Latest Research

  • Article |

    Transcriptomes of about 70,000 single cells from first-trimester deciduas and placentas reveal subsets of perivascular, stromal and natural killer cells in the decidua, with distinct immunomodulatory profiles that regulate the environment necessary for successful placentation.

    • Roser Vento-Tormo
    • , Mirjana Efremova
    • , Rachel A. Botting
    • , Margherita Y. Turco
    • , Miquel Vento-Tormo
    • , Kerstin B. Meyer
    • , Jong-Eun Park
    • , Emily Stephenson
    • , Krzysztof Polański
    • , Angela Goncalves
    • , Lucy Gardner
    • , Staffan Holmqvist
    • , Johan Henriksson
    • , Angela Zou
    • , Andrew M. Sharkey
    • , Ben Millar
    • , Barbara Innes
    • , Laura Wood
    • , Anna Wilbrey-Clark
    • , Rebecca P. Payne
    • , Martin A. Ivarsson
    • , Steve Lisgo
    • , Andrew Filby
    • , David H. Rowitch
    • , Judith N. Bulmer
    • , Gavin J. Wright
    • , Michael J. T. Stubbington
    • , Muzlifah Haniffa
    • , Ashley Moffett
    •  & Sarah A. Teichmann
  • Letter |

    Ordered oxygen complexes in high-entropy alloys enhance both strength and ductility in these compositionally complex solid solutions.

    • Zhifeng Lei
    • , Xiongjun Liu
    • , Yuan Wu
    • , Hui Wang
    • , Suihe Jiang
    • , Shudao Wang
    • , Xidong Hui
    • , Yidong Wu
    • , Baptiste Gault
    • , Paraskevas Kontis
    • , Dierk Raabe
    • , Lin Gu
    • , Qinghua Zhang
    • , Houwen Chen
    • , Hongtao Wang
    • , Jiabin Liu
    • , Ke An
    • , Qiaoshi Zeng
    • , Tai-Gang Nieh
    •  & Zhaoping Lu
  • Article | | open

    An improved, fully re-annotated Aedes aegypti genome assembly (AaegL5) provides insights into the sex-determining M locus, chemosensory systems that help mosquitoes to hunt humans and loci involved in insecticide resistance and will help to generate intervention strategies to fight this deadly disease vector.

    • Benjamin J. Matthews
    • , Olga Dudchenko
    • , Sarah B. Kingan
    • , Sergey Koren
    • , Igor Antoshechkin
    • , Jacob E. Crawford
    • , William J. Glassford
    • , Margaret Herre
    • , Seth N. Redmond
    • , Noah H. Rose
    • , Gareth D. Weedall
    • , Yang Wu
    • , Sanjit S. Batra
    • , Carlos A. Brito-Sierra
    • , Steven D. Buckingham
    • , Corey L. Campbell
    • , Saki Chan
    • , Eric Cox
    • , Benjamin R. Evans
    • , Thanyalak Fansiri
    • , Igor Filipović
    • , Albin Fontaine
    • , Andrea Gloria-Soria
    • , Richard Hall
    • , Vinita S. Joardar
    • , Andrew K. Jones
    • , Raissa G. G. Kay
    • , Vamsi K. Kodali
    • , Joyce Lee
    • , Gareth J. Lycett
    • , Sara N. Mitchell
    • , Jill Muehling
    • , Michael R. Murphy
    • , Arina D. Omer
    • , Frederick A. Partridge
    • , Paul Peluso
    • , Aviva Presser Aiden
    • , Vidya Ramasamy
    • , Gordana Rašić
    • , Sourav Roy
    • , Karla Saavedra-Rodriguez
    • , Shruti Sharan
    • , Atashi Sharma
    • , Melissa Laird Smith
    • , Joe Turner
    • , Allison M. Weakley
    • , Zhilei Zhao
    • , Omar S. Akbari
    • , William C. Black IV
    • , Han Cao
    • , Alistair C. Darby
    • , Catherine A. Hill
    • , J. Spencer Johnston
    • , Terence D. Murphy
    • , Alexander S. Raikhel
    • , David B. Sattelle
    • , Igor V. Sharakhov
    • , Bradley J. White
    • , Li Zhao
    • , Erez Lieberman Aiden
    • , Richard S. Mann
    • , Louis Lambrechts
    • , Jeffrey R. Powell
    • , Maria V. Sharakhova
    • , Zhijian Tu
    • , Hugh M. Robertson
    • , Carolyn S. McBride
    • , Alex R. Hastie
    • , Jonas Korlach
    • , Daniel E. Neafsey
    • , Adam M. Phillippy
    •  & Leslie B. Vosshall
  • Letter |

    An immunoprecipitation-based protocol is developed to analyse DNA methylation in small quantities of circulating cell-free DNA, and can detect and classify cancers in plasma samples from several tumour types.

    • Shu Yi Shen
    • , Rajat Singhania
    • , Gordon Fehringer
    • , Ankur Chakravarthy
    • , Michael H. A. Roehrl
    • , Dianne Chadwick
    • , Philip C. Zuzarte
    • , Ayelet Borgida
    • , Ting Ting Wang
    • , Tiantian Li
    • , Olena Kis
    • , Zhen Zhao
    • , Anna Spreafico
    • , Tiago da Silva Medina
    • , Yadon Wang
    • , David Roulois
    • , Ilias Ettayebi
    • , Zhuo Chen
    • , Signy Chow
    • , Tracy Murphy
    • , Andrea Arruda
    • , Grainne M. O’Kane
    • , Jessica Liu
    • , Mark Mansour
    • , John D. McPherson
    • , Catherine O’Brien
    • , Natasha Leighl
    • , Philippe L. Bedard
    • , Neil Fleshner
    • , Geoffrey Liu
    • , Mark D. Minden
    • , Steven Gallinger
    • , Anna Goldenberg
    • , Trevor J. Pugh
    • , Michael M. Hoffman
    • , Scott V. Bratman
    • , Rayjean J. Hung
    •  & Daniel D. De Carvalho
  • Letter |

    Introduction of a suicide gene together with a linked cell-division gene to generate a safe-cell system enables the selective elimination of proliferating cells after cell transplantation in mouse models of cell therapy.

    • Qin Liang
    • , Claudio Monetti
    • , Maria V. Shutova
    • , Eric J. Neely
    • , Sabiha Hacibekiroglu
    • , Huijuan Yang
    • , Christopher Kim
    • , Puzheng Zhang
    • , Chengjin Li
    • , Kristina Nagy
    • , Maria Mileikovsky
    • , Istvan Gyongy
    • , Hoon-Ki Sung
    •  & Andras Nagy

Latest Reviews & Analysis

  • News & Views |

    The detection of a low-mass exoplanet on a relatively wide orbit has implications for models of planetary formation and evolution, and could open the door to a new era of exoplanet characterization.

    • Rodrigo F. Díaz
  • News & Views |

    A tectonic plate descending into the Mariana Trench carries sea water deep into Earth’s interior. It seems that much more water enters Earth at this location than was thought — with implications for the global water budget.

    • Donna J. Shillington
  • News & Views |

    RNA sequencing of thousands of single cells located at the interface between mother and fetus in early pregnancy reveals remarkable complexity in the cell types and regulatory networks that support reproduction.

    • Sumati Rajagopalan
    •  & Eric O. Long
  • News & Views |

    Have Neanderthals gained an unfair reputation for having led highly violent lives? A comparison of skulls of Neanderthals and prehistoric humans in Eurasia reveals no evidence of higher levels of trauma in these hominins.

    • Marta Mirazón Lahr

News & Comment

Nature Outline

Ulcerative colitis

Iris Abols

Ulcerative colitis

Ulcerative colitis is a debilitating and incurable condition. But researchers have found fresh angles of attack, and a host of upcoming treatments raise the prospect of a durable victory against this common form of inflammatory bowel disease.

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