The long non-coding RNA NORAD interacts with proteins involved in DNA replication and repair, and controls the ability of RBMX to form a ribonucleoprotein complex that helps to maintain genomic stability.

Cryo-electron microscopy analysis of the purified Plasmodium translocon of exported proteins (PTEX) reveals two distinct resolved states, suggesting a mechanism by which Plasmodium falciparum exports malarial effector proteins into erythrocytes.

All-inorganic perovskite nanocrystals containing caesium and lead provide low-cost, flexible and solution-processable scintillators that are highly sensitive to X-ray irradiation and emit radioluminescence that is colour-tunable across the visible spectrum.

In Caenorhabditis elegans, starvation early in life suppresses later sex-specific pruning of synapses through lasting changes in monoaminergic signalling.

The inactivation of tumour suppressor genes at the level of mRNA occurs by the generation of truncated proteins in leukaemia.

Integrated analyses of multiple cohorts are used to obtain a better understanding of the immune state of latent infection with Mycobacterium tuberculosis, and factors that mediate and/or predict transitions from latent infection to active disease.

Experimental data from, and mathematical modelling of, colonies of the clonal raider ant Ooceraea biroi demonstrate that increases in group size generate division of labour among similar individuals, increased homeostasis and higher colony fitness.

A counter-intuitive state—known as a topological Anderson insulator—in which strong disorder leads to the formation of topologically protected rather than trivial states is realized in a photonic system.

The Ras-related GTPase RAP2 is a key intracellular signal transducer by which extracellular matrix rigidity controls mechanosensitive cellular activities through YAP and TAZ.

The multiprotein complex PTEX enables malaria-causing parasites to survive inside red blood cells. Studies reveal how PTEX assembles, and identify a function for one of the complex’s proteins, EXP2.

Whole-genome sequencing reveals the duplication of a regulatory region, called an enhancer, of the AR gene in treatment-resistant human prostate cancers. The finding shows the importance of analysing non-protein-coding regions of DNA.

Certain materials contain both electric dipoles and magnetic moments. An experiment demonstrates that these properties can be coupled in previously unrecognized ways, leading to advanced functionality.

Monkeys genetically engineered to lack the gene SIRT6 die a few hours after birth, displaying severe growth defects. This finding reveals a previously unknown role for the SIRT6 protein in primate development.

PINK1 and parkin proteins help to degrade damaged mitochondrial organelles, and abnormalities in these proteins are linked to Parkinson’s disease. Mouse studies reveal that the proteins act to prevent inflammation.

The enzyme RNA polymerase II, which transcribes DNA, pauses early in transcription and awaits signals to continue. High-resolution structures reveal how it is stopped and efficiently restarted.

Health system lacks capacity to respond to attacks that use high-powered modern weapons.

Decision-makers need input from researchers on issues involving science and society.

Working conditions in academic labs encourage abusive supervision. It is time to improve monitoring of and penalties for abuse, says Sherry Moss.

Researchers replicated 62% of social-behaviour findings published in Science and Nature — a result matched almost exactly by a prediction market.

Tom Frieden, former director of the US Centers for Disease Control and Prevention, is charged with forcible touching, sex abuse and harassment.

British Heart Foundation award is one of the largest single grants in medical research.