Latest Research

  • Letter |

    The carboxy terminus of human UDP-α-d-glucose-6-dehydrogenase is structurally disordered, but has sequence-independent effects on the conformation of the enzyme and binding of an allosteric inhibitor, suggesting a reason for the persistence of intrinsically disordered peptide segments in the proteome.

    • Nicholas D. Keul
    • , Krishnadev Oruganty
    • , Elizabeth T. Schaper Bergman
    • , Nathaniel R. Beattie
    • , Weston E. McDonald
    • , Renuka Kadirvelraj
    • , Michael L. Gross
    • , Robert S. Phillips
    • , Stephen C. Harvey
    •  & Zachary A. Wood
  • Letter |

    Uranium-series dating of rock art from Borneo reveals a minimum date for figurative artwork of 40,000 years ago, and a distinct style of parietal art in Southeast Asia at the Last Glacial Maximum.\

    • M. Aubert
    • , P. Setiawan
    • , A. A. Oktaviana
    • , A. Brumm
    • , P. H. Sulistyarto
    • , E. W. Saptomo
    • , B. Istiawan
    • , T. A. Ma’rifat
    • , V. N. Wahyuono
    • , F. T. Atmoko
    • , J.-X. Zhao
    • , J. Huntley
    • , P. S. C. Taçon
    • , D. L. Howard
    •  & H. E. A. Brand
  • Letter |

    Cryo-electron microscopy structures of the ABCG2 protein in ATP- and substrate-bound states reveal the location of substrate binding, conformational changes required for substrate translocation and how inhibitors might be distinguished from substrates.

    • Ioannis Manolaridis
    • , Scott M. Jackson
    • , Nicholas M. I. Taylor
    • , Julia Kowal
    • , Henning Stahlberg
    •  & Kaspar P. Locher
  • Letter |

    A small-molecule agonist for the cGAS–STING pathway has systemic activity in a mouse model of colon cancer.

    • Joshi M. Ramanjulu
    • , G. Scott Pesiridis
    • , Jingsong Yang
    • , Nestor Concha
    • , Robert Singhaus
    • , Shu-Yun Zhang
    • , Jean-Luc Tran
    • , Patrick Moore
    • , Stephanie Lehmann
    • , H. Christian Eberl
    • , Marcel Muelbaier
    • , Jessica L. Schneck
    • , Jim Clemens
    • , Michael Adam
    • , John Mehlmann
    • , Joseph Romano
    • , Angel Morales
    • , James Kang
    • , Lara Leister
    • , Todd L. Graybill
    • , Adam K. Charnley
    • , Guosen Ye
    • , Neysa Nevins
    • , Kamelia Behnia
    • , Amaya I. Wolf
    • , Viera Kasparcova
    • , Kelvin Nurse
    • , Liping Wang
    • , Yue Li
    • , Michael Klein
    • , Christopher B. Hopson
    • , Jeffrey Guss
    • , Marcus Bantscheff
    • , Giovanna Bergamini
    • , Michael A. Reilly
    • , Yiqian Lian
    • , Kevin J. Duffy
    • , Jerry Adams
    • , Kevin P. Foley
    • , Peter J. Gough
    • , Robert W. Marquis
    • , James Smothers
    • , Axel Hoos
    •  & John Bertin
  • Letter |

    Cooperative quantum effects in superlattices of quantum dots made of caesium lead halide perovskite give rise to superfluorescence, with the individual emitters interacting coherently to give intense bursts of light.

    • Gabriele Rainò
    • , Michael A. Becker
    • , Maryna I. Bodnarchuk
    • , Rainer F. Mahrt
    • , Maksym V. Kovalenko
    •  & Thilo Stöferle
  • Letter |

    High-resolution infrared observations of hard-X-ray-selected black holes show an excess of late-stage mergers in obscured luminous black holes compared with inactive galaxies of similar stellar masses and star formation rates.

    • Michael J. Koss
    • , Laura Blecha
    • , Phillip Bernhard
    • , Chao-Ling Hung
    • , Jessica R. Lu
    • , Benny Trakthenbrot
    • , Ezequiel Treister
    • , Anna Weigel
    • , Lia F. Sartori
    • , Richard Mushotzky
    • , Kevin Schawinski
    • , Claudio Ricci
    • , Sylvain Veilleux
    •  & David B. Sanders
  • Letter |

    Degenerate and thermal Bose gases, quenched so that the interparticle interactions are as strong as allowed by quantum mechanics, exhibit dynamics that can be expressed in terms of universal functions.

    • Christoph Eigen
    • , Jake A. P. Glidden
    • , Raphael Lopes
    • , Eric A. Cornell
    • , Robert P. Smith
    •  & Zoran Hadzibabic

Latest Reviews & Analysis

  • News & Views |

    What Nature said 50 and 100 years ago about record-breaking telescopes and the end of the First World War.

  • News & Views |

    A natural chemical reaction that occurs below the sea floor makes the amino acid tryptophan without biological input. This finding reveals a process that might have helped life on Earth to begin.

    • John A. Baross
  • News & Views |

    Understanding the dynamics of quantum systems far from equilibrium is one of the most pressing issues in physics. Three experiments based on ultracold atomic systems provide a major step forward.

    • Michael Kolodrubetz
  • News & Views |

    What Nature was saying 50 and 100 years ago.

  • News & Views |

    A nanometre-scale mechanism has been proposed to explain how bacteria improve their grip on human cells. The findings have implications for drug discovery, and might inspire biomimetic applications such as adhesives.

    • John R. Dutcher

News & Comment

Nature Outline

Ulcerative colitis

Iris Abols

Ulcerative colitis

Ulcerative colitis is a debilitating and incurable condition. But researchers have found fresh angles of attack, and a host of upcoming treatments raise the prospect of a durable victory against this common form of inflammatory bowel disease.

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