-Risk" Adenomas: Identifying the Relevant Target for CT Colonography Screening

Perry J Pickhardt MD and David H Kim MD

Am J Gastroenterol 104: 1599-1600; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.205

Response to Hassan et al.

D K Rex MD, FACG

Am J Gastroenterol 104: 1600; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.169

Diagnostic Performance of Esophageal pH Electrodes at Different Locations

Jerry D Gardner MD

Am J Gastroenterol 104: 1601; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.192

Response to Gardner

Jörgen Wenner MD, PhD and Stefan Öberg MD, PhD

Am J Gastroenterol 104: 1601-1602; advance online publication, May 19, 2009; doi:10.1038/ajg.2009.194

Aspiration of Video Capsule: Rare but Potentially Life-Threatening Complication to Include in Your Consent Form

A Koulaouzidis MD, J Pendlebury BSc, S Douglas BSc and JN Plevris MD, PhD

Am J Gastroenterol 104: 1602-1603; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.93

Urinary Bladder Metastasis from an Esophageal Adenocarcinoma: A Case Report

J P Schuurman MD, T S de Vries Reilingh MD, PhD, S M Roothaan MD, R Th Bijleveld MD and M J Wiezer MD, PhD

Am J Gastroenterol 104: 1603-1604; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.113

Thrombophilia in Liver Disease

Weekitt Kittisupamongkol MD

Am J Gastroenterol 104: 1604; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.124

Splenic Injury as a Complication of Colonoscopy: A Case Series

Kiran V Rao MD, Gagan D Beri MD, Mark J Sterling MD and Gerald Salen MD

Am J Gastroenterol 104: 1604-1605; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.94

Erosive Gastritis Mimicking Watermelon Stomach

Osman Yüksel MD, Seyfettin Köklü MD, Ömer Bas cedilar MD, I dotlhami Yüksel MD and Hikmet Akgül MD

Am J Gastroenterol 104: 1606-1607; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.108

Oral Fleet Phospho-Soda Laxative Induced Symptomatic Hypocalcemia in an Adult Patient With Celiac Disease

Erkin Oztas MD, Mehmet Bektas MD, Mevlut Kurt MD, Ibrahim Koral Onal MD and Ali Ozden MD

Am J Gastroenterol 104: 1607-1608; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.119

Monthly and Seasonal Birth Patterns and the Occurrence of Crohn's Disease

Erika Angelucci MD, Andrea Cocco MD, Monica Cesarini MD, Annalisa Crudeli MD, Stefano Necozione MD, Renzo Caprilli MD and Giovanni Latella MD

Am J Gastroenterol 104: 1608-1609; advance online publication, April 21, 2009; doi:10.1038/ajg.2009.107

Development of Pouchitis With Combination Therapy With Peg-Interferon alpha-2b and Ribavirin for Chronic Hepatitis C in a Patient With Ulcerative Colitis Who Underwent Pouch Surgery

Kenichi Morimoto MD, Hirokazu Yamagami MD, PhD, Shuhei Hosomi MD, PhD, Mizuki Ohira MD, Takehisa Suekane MD, PhD, Noriko Kamata MD, PhD, Mitsue Sogawa MD, PhD, Kenji Watanabe MD, PhD, Kazunari Tominaga MD, PhD, Toshio Watanabe MD, PhD, Yasuhiro Fujiwara MD, PhD, Akihiro Tamori MD, PhD, Nobuhide Oshitani MD, PhD and Tetsuo Arakawa MD, PhD, FACG

Am J Gastroenterol 104: 1609-1610; advance online publication, April 28, 2009; doi:10.1038/ajg.2009.120

Acute Hemorrhage With Retroperitoneal Hematoma After Endoscopic Ultrasound-Guided Fine-Needle Aspiration of an Intraductal Papillary Mucinous Neoplasm of the Pancreas

Silvia Carrara MD, Paolo Giorgio Arcidiacono MD, Antonella Giussani MD and Pier Alberto Testoni PhD

Am J Gastroenterol 104: 1610-1611; advance online publication, May 12, 2009; doi:10.1038/ajg.2009.132

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Announcements

Calendar of Courses, Symposiums, and Conferences

Am J Gastroenterol 104: 1612; doi:10.1038/ajg.2009.272

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Errata, Corrigenda and Retractions

Corrigendum: American College of Gastroenterology Guidelines for Colorectal Cancer Screening 2008 FREE

Douglas K Rex, David A Johnson, Joseph C Anderson, Phillip S Schoenfeld, Carol A Burke and John M Inadomi

Am J Gastroenterol 104: 1613; doi:10.1038/ajg.2009.265

Corrigendum: Remifentanil vs. Meperidine for Patient-Controlled Analgesia During Colonoscopy: A Randomized Double-Blind Trial FREE

Lorella Fanti, Agostoni Massimo, Gemma Marco, Gambino Giulia, Facciorusso Antonio, Guslandi Mario, Torri Giorgio and Testoni Pier Alberto

Am J Gastroenterol 104: 1613; doi:10.1038/ajg.2009.266

Corrigendum: Pathogenesis of and Unifying Hypothesis for Idiopathic Pouchitis FREE

J Calvin Coffey, Fiachra Rowan, John Burke, Neil Dochery, William O Kirwan and P Ronan O'Connell

Am J Gastroenterol 104: 1613; doi:10.1038/ajg.2009.294

Erratum: False-Positive Wireless Video Capsule Secondary to Performing a Simultaneous Sigmoidoscopy FREE

Arthur D Shiff, Suryakanth Gurudu, G Anton Decker and Jonathan A Leighton

Am J Gastroenterol 104: 1613; doi:10.1038/ajg.2009.278

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