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Volume 561 Issue 7723

Latest Research

  • Letter |

    A reinforcement learning approach allows a suitably equipped glider to navigate thermal plumes autonomously in an open field.

    • Gautam Reddy
    • , Jerome Wong-Ng
    • , Antonio Celani
    • , Terrence J. Sejnowski
    •  & Massimo Vergassola

  • Letter |

    The diversity in the hydraulic traits of trees mediates ecosystem resilience to drought and will probably have an important role in future ecosystem–atmosphere feedback effects.

    • William R. L. Anderegg
    • , Alexandra G. Konings
    • , Anna T. Trugman
    • , Kailiang Yu
    • , David R. Bowling
    • , Robert Gabbitas
    • , Daniel S. Karp
    • , Stephen Pacala
    • , John S. Sperry
    • , Benjamin N. Sulman
    •  & Nicole Zenes

  • Article |

    The detection of hypocretin-specific autoreactive CD4+ and CD8+ T cells in patients with narcolepsy reveals the autoimmune aetiology of this disorder.

    • Daniela Latorre
    • , Ulf Kallweit
    • , Eric Armentani
    • , Mathilde Foglierini
    • , Federico Mele
    • , Antonino Cassotta
    • , Sandra Jovic
    • , David Jarrossay
    • , Johannes Mathis
    • , Francesco Zellini
    • , Burkhard Becher
    • , Antonio Lanzavecchia
    • , Ramin Khatami
    • , Mauro Manconi
    • , Mehdi Tafti
    • , Claudio L. Bassetti
    •  & Federica Sallusto

  • Article |

    A high-resolution cryo-electron microscopy structure of a complete Tc holotoxin complex reveals the precise mechanism of Tc toxin assembly, gate opening and release of the cytotoxic enzyme into the translocation channel.

    • Christos Gatsogiannis
    • , Felipe Merino
    • , Daniel Roderer
    • , David Balchin
    • , Evelyn Schubert
    • , Anne Kuhlee
    • , Manajit Hayer-Hartl
    •  & Stefan Raunser

  • Letter |

    The absolute timing of the photoelectric effect has proved difficult to measure, but the delay between photon arrival at a tungsten surface and ejection of photoelectrons has now been determined.

    • M. Ossiander
    • , J. Riemensberger
    • , S. Neppl
    • , M. Mittermair
    • , M. Schäffer
    • , A. Duensing
    • , M. S. Wagner
    • , R. Heider
    • , M. Wurzer
    • , M. Gerl
    • , M. Schnitzenbaumer
    • , J. V. Barth
    • , F. Libisch
    • , C. Lemell
    • , J. Burgdörfer
    • , P. Feulner
    •  & R. Kienberger

  • Letter |

    • Yang Liu
    • , Qi Zhao
    • , Ming-Han Li
    • , Jian-Yu Guan
    • , Yanbao Zhang
    • , Bing Bai
    • , Weijun Zhang
    • , Wen-Zhao Liu
    • , Cheng Wu
    • , Xiao Yuan
    • , Hao Li
    • , W. J. Munro
    • , Zhen Wang
    • , Lixing You
    • , Jun Zhang
    • , Xiongfeng Ma
    • , Jingyun Fan
    • , Qiang Zhang
    •  & Jian-Wei Pan

  • Letter |

    An analysis of the motions of six million stars in the Milky Way disk reveals substructures such as snail shells and ridges, indicating that our Galaxy has been recently perturbed.

    • T. Antoja
    • , A. Helmi
    • , M. Romero-Gómez
    • , D. Katz
    • , C. Babusiaux
    • , R. Drimmel
    • , D. W. Evans
    • , F. Figueras
    • , E. Poggio
    • , C. Reylé
    • , A. C. Robin
    • , G. Seabroke
    •  & C. Soubiran
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Latest Reviews & Analysis

  • News & Views |

    Aggregation of the protein tau is implicated in neurodegenerative diseases in humans. It emerges that eliminating a type of damaged cell that no longer divides can prevent tau-mediated neurodegeneration in mice.

    • Jay Penney
    •  & Li-Huei Tsai

  • News & Views |

    Chromosomes can exist outside the nucleus in rupture-prone structures called micronuclei. It emerges that micronuclei are fragile because their outer layer lacks some nuclear-envelope components.

    • Matthias Samwer
    •  & Daniel W. Gerlich

  • News & Views |

    Photoemission, the ejection of an electron from a material on the absorption of a photon, is one of the fastest processes in nature. An experiment demonstrates how the dynamics of this process can be captured in real time.

    • Thomas Fennel

  • News & Views |

    The sleep disorder narcolepsy is linked to immune-system genes and is caused by the loss of neurons that express the protein hypocretin. Hypocretin-targeting immune cells have now been found in people with narcolepsy.

    • Roland S. Liblau

  • News & Views |

    Experiments show that short bunches of protons can produce electric fields that are strong enough to accelerate energetic electrons compactly. This discovery could lead to miniaturized high-energy particle accelerators.

    • Toshiki Tajima

  • News & Views |

    What Nature was saying 50 and 100 years ago.

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News & Comment

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Journal tools

Nature Outlook

Alzheimer’s disease

Giulio Bonasera

Alzheimer’s disease

Alzheimer’s disease is the most common form of dementia. For decades, researchers have sought a treatment to no avail, and our understanding of the condition is now being questioned.
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