Latest Research

  • Letter |

    A global dataset of river longitudinal profiles shows that river profiles become straighter with increasing aridity and numerical modelling suggests that this can be explained by rainfall–runoff regimes in different climate zones.

    • Shiuan-An Chen
    • , Katerina Michaelides
    • , Stuart W. D. Grieve
    •  & Michael Bliss Singer
  • Letter |

    Adoptive transfer of CAR T cells against the fibroblast marker FAP reduces cardiac fibrosis and restores function after cardiac injury in mice, providing proof-of-principle for the development of immunotherapeutic treatments for cardiac disease.

    • Haig Aghajanian
    • , Toru Kimura
    • , Joel G. Rurik
    • , Aidan S. Hancock
    • , Michael S. Leibowitz
    • , Li Li
    • , John Scholler
    • , James Monslow
    • , Albert Lo
    • , Wei Han
    • , Tao Wang
    • , Kenneth Bedi
    • , Michael P. Morley
    • , Ricardo A. Linares Saldana
    • , Nikhita A. Bolar
    • , Kendra McDaid
    • , Charles-Antoine Assenmacher
    • , Cheryl L. Smith
    • , Dagmar Wirth
    • , Carl H. June
    • , Kenneth B. Margulies
    • , Rajan Jain
    • , Ellen Puré
    • , Steven M. Albelda
    •  & Jonathan A. Epstein
  • Letter |

    Mollisonia plenovenatrix, a small predatory arthropod from the Burgess Shale dated to about 508 million years ago, is morphologically close to horseshoe crabs, which suggests chelicerates arose as micropredators early during the Cambrian explosion.

    • Cédric Aria
    •  & Jean-Bernard Caron
  • Letter |

    Radio observations show a bipolar bubble structure of size 140 parsecs by 430 parsecs both above and below the Galactic Centre.

    • I. Heywood
    • , F. Camilo
    • , W. D. Cotton
    • , F. Yusef-Zadeh
    • , T. D. Abbott
    • , R. M. Adam
    • , M. A. Aldera
    • , E. F. Bauermeister
    • , R. S. Booth
    • , A. G. Botha
    • , D. H. Botha
    • , L. R. S. Brederode
    • , Z. B. Brits
    • , S. J. Buchner
    • , J. P. Burger
    • , J. M. Chalmers
    • , T. Cheetham
    • , D. de Villiers
    • , M. A. Dikgale-Mahlakoana
    • , L. J. du Toit
    • , S. W. P. Esterhuyse
    • , B. L. Fanaroff
    • , A. R. Foley
    • , D. J. Fourie
    • , R. R. G. Gamatham
    • , S. Goedhart
    • , S. Gounden
    • , M. J. Hlakola
    • , C. J. Hoek
    • , A. Hokwana
    • , D. M. Horn
    • , J. M. G. Horrell
    • , B. Hugo
    • , A. R. Isaacson
    • , J. L. Jonas
    • , J. D. B. L. Jordaan
    • , A. F. Joubert
    • , G. I. G. Józsa
    • , R. P. M. Julie
    • , F. B. Kapp
    • , J. S. Kenyon
    • , P. P. A. Kotzé
    • , H. Kriel
    • , T. W. Kusel
    • , R. Lehmensiek
    • , D. Liebenberg
    • , A. Loots
    • , R. T. Lord
    • , B. M. Lunsky
    • , P. S. Macfarlane
    • , L. G. Magnus
    • , C. M. Magozore
    • , O. Mahgoub
    • , J. P. L. Main
    • , J. A. Malan
    • , R. D. Malgas
    • , J. R. Manley
    • , M. D. J. Maree
    • , B. Merry
    • , R. Millenaar
    • , N. Mnyandu
    • , I. P. T. Moeng
    • , T. E. Monama
    • , M. C. Mphego
    • , W. S. New
    • , B. Ngcebetsha
    • , N. Oozeer
    • , A. J. Otto
    • , S. S. Passmoor
    • , A. A. Patel
    • , A. Peens-Hough
    • , S. J. Perkins
    • , S. M. Ratcliffe
    • , R. Renil
    • , A. Rust
    • , S. Salie
    • , L. C. Schwardt
    • , M. Serylak
    • , R. Siebrits
    • , S. K. Sirothia
    • , O. M. Smirnov
    • , L. Sofeya
    • , P. S. Swart
    • , C. Tasse
    • , D. T. Taylor
    • , I. P. Theron
    • , K. Thorat
    • , A. J. Tiplady
    • , S. Tshongweni
    • , T. J. van Balla
    • , A. van der Byl
    • , C. van der Merwe
    • , C. L. van Dyk
    • , R. Van Rooyen
    • , V. Van Tonder
    • , R. Van Wyk
    • , B. H. Wallace
    • , M. G. Welz
    •  & L. P. Williams
  • Letter |

    The RNA helicase DDX3X has a critical role in regulating both the induction of stress granules and the activation of the NLRP3 inflammasome in cells under stress conditions.

    • Parimal Samir
    • , Sannula Kesavardhana
    • , Deanna M. Patmore
    • , Sebastien Gingras
    • , R. K. Subbarao Malireddi
    • , Rajendra Karki
    • , Clifford S. Guy
    • , Benoit Briard
    • , David E. Place
    • , Anannya Bhattacharya
    • , Bhesh Raj Sharma
    • , Amanda Nourse
    • , Sharon V. King
    • , Aaron Pitre
    • , Amanda R. Burton
    • , Stephane Pelletier
    • , Richard J. Gilbertson
    •  & Thirumala-Devi Kanneganti
  • Letter |

    Galaxy GSN 069 has unprecedented eruptions of X-ray light every nine hours, which indicate fast transitions between cold and warm states and may shed light on black hole accretion.

    • G. Miniutti
    • , R. D. Saxton
    • , M. Giustini
    • , K. D. Alexander
    • , R. P. Fender
    • , I. Heywood
    • , I. Monageng
    • , M. Coriat
    • , A. K. Tzioumis
    • , A. M. Read
    • , C. Knigge
    • , P. Gandhi
    • , M. L. Pretorius
    •  & B. Agís-González
  • Letter |

    Landmarks of early stages of human embryogenesis can be recapitulated in a highly controllable and scalable fashion by culturing human pluripotent stem cells in a microfluidic device.

    • Yi Zheng
    • , Xufeng Xue
    • , Yue Shao
    • , Sicong Wang
    • , Sajedeh Nasr Esfahani
    • , Zida Li
    • , Jonathon M. Muncie
    • , Johnathon N. Lakins
    • , Valerie M. Weaver
    • , Deborah L. Gumucio
    •  & Jianping Fu
  • Letter |

    Excitation to the second excited state of 229Th is used to populate the metastable state 229mTh, enabling accurate determination of the isomer’s energy, half-life and excitation linewidth.

    • Takahiko Masuda
    • , Akihiro Yoshimi
    • , Akira Fujieda
    • , Hiroyuki Fujimoto
    • , Hiromitsu Haba
    • , Hideaki Hara
    • , Takahiro Hiraki
    • , Hiroyuki Kaino
    • , Yoshitaka Kasamatsu
    • , Shinji Kitao
    • , Kenji Konashi
    • , Yuki Miyamoto
    • , Koichi Okai
    • , Sho Okubo
    • , Noboru Sasao
    • , Makoto Seto
    • , Thorsten Schumm
    • , Yudai Shigekawa
    • , Kenta Suzuki
    • , Simon Stellmer
    • , Kenji Tamasaku
    • , Satoshi Uetake
    • , Makoto Watanabe
    • , Tsukasa Watanabe
    • , Yuki Yasuda
    • , Atsushi Yamaguchi
    • , Yoshitaka Yoda
    • , Takuya Yokokita
    • , Motohiko Yoshimura
    •  & Koji Yoshimura

Latest Reviews & Analysis

  • News & Views |

    Silicon anodes in lithium batteries expand during discharge, causing failure. This expansion has been used constructively in a material whose architecture controllably and reversibly changes to alter its function.

    • Seung-Yeol Jeon
    •  & Sung Hoon Kang
  • News & Views |

    Clocks that are based on the nucleus of a single thorium atom could be more precise than existing timekeepers. Such clocks have not yet been realized, but two experiments provide keys steps towards this goal.

    • Jason T. Burke
  • News & Views |

    An innovative microfluidic device has enabled the modelling of the events that occur in human embryos when they implant in the wall of the uterus. It could be used to help understand early pregnancy loss.

    • Amander T. Clark
  • News & Views |

    How Nature reported computer-made music in 1969, and a book on the early history of numbers in 1919.

  • News & Views |

    T-cell receptors orchestrate immune-system responses against infection and cancer. A structure of an entire T-cell receptor complex clarifies its assembly and signalling, and sheds light on its dynamic ligand recognition.

    • Ellis L. Reinherz

News & Comment

Nature Outlook

Opioids

Daniel Stolle

Opioids

Addiction to opioid drugs is an urgent health-care crisis. Researchers and policymakers are pursuing strategies that range from developing non-opioid pain relief to establishing new norms for prescribing these problematic medications.

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