Aim:

To investigate the pathological features of the prostate biopsy through mass screening for prostate cancer in a Chinese cohort and their association with serum prostate specific antigen (PSA).

Methods:

A total of 12 027 Chinese men in Changchun were screened for prostate cancer by means of the serum total prostate specific antigen (tPSA) test (by Elisa assay). Transrectal ultrasound-guided systematic six-sextant biopsies were performed on those whose serum tPSA value was >4.0 ng/mL and those who had obstructive symptoms (despite their tPSA value) and were subject to subsequent pathological analysis with the aid of the statistic software SPSS 10.0 (SPSS. Inc., Chicago. USA).

Results:

Of the 12 027 cases, 158 (including 137 patients whose serum tPSA values were >4.0 ng/mL and 21 patients [serum tPSA <4.0 ng/mL] who had obstructive symptoms) undertook prostate biopsy. Of the 158 biopsies, 41 cases of prostatic carcinoma were found (25.9 %, 41/158). The moderately differentiated carcinoma and poorly differentiated carcinoma accounted for 61 % and 34 %, respectively. A significant linear positive correlation between the serum tPSA and the Gleason scores in the 41 cases of prostatic carcinoma (r= 0.312, P < 0.01) was established. A significant linear positive correlation between the serum tPSA value of the 41 prostatic carcinoma and the positive counts of carcinoma in sextant biopsies was established (r= 0.406, P < 0.01), indicating a significant linear relationship between serum tPSA and the size of tumor.

Conclusion:

This study was the first to conduct mass screening for prostate cancer by testing for serum tPSA values and the first to investigate the pathological features of prostate cancer in a cohort of Chinese men. Our results reveal that the moderately differentiated carcinoma is the most common type of prostate cancer. This study also has shown that the serum tPSA value in prostate cancer is associated with the Gleason score and the size of tumor.

References

1. Humphrey PA, Vollmer RT. Relationships between serum prostate-specific antigen and histopathologic appearances of prostate carcinoma. In: Foster CS, Bostwick DG, editors. Pathology of Prostate. London: W. B. Saunders Company; 1998. p 253–81.
2. Harada M, Nemoto R, Uchida K, Akaza H, Koiso K, Mostofi FK. Histopathological comparison of prostatic adenocarcinoma in Japan and the United States. Nippon Hinyokika Gakkai Zasshi 1993; 84: 1110–18. | PubMed | ChemPort |
3. Humphrey PA, Keetch DW, Smith DS, Shepherd DL, Catalona WJ. Prospective characterization of pathological features of prostatic carcinomas detected via serum prostate specific antigen based screening. J Urol 1996; 155: 816–20. | Article | PubMed | ISI | ChemPort |
4. Bostick DG, Dundore P. Biopsy Pathology of the Prostate. New York: Chapman & Hall Medical; 1997. p 141–63.
5. Rigley JR, Bullock M, Amin M. Small glandular patterns in the prostate: differential diagnosis of small acinar carcinoma. In: Foster CS, Bostwick DG, editors. Pathology of Prostate. London: W. B. Saunders Company; 1998. p 126–55.
6. Shirley SE, Escoffery CT, Sargeant LA, Tulloch T. Clinico-pathological features of prostate cancer in Jamaican men. BJU 2002; 89: 390–5. | Article | ChemPort |
7. Catalona WJ, Richie JP, Ahmann FR, Hudson MA, Scardino PT, Flanigan RC, et al. Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6, 630 men. J Urol 1994; 151: 1283–90. | PubMed | ISI | ChemPort |
8. Hoedemaeker RF, van der Kwast TH, Boer R, de Koning HJ, Roobol M, Vis AN, et al. Pathologic features of prostate cancer found at population-based screening with a four-year interval. J Natl Cancer Inst 2001; 93: 1153–8. | Article | PubMed | ChemPort |

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