Latest Research

  • Letter |

    Organoids derived from human stem cells recapitulate the structure and functions of human blood vessels, and can be used to model and identify regulators of diabetic vasculopathy.

    • Reiner A. Wimmer
    • , Alexandra Leopoldi
    • , Martin Aichinger
    • , Nikolaus Wick
    • , Brigitte Hantusch
    • , Maria Novatchkova
    • , Jasmin Taubenschmid
    • , Monika Hämmerle
    • , Christopher Esk
    • , Joshua A. Bagley
    • , Dominik Lindenhofer
    • , Guibin Chen
    • , Manfred Boehm
    • , Chukwuma A. Agu
    • , Fengtang Yang
    • , Beiyuan Fu
    • , Johannes Zuber
    • , Juergen A. Knoblich
    • , Dontscho Kerjaschki
    •  & Josef M. Penninger
  • Letter |

    Cell-labelling experiments are used to demonstrate that the hindgut in the chick embryo is formed by cells moving through the stationary caudal intestinal portal as a result of a contractile force gradient directed by fibroblast growth factor signalling.

    • Nandan L. Nerurkar
    • , ChangHee Lee
    • , L. Mahadevan
    •  & Clifford J. Tabin
  • Article |

    Inspired by the enhanced mechanical strength of microstructured metals, damage-tolerant architected materials are developed in which the internal structure is granular, with different regions having different lattice orientations.

    • Minh-Son Pham
    • , Chen Liu
    • , Iain Todd
    •  & Jedsada Lertthanasarn
  • Letter |

    A magnetic contribution to the spin Hall effect is observed in the non-collinear antiferromagnet Mn3Sn, which is attributed to momentum-dependent spin splitting produced by non-collinear magnetic order.

    • Motoi Kimata
    • , Hua Chen
    • , Kouta Kondou
    • , Satoshi Sugimoto
    • , Prasanta K. Muduli
    • , Muhammad Ikhlas
    • , Yasutomo Omori
    • , Takahiro Tomita
    • , Allan. H. MacDonald
    • , Satoru Nakatsuji
    •  & Yoshichika Otani
  • Article |

    Transcriptomic and genetic analyses of a deletion set of all known introns in genes of the budding yeast Saccharomyces cerevisiae indicate that introns promote resistance to starvation.

    • Julie Parenteau
    • , Laurine Maignon
    • , Mélodie Berthoumieux
    • , Mathieu Catala
    • , Vanessa Gagnon
    •  & Sherif Abou Elela
  • Letter |

    Distinct but partially overlapping subsets of neurons in the orbitofrontal cortex of mice respond to feeding and/or social stimuli and, when optogenetically stimulated at single-cell resolution, specifically regulate reward-seeking behaviours.

    • Joshua H. Jennings
    • , Christina K. Kim
    • , James H. Marshel
    • , Misha Raffiee
    • , Li Ye
    • , Sean Quirin
    • , Sally Pak
    • , Charu Ramakrishnan
    •  & Karl Deisseroth
  • Letter |

    Quantitative explorations using biomechanics and robotics of the gait of Orobates, a stem amniote, indicate that the development of relatively erect, power-saving and balanced locomotion preceded the diversification of crown amniotes

    • John A. Nyakatura
    • , Kamilo Melo
    • , Tomislav Horvat
    • , Kostas Karakasiliotis
    • , Vivian R. Allen
    • , Amir Andikfar
    • , Emanuel Andrada
    • , Patrick Arnold
    • , Jonas Lauströer
    • , John R. Hutchinson
    • , Martin S. Fischer
    •  & Auke J. Ijspeert
  • Letter |

    Increased glutamine metabolism caused by unregulated HIF-1α signalling in mouse chondrocytes results in increased post-translational modification of collagen and skeletal dysplasia, demonstrating that strict regulation of HIF-1α signalling in chondrocytes is essential for normal bone growth.

    • Steve Stegen
    • , Kjell Laperre
    • , Guy Eelen
    • , Gianmarco Rinaldi
    • , Peter Fraisl
    • , Sophie Torrekens
    • , Riet Van Looveren
    • , Shauni Loopmans
    • , Geert Bultynck
    • , Stefan Vinckier
    • , Filip Meersman
    • , Patrick H. Maxwell
    • , Jyoti Rai
    • , MaryAnn Weis
    • , David R. Eyre
    • , Bart Ghesquière
    • , Sarah-Maria Fendt
    • , Peter Carmeliet
    •  & Geert Carmeliet
  • Letter |

    A kiwellin protein in maize is found to inhibit the activity of the secreted enzyme chorismate mutase from a maize-infecting pathogenic fungus, suggesting a role for kiwellins in plant immunity.

    • Xiaowei Han
    • , Florian Altegoer
    • , Wieland Steinchen
    • , Lynn Binnebesel
    • , Jan Schuhmacher
    • , Timo Glatter
    • , Pietro I. Giammarinaro
    • , Armin Djamei
    • , Stefan A. Rensing
    • , Stefanie Reissmann
    • , Regine Kahmann
    •  & Gert Bange

Latest Reviews & Analysis

  • News & Views |

    During the deaths of some massive stars, a narrow beam called a jet is launched through the stellar envelope, leaving an imprint that is difficult to detect. Such an imprint has now been seen in unprecedented detail.

    • Ehud Nakar
  • News & Views |

    Fungal infection can affect crop yield. A plant protein found to counter fungal-induced interference with host metabolism illuminates antifungal defences and mechanisms that inhibit metabolic enzymes.

    • Mary C. Wildermuth
  • News & Views |

    Intron sequences are removed from newly synthesized RNA and usually rapidly degraded. However, it now seems that introns have a surprising role — helping yeast cells survive when nutrients are scarce.

    • Samantha R. Edwards
    •  & Tracy L. Johnson
  • News & Views |

    How Nature reported the death of Theodore Roosevelt in 1919, and a collection of inventions in 1969.

  • News & Views |

    A tenet of elementary biology is that mitochondria — the cell’s powerhouses — and their DNA are inherited exclusively from mothers. A provocative study suggests that fathers also occasionally contribute.

    • Thomas G. McWilliams
    •  & Anu Suomalainen

News & Comment

Nature Outline

Liver cirrhosis

Andrew Khosravani

Liver cirrhosis

Long considered to be permanent, the extensive scarring found in livers with cirrhosis is now thought to be reversible.

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