TABLE OF CONTENTS

Volume 103, Issue 12 (December 2008)

Top

The Red Section

Debate

EBM: Savior or Scourge of Clinical Practice

Am J Gastroenterol 103: 2965; doi:10.1111/j.1572-0241.2008.02193_1.x

PRO

PRO: EBM: An Invaluable Tool for Medical Practice

Philip S Schoenfeld MD, M.S.Ed., M.Sc. (Epi)

Am J Gastroenterol 103: 2965-2967; doi:10.1111/j.1572-0241.2008.02193_2.x

CON

CON: Evidence-Based Medicine—The Emperor's New Clothes?

Paul Moayyedi BSc, MB ChB, PhD, MPH FRCP (London), FRCPC, AGAF, FACG

Am J Gastroenterol 103: 2967-2969; doi:10.1111/j.1572-0241.2008.02193_3.x

A Balancing View

A Balancing View: Evidence-Based Medicine: Neither Savior Nor Scourge but a Practical Tool for Clinical Practice

Yuhong Yuan MD PhD and Richard H Hunt MB, FRCP, FRCPC, FACG, AGAF

Am J Gastroenterol 103: 2969-2971; doi:10.1111/j.1572-0241.2008.02193_4.x

A Matter of Opinion

Bacterial Overgrowth and Irritable Bowel Syndrome: Unifying Hypothesis or a Spurious Consequence of Proton Pump Inhibitors?

Brennan M R Spiegel MD, MSHS, William D Chey MD and Lin Chang MD

Am J Gastroenterol 103: 2972-2976; doi:10.1111/j.1572-0241.2008.01992.x

Top

Original Contributions

Esophagus

Wireless pH Recording Immediately Above the Squamocolumnar Junction Improves the Diagnostic Performance of Esophageal pH Studies

Jörgen Wenner MD, PhD, Mats Hall MD, Peter Höglund MD, PhD, Jan Johansson MD, PhD, Folke Johnsson MD, PhD and Stefan Öberg MD, PhD

Am J Gastroenterol 103: 2977-2985; doi:10.1111/j.1572-0241.2008.02174.x

Editorial

Telemetry Capsule for Ambulatory pH Monitoring: Is It Time for a Change?

Philip O Katz MD and Tonantzin Matheus MD

Am J Gastroenterol 103: 2986-2987; doi:10.1111/j.1572-0241.2008.02179.x

Esophagus

Removable Self-Expanding Plastic Esophageal Stent as a Continuous, Non-Permanent Dilator in Treating Refractory Benign Esophageal Strictures: A Prospective Two-Center Study

Kulwinder S Dua MD, FRCP, FACP, FASGE, Frank P Vleggaar MD, PhD, Rajesh Santharam MD and Peter D Siersema MD, PhD

Am J Gastroenterol 103: 2988-2994; doi:10.1111/j.1572-0241.2008.02177.x

Editorial

Refractory Benign Esophageal Strictures: Extending the Role of Expandable Stents

Krish Ragunath MD, FRCP

Am J Gastroenterol 103: 2995-2996; doi:10.1111/j.1572-0241.2008.02178.x

Esophagus

Iron Intake and Body Iron Stores as Risk Factors for Barrett's Esophagus: A Community-Based Study

Douglas A Corley MD, PhD, Ai Kubo PhD, Theodore R Levin MD, Laurel Habel PhD, Wei Zhao MPH, Patricia Leighton MA, Gregory Rumore MD, Charles Quesenberry PhD, Patricia Buffler PhD and Gladys Block PhD

Am J Gastroenterol 103: 2997-3004; doi:10.1111/j.1572-0241.2008.02156.x

Stomach

Helicobacter Pylori Infection Is Significantly Associated With Metabolic Syndrome in the Japanese Population

Toshiaki Gunji MD, Nobuyuki Matsuhashi MD, Hajime Sato PhD, Kazutoshi Fujibayashi MD, Mitsue Okumura MD, Noriko Sasabe MD and Akio Urabe MD

Am J Gastroenterol 103: 3005-3010; doi:10.1111/j.1572-0241.2008.02151.x

Endoscopy

High- Versus Low-Dose Proton Pump Inhibitors After Endoscopic Hemostasis in Patients With Peptic Ulcer Bleeding: A Multicentre, Randomized Study

Angelo Andriulli MD, Silvano Loperfido MD, Rosaria Focareta MD, Pietro Leo MD, Fabio Fornari MD, Antonietta Garripoli MD, Paolo Tonti MD, Sergio Peyre MD, Antonio Spadaccini MD, Riccardo Marmo MD, Antonio Merla MD, Alessandro Caroli MD, Gian Battista Forte MD, Angelo Belmonte MD, Giovanni Aragona MD, Gianni Imperiali MD, Fabrizio Forte MD, Fabio Monica MD, Nazario Caruso MD and Francesco Perri MD

Am J Gastroenterol 103: 3011-3018; doi:10.1111/j.1572-0241.2008.02149.x

Editorial

The Infusion Illusion

Laura E Targownik MD, MSHS and Peter A Thomson BSc(Pharm), PharmD

Am J Gastroenterol 103: 3019-3021; doi:10.1111/j.1572-0241.2008.02164.x

Endoscopy

Capsule Endoscopy's Impact on Clinical Management and Outcomes: A Single-Center Experience With 145 Patients

Elaine Toy MD, Micha Rojany MD, Rafiq Sheikh MD, Surinder Mann MD and Thomas Prindiville MD

Am J Gastroenterol 103: 3022-3028; doi:10.1111/j.1572-0241.2008.02154.x

Liver and Biliary Tract

Hepatic Steatosis and Subclinical Cardiovascular Disease in a Cohort Enriched for Type 2 Diabetes: The Diabetes Heart Study

Ryan L McKimmie MD, Kurt R Daniel DO, MS, J Jeffrey Carr MD, MS, Donald W Bowden PhD, Barry I Freedman MD, Thomas C Register PhD, Fang-Chi Hsu PhD, Kurt K Lohman MS, Richard B Weinberg MD and Lynne E Wagenknecht PhD

Am J Gastroenterol 103: 3029-3035; doi:10.1111/j.1572-0241.2008.02188.x

Editorial

Association Between Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease: A First Message Should Pass

Antonio Picardi MD, PhD and Umberto Vespasiani-Gentilucci MD

Am J Gastroenterol 103: 3036-3038; doi:10.1111/j.1572-0241.2008.02196.x

Liver and Biliary Tract

Cytokine Gene Polymorphisms in Heavy Drinkers With and Without Decompensated Liver Disease: A Case-Control Study

Dermot Gleeson BSc, MD, FRCP, Martin P Bradley RGN, MPH, Jayne Jones RGN, Robert J Peck FRCR, Sarah K Bond BSc(hons), M. Dawn Teare PhD and Gordon W Duff MD, PhD

Am J Gastroenterol 103: 3039-3046; doi:10.1111/j.1572-0241.2008.02150.x

Cannabinoids and Capsaicin Improve Liver Function Following Thioacetamide-Induced Acute Injury in Mice

Yosefa Avraham PhD, Olga Zolotarev MD, Nikolaos C Grigoriadis MD, PhD, Theofilos Pautahidis PhD, Iddo Magen MSc, Lia Vorobiav PhD, Andreas Zimmer PhD, Yaron Ilan MD, Raphael Mechoulam PhD and Elliot M Berry MD, FRCP

Am J Gastroenterol 103: 3047-3056; doi:10.1111/j.1572-0241.2008.02155.x

Neoplastic Seeding After Radiofrequency Ablation for Hepatocellular Carcinoma

Jun Imamura MD, PhD, Ryosuke Tateishi MD, PhD, Shuichiro Shiina MD, PhD, Eriko Goto MD, Takahisa Sato MD, Takamasa Ohki MD, PhD, Ryota Masuzaki MD, PhD, Tadashi Goto MD, PhD, Hideo Yoshida MD, PhD, Fumihiko Kanai MD, PhD, Keisuke Hamamura MD, PhD, Shuntaro Obi MD, PhD, Haruhiko Yoshida MD, PhD and Masao Omata MD, PhD

Am J Gastroenterol 103: 3057-3062; doi:10.1111/j.1572-0241.2008.02153.x

Mycophenolate Mofetil as Second Line Therapy in Autoimmune Hepatitis?

Elke M Hennes MD, Ye H Oo MD, Christoph Schramm MD, Ulrike Denzer MD, Peter Buggisch MD, Christiane Wiegard MD, Stephan Kanzler MD, Marcus Schuchmann MD, Wulf Boecher MD, Peter R Galle MD, David H Adams MD and Ansgar W Lohse MD

Am J Gastroenterol 103: 3063-3070; doi:10.1111/j.1572-0241.2008.02180.x

Evaluation of Alanine Transaminase and Hepatitis B Virus DNA to Predict Liver Cirrhosis in Hepatitis B e Antigen-Negative Chronic Hepatitis B Using Transient Elastography

Grace Lai-Hung Wong MBChB, Vincent Wai-Sun Wong MBChB, Paul Cheung-Lung Choi MBChB, Anthony Wing-Hung Chan MBChB, Angel Mei-Ling Chim MSc, Karen Ka-Lam Yiu BA, Hoi-Yun Chan MPhil, Francis Ka-Leung Chan MD, Joseph Jao-Yao Sung MD, PhD and Henry Lik-Yuen Chan MD

Am J Gastroenterol 103: 3071-3081; doi:10.1111/j.1572-0241.2008.02157.x

IBD

Perianal Disease Predicts Changes in Crohn's Disease Phenotype—Results of a Population-Based Study of Inflammatory Bowel Disease Phenotype

Kelly M Tarrant B.BiomedSc, Murray L Barclay MB, ChB, MD, FRACP, Christopher M A Frampton PhD and Richard B Gearry MB, ChB, PhD, FRACP

Am J Gastroenterol 103: 3082-3093; doi:10.1111/j.1572-0241.2008.02212.x

Cost-Effectiveness of 5-Aminosalicylic Acid Therapy for Maintenance of Remission in Ulcerative Colitis

Eugene F Yen MD, Sunanda V Kane MD, MSPH and Uri Ladabaum MD, MS

Am J Gastroenterol 103: 3094-3105; doi:10.1111/j.1572-0241.2008.02130.x

Mesalamine Foam Enema Versus Mesalamine Liquid Enema in Active Left-Sided Ulcerative Colitis

Antoine Cortot MD, Denis Maetz MD, Eric Degoutte MD, Olivier Delette MD, Pierre Meunier MD, Gie Tan MD, Jean-Brice Cazals MD, Olivier Dewit MD, Xavier Hebuterne MD, Sylvain Beorchia MD, Bernard Grunberg MD, Eric Leprince MD, Geert D'Haens MD, Sylvie Forestier MD, Isabelle Idier MD and Marc Lémann MD

Am J Gastroenterol 103: 3106-3114; doi:10.1111/j.1572-0241.2008.02152.x

A 6-Thioguanine Nucleotide Threshold Level of 400 pmol/8 times 108 Erythrocytes Predicts Azathioprine Refractoriness in Patients With Inflammatory Bowel Disease and Normal TPMT Activity

Xavier Roblin MD, Laurent P Biroulet MD, PhD, Jean M Phelip MD, PhD, Stéphane Nancey MD, PhD and Bernard Flourie MD

Am J Gastroenterol 103: 3115-3122; doi:10.1111/j.1572-0241.2008.01743.x

Defining the Optimal Response Criteria for the Crohn's Disease Activity Index for Induction Studies in Patients With Mildly to Moderately Active Crohn's Disease

Kelvin T Thia MBBS, William J Sandborn MD, James D Lewis MD, Edward V Loftus, Jr MD, Brian G Feagan MD, A Hillary Steinhart MD, Stephen B Hanauer MD, Tore Persson PhD and Bruce E Sands MD

Am J Gastroenterol 103: 3123-3131; doi:10.1111/j.1572-0241.2008.02176.x

Effects of Adalimumab Maintenance Therapy on Health-Related Quality of Life of Patients With Crohn's Disease: Patient-Reported Outcomes of the CHARM Trial

Edward V Loftus MD, Brian G Feagan MD, Jean-Frédéric Colombel MD, David T Rubin MD, Eric Q Wu PhD, Andrew P Yu PhD, Paul F Pollack MD, Jingdong Chao PhD and Parvez Mulani Phd

Am J Gastroenterol 103: 3132-3141; doi:10.1111/j.1572-0241.2008.02175.x

Colon/Small Bowel

Rates of New or Missed Colorectal Cancer After Barium Enema and Their Risk Factors: A Population-Based Study

Jonathan Toma BSc, Lawrence F Paszat MD, MS, Nadia Gunraj BSc, MPH and Linda Rabeneck MD, MPH

Am J Gastroenterol 103: 3142-3148; doi:10.1111/j.1572-0241.2008.02199.x

Editorial

Considering Double Contrast Barium Enema and Its Demise: A Case for Systematic Videorecording of Colonoscopy

Douglas K Rex MD, FACG

Am J Gastroenterol 103: 3149-3151; doi:10.1111/j.1572-0241.2008.02206.x

Pathology

The Presence of Small Intestinal Intraepithelial Gamma/Delta T-Lymphocytes Is Inversely Correlated With Lymphoma Development in Refractory Celiac Disease

Wieke H M Verbeek MD, B Mary E von Blomberg PhD, Petra E T Scholten BSc, D Joop Kuik MSc, Chris J J Mulder MD PhD and Marco W J Schreurs PhD

Am J Gastroenterol 103: 3152-3158; doi:10.1111/j.1572-0241.2008.02213.x

NUTRITION/OBESITY

The Impact of Diet on Liver Fibrosis and on Response to Interferon Therapy in Patients With HCV-Related Chronic Hepatitis

Carmela Loguercio MD, Alessandro Federico MD, Mario Masarone MD, Roberto Torella MD, Camillo Del Vecchio Blanco MD and Marcello Persico MD

Am J Gastroenterol 103: 3159-3166; doi:10.1111/j.1572-0241.2008.02159.x

Top

Clinical Reviews

An Update on the Epidemiology of Inflammatory Bowel Disease in Asia

Kelvin T Thia MBBS, Edward V Loftus Jr MD, William J Sandborn MD and Suk-Kyun Yang MD

Am J Gastroenterol 103: 3167-3182; doi:10.1111/j.1572-0241.2008.02158.x

Continuing Medical Education: December 2008

Am J Gastroenterol 103: 3183; doi:10.1111/j.1572-0241.2008.02223.x

Gastrointestinal and Hepatic Manifestations of Sarcoidosis

Ellen C Ebert MD, Malca Kierson DO and Klaus D Hagspiel MD

Am J Gastroenterol 103: 3184-3192; doi:10.1111/j.1572-0241.2008.02202.x

Continuing Medical Education Questions: December 2008

James S Scolapio MD CME Editor, Anna M Buchner MD CME Author, Muhammad K Hasan MD CME Author and Kanwar R S Gill MD CME Author

Am J Gastroenterol 103: 3193; doi:10.1111/j.1572-0241.2008.02224.x

Continuing Medical Education: December 2008

Am J Gastroenterol 103: 3194; doi:10.1111/j.1572-0241.2008.02225.x

Clinical Review of the Management of Fulminant Clostridium difficile Infection

M Raffat Jaber MD, Snorri Olafsson MD, PhD, MPH, Wesley L Fung MD and Mark E Reeves MD, PhD

Am J Gastroenterol 103: 3195-3203; doi:10.1111/j.1572-0241.2008.02198.x

Continuing Medical Education Questions: December 2008

James S Scolapio MD CME Editor, Benjamin Levitzky MD CME Author, Frank Marrero MD CME Author and Mohammed Qadeer MD CME Author

Am J Gastroenterol 103: 3204; doi:10.1111/j.1572-0241.2008.02226.x

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Letters to the Editor

Columnar-lined Esophagus without Intestinal Metaplasia should not be Dismissed as having no Cancer Risk

Clive Kelty MBChB, PhD, FRCSEd, FRCS (Gen Surg)

Am J Gastroenterol 103: 3205; doi:10.1111/j.1572-0241.2008.02161_1.x

Response to Dr. Kelty et al.

Kenneth K Wang MD and Richard E Sampliner MD

Am J Gastroenterol 103: 3205-3206; doi:10.1111/j.1572-0241.2008.02161_2.x

Clinicians and FDA Decisions

Jerry Gardner MD

Am J Gastroenterol 103: 3206; doi:10.1111/j.1572-0241.2008.02161_3.x

Response to Dr. Gardner

Lawrence J Brandt MD, MACG

Am J Gastroenterol 103: 3206; doi:10.1111/j.1572-0241.2008.02161_4.x

Reply to Letter from Dr. Jerry Gardner about: Balancing Drug Risk and Benefit: Toward Refining the Process of FDA Decisions Affecting Patient Care

Lawrence R Schiller MD, FACG and David A Johnson MD, FACG

Am J Gastroenterol 103: 3207; doi:10.1111/j.1572-0241.2008.02161_5.x

Statins and Hepatitis C Virus: More Caution And Less Enthusiasm

Mark R Goldstein MD, FACP, Luca Mascitelli MD and Francesca Pezzetta MD

Am J Gastroenterol 103: 3207-3208; doi:10.1111/j.1572-0241.2008.02161_6.x

Reply to Dr Goldstein about HCV and Fluvastatin: Less Armchair and More Science

Ted Bader MD

Am J Gastroenterol 103: 3208-3209; doi:10.1111/j.1572-0241.2008.02161_7.x

Endoscopic-guided versus Cotton-tipped Applicator Methods of Nasal Anesthesia for Transnasal Esophagogastroduodenoscopy

Massimo Maffei MD and Jean-Marc Dumonceau MD, PhD

Am J Gastroenterol 103: 3209; doi:10.1111/j.1572-0241.2008.02161_8.x

Response to Dr. Dumonceau et al.

Chi-Tan Hu MD, PhD

Am J Gastroenterol 103: 3209-3210; doi:10.1111/j.1572-0241.2008.02161_9.x

Diagnostic Problems in the Evaluation of Colorectal Adenomas

Vincenzo Villanacci MD

Am J Gastroenterol 103: 3210-3211; doi:10.1111/j.1572-0241.2008.02161_10.x

"Should High Grade Dysplasia or Degree of Villous Change in Colonic Polyps be Reported?" Previously Reported in American Journal of Gastroenterology, Reply to Dr. Villanacci

Robert D Odze MD, FRCP (C)

Am J Gastroenterol 103: 3211-3212; doi:10.1111/j.1572-0241.2008.02161_11.x

Cotton Pledget Method for Nasal Decongestive Anesthesia Prior to Transnasal Endoscopy

Yi-Chia Lee MD and Cheng-Ping Wang MD

Am J Gastroenterol 103: 3212-3213; doi:10.1111/j.1572-0241.2008.02161_12.x

Mycophenolate Sodium: Effective Treatment for Therapy-Refractory Intestinal Behçet's Disease, Evaluated With Enteroscopy

Jasper H Kappen MSc, Peter B F Mensink MD, PhD, Wilco Lesterhuis MD, PhD, Sangeeta Lachman BSc, Paul L A van Daele MD, PhD, P Martin van Hagen MD, PhD and Jan A M van Laar MD, PhD

Am J Gastroenterol 103: 3213-3214; doi:10.1111/j.1572-0241.2008.02161_13.x

alpha-Defensins and Clostridium difficile Recent Growing Concerns in Inflammatory Bowel Disease

Guillaume Savoye MD, PhD

Am J Gastroenterol 103: 3215; doi:10.1111/j.1572-0241.2008.02161_14.x

Stent-In-Stent Insertion Using Argon Plasma Coagulation for the Cannulation of Multiple Malfunctioning Biliary Noncovered Self-Expandable Metal Stents

Dimitri Coumaros MD and Niki Tsesmeli MD

Am J Gastroenterol 103: 3215-3217; doi:10.1111/j.1572-0241.2008.02161_15.x

Comments regarding "Consensus Recommendations for Gastric Emptying Scintigraphy"

Martin L Nusynowitz MD

Am J Gastroenterol 103: 3217; doi:10.1111/j.1572-0241.2008.02161_16.x

Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

Teoman Dogru MD, Cemal Nuri Ercin MD, Gokhan Erdem MD, Alper Sonmez MD, Serkan Tapan MD and Ilker Tasci MD

Am J Gastroenterol 103: 3217-3218; doi:10.1111/j.1572-0241.2008.02161_17.x

"Short" Double-Balloon Enteroscope for Diagnostic and Therapeutic ERCP in Patients With Altered Gastrointestinal Anatomy

Mitsunobu Matsushita MD, Masaaki Shimatani MD, Makoto Takaoka MD and Kazuichi Okazaki MD

Am J Gastroenterol 103: 3218-3219; doi:10.1111/j.1572-0241.2008.02161_18.x

Prognosis and Therapy of Wernicke's Encephalopathy After Obesity Surgery

GianPietro Sechi MD

Am J Gastroenterol 103: 3219; doi:10.1111/j.1572-0241.2008.02161_19.x

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Announcement

Calendar of Courses, Symposiums, and Conferences

Am J Gastroenterol 103: 3220-3221; doi:10.1111/j.1572-0241.2008.02222.x

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Index

Author Index

Am J Gastroenterol 103: 3222-3233; doi:10.1111/j.1572-0241.2008.auindex_1.x

Subject Index

Am J Gastroenterol 103: 3234-3244; doi:10.1111/j.1572-0241.2008.suindex_1.x

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