Original Contribution

The American Journal of Gastroenterology (2005) 100, 1558–1559; doi:10.1111/j.1572-0241.2005.50009.x

IgG-Mediated Food Intolerance in Irritable Bowel Syndrome: A Real Phenomenon or an Epiphenomenom?

Fergus Shanahan MD1 and Peter J. Whorwell MD2

  1. 1Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland,
  2. 2Department of Medicine, Education & Research Centre, Wythenshawe Hospital, Manchester, UK

Correspondence: PJ Whorwell, Education & Research Centre, Wythenshawe Hospital Manchester M23 9LT, UK

Received 4 January 2005; Revised  0000; Accepted 18 January 2005.



Abnormal reactions to food probably contribute to the complex pathophysiology of irritable bowel syndrome, but the mechanisms involved remain unclear. Following the recent identification of subtle mucosal inflammation in at least some patients with the disorder, perhaps now is the time to revisit some of the immunological reactions to dietary antigens that, in the past, have been dismissed as irrelevant.