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Volume 561 Issue 7723

Latest Research

  • Article |

    A method for systematically exploring interactions between the nucleosome and transcription factors identifies five major interaction patterns.

    • Fangjie Zhu
    • , Lucas Farnung
    • , Eevi Kaasinen
    • , Biswajyoti Sahu
    • , Yimeng Yin
    • , Bei Wei
    • , Svetlana O. Dodonova
    • , Kazuhiro R. Nitta
    • , Ekaterina Morgunova
    • , Minna Taipale
    • , Patrick Cramer
    •  & Jussi Taipale

  • Letter |

    A periosteal stem cell specialized in intramembranous bone formation has been identified and was found to be essential for normal bone development and fracture healing.

    • Shawon Debnath
    • , Alisha R. Yallowitz
    • , Jason McCormick
    • , Sarfaraz Lalani
    • , Tuo Zhang
    • , Ren Xu
    • , Na Li
    • , Yifang Liu
    • , Yeon Suk Yang
    • , Mark Eiseman
    • , Jae-Hyuck Shim
    • , Meera Hameed
    • , John H. Healey
    • , Mathias P. Bostrom
    • , Dan Avi Landau
    •  & Matthew B. Greenblatt

  • Letter |

    Chip-scale lithium niobate electro-optic modulators that rapidly convert electrical to optical signals and use CMOS-compatible voltages could prove useful in optical communication networks, microwave photonic systems and photonic computation.

    • Cheng Wang
    • , Mian Zhang
    • , Xi Chen
    • , Maxime Bertrand
    • , Amirhassan Shams-Ansari
    • , Sethumadhavan Chandrasekhar
    • , Peter Winzer
    •  & Marko Lončar

  • Letter |

    A reinforcement learning approach allows a suitably equipped glider to navigate thermal plumes autonomously in an open field.

    • Gautam Reddy
    • , Jerome Wong-Ng
    • , Antonio Celani
    • , Terrence J. Sejnowski
    •  & Massimo Vergassola

  • Letter |

    The diversity in the hydraulic traits of trees mediates ecosystem resilience to drought and will probably have an important role in future ecosystem–atmosphere feedback effects.

    • William R. L. Anderegg
    • , Alexandra G. Konings
    • , Anna T. Trugman
    • , Kailiang Yu
    • , David R. Bowling
    • , Robert Gabbitas
    • , Daniel S. Karp
    • , Stephen Pacala
    • , John S. Sperry
    • , Benjamin N. Sulman
    •  & Nicole Zenes

  • Article |

    The detection of hypocretin-specific autoreactive CD4+ and CD8+ T cells in patients with narcolepsy reveals the autoimmune aetiology of this disorder.

    • Daniela Latorre
    • , Ulf Kallweit
    • , Eric Armentani
    • , Mathilde Foglierini
    • , Federico Mele
    • , Antonino Cassotta
    • , Sandra Jovic
    • , David Jarrossay
    • , Johannes Mathis
    • , Francesco Zellini
    • , Burkhard Becher
    • , Antonio Lanzavecchia
    • , Ramin Khatami
    • , Mauro Manconi
    • , Mehdi Tafti
    • , Claudio L. Bassetti
    •  & Federica Sallusto

  • Article |

    A high-resolution cryo-electron microscopy structure of a complete Tc holotoxin complex reveals the precise mechanism of Tc toxin assembly, gate opening and release of the cytotoxic enzyme into the translocation channel.

    • Christos Gatsogiannis
    • , Felipe Merino
    • , Daniel Roderer
    • , David Balchin
    • , Evelyn Schubert
    • , Anne Kuhlee
    • , Manajit Hayer-Hartl
    •  & Stefan Raunser
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Latest Reviews & Analysis

  • News & Views |

    Aggregation of the protein tau is implicated in neurodegenerative diseases in humans. It emerges that eliminating a type of damaged cell that no longer divides can prevent tau-mediated neurodegeneration in mice.

    • Jay Penney
    •  & Li-Huei Tsai

  • News & Views |

    Chromosomes can exist outside the nucleus in rupture-prone structures called micronuclei. It emerges that micronuclei are fragile because their outer layer lacks some nuclear-envelope components.

    • Matthias Samwer
    •  & Daniel W. Gerlich

  • News & Views |

    Photoemission, the ejection of an electron from a material on the absorption of a photon, is one of the fastest processes in nature. An experiment demonstrates how the dynamics of this process can be captured in real time.

    • Thomas Fennel

  • News & Views |

    The sleep disorder narcolepsy is linked to immune-system genes and is caused by the loss of neurons that express the protein hypocretin. Hypocretin-targeting immune cells have now been found in people with narcolepsy.

    • Roland S. Liblau

  • News & Views |

    Experiments show that short bunches of protons can produce electric fields that are strong enough to accelerate energetic electrons compactly. This discovery could lead to miniaturized high-energy particle accelerators.

    • Toshiki Tajima

  • News & Views |

    What Nature was saying 50 and 100 years ago.

More Reviews & Analysis More Reviews & Analysis

News & Comment

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Journal tools

Nature Outlook

Alzheimer’s disease

Giulio Bonasera

Alzheimer’s disease

Alzheimer’s disease is the most common form of dementia. For decades, researchers have sought a treatment to no avail, and our understanding of the condition is now being questioned.
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