TABLE 2
FROM:
The Effect of HIV Coinfection on the Risk of Cirrhosis and Hepatocellular Carcinoma in U.S. Veterans with Hepatitis C
Jennifer R Kramer, Thomas P Giordano, Julianne Souchek, Peter Richardson, Lu-Yu Hwang and Hashem B El-Serag
BACK TO ARTICLETable 2. Incidence Rates, Incidence Rate Ratios, and Adjusted Hazard Ratios of Cirrhosis and Hepatocellular Carcinoma in 26,641 HCV-Only and 4,761 HIV Coinfected Veterans
| HIV and HCV Coinfection | HCV-Only | HCV–HIV Coinfection vs HCV-Only | ||||
|---|---|---|---|---|---|---|
| Outcome Event | Number of Events | Incidence Rate Per 1,000 Person-Years | Number of Events | Incidence Rate Per 1,000 Person-Years | Incidence Rate Ratio (95% CI) | Adjusted Hazard Ratio‡ (95% CI) |
| Cirrhosis, entire cohort | 318 | 15.9 | 2,096 | 19.7 | 0.81 (0.72–0.91) | 0.99 (0.87–1.12) |
| Cirrhosis, pre-HAART era† | 48 | 10.8 | 231 | 10.1 | 1.07 (0.76–1.46) | 1.48 (1.06–2.07)* |
| Cirrhosis, HAART era | 111 | 20.7 | 788 | 22.4 | 0.92 (0.75–1.13) | 1.15 (0.93–1.41) |
| HCC, entire cohort | 27 | 1.3 | 221 | 2.0 | 0.67 (0.43–0.99) | 0.84 (0.55–1.27) |
| HCC, HAART era | 12 | 2.2 | 76 | 2.1 | 1.04 (0.51–1.92) | 1.21 (0.64–2.28) |
HCV = hepatitis C virus; CI = confidence interval; HAART = highly active antiretroviral therapy; HCC = hepatocellular carcinoma.
* p-value = 0.0216, all other p-values >0.05
† Patients with an index hospitalization before October 1, 1996 with follow-up right censored; therefore, outcomes developing during the HAART era in these patients were not counted.
‡ Adjusted hazard ratios derived from separate multivariate Cox proportional hazards models. Cirrhosis models adjusted for age, race, sex, toxic hepatitis, coagulation disorder, chronic HBV, diabetes mellitus, drug dependence, and alcoholism. HCC models adjusted for age, race, sex, chronic HBV, diabetes, coagulation disorder, drug dependence, and alcoholism.
HCC for pre-HAART era not shown due to small number of cases.
