Latest Research

  • Letter |

    RNA-dependent DEAD-box ATPases (DDXs) regulate the dynamics of phase-separated organelles, with ATP-bound DDXs promoting phase separation, and ATP hydrolysis inducing compartment disassembly and RNA release.

    • Maria Hondele
    • , Ruchika Sachdev
    • , Stephanie Heinrich
    • , Juan Wang
    • , Pascal Vallotton
    • , Beatriz M. A. Fontoura
    •  & Karsten Weis
  • Article |

    The pore-forming and ATP-binding subunits of a mitochondrial protein complex that mediates ATP-dependent potassium currents are identified and characterized, revealing the role of this channel in mitochondrial physiology and pathologies.

    • Angela Paggio
    • , Vanessa Checchetto
    • , Antonio Campo
    • , Roberta Menabò
    • , Giulia Di Marco
    • , Fabio Di Lisa
    • , Ildiko Szabo
    • , Rosario Rizzuto
    •  & Diego De Stefani
  • Letter |

    Shot-noise measurements in copper oxides reveal paired charge carriers existing in the pseudogap above the superconducting critical temperature, shedding light on the properties of high-temperature superconductivity in these materials.

    • Panpan Zhou
    • , Liyang Chen
    • , Yue Liu
    • , Ilya Sochnikov
    • , Anthony T. Bollinger
    • , Myung-Geun Han
    • , Yimei Zhu
    • , Xi He
    • , Ivan Boz̆ović
    •  & Douglas Natelson
  • Article |

    RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.

    • Rebecca D. Hodge
    • , Trygve E. Bakken
    • , Jeremy A. Miller
    • , Kimberly A. Smith
    • , Eliza R. Barkan
    • , Lucas T. Graybuck
    • , Jennie L. Close
    • , Brian Long
    • , Nelson Johansen
    • , Osnat Penn
    • , Zizhen Yao
    • , Jeroen Eggermont
    • , Thomas Höllt
    • , Boaz P. Levi
    • , Soraya I. Shehata
    • , Brian Aevermann
    • , Allison Beller
    • , Darren Bertagnolli
    • , Krissy Brouner
    • , Tamara Casper
    • , Charles Cobbs
    • , Rachel Dalley
    • , Nick Dee
    • , Song-Lin Ding
    • , Richard G. Ellenbogen
    • , Olivia Fong
    • , Emma Garren
    • , Jeff Goldy
    • , Ryder P. Gwinn
    • , Daniel Hirschstein
    • , C. Dirk Keene
    • , Mohamed Keshk
    • , Andrew L. Ko
    • , Kanan Lathia
    • , Ahmed Mahfouz
    • , Zoe Maltzer
    • , Medea McGraw
    • , Thuc Nghi Nguyen
    • , Julie Nyhus
    • , Jeffrey G. Ojemann
    • , Aaron Oldre
    • , Sheana Parry
    • , Shannon Reynolds
    • , Christine Rimorin
    • , Nadiya V. Shapovalova
    • , Saroja Somasundaram
    • , Aaron Szafer
    • , Elliot R. Thomsen
    • , Michael Tieu
    • , Gerald Quon
    • , Richard H. Scheuermann
    • , Rafael Yuste
    • , Susan M. Sunkin
    • , Boudewijn Lelieveldt
    • , David Feng
    • , Lydia Ng
    • , Amy Bernard
    • , Michael Hawrylycz
    • , John W. Phillips
    • , Bosiljka Tasic
    • , Hongkui Zeng
    • , Allan R. Jones
    • , Christof Koch
    •  & Ed S. Lein
  • Article |

    The solute carrier transporter protein SLC25A44 regulates uptake of branched-chain amino acids in mitochondria of brown adipose tissue in which they are utilized for thermogenesis.

    • Takeshi Yoneshiro
    • , Qiang Wang
    • , Kazuki Tajima
    • , Mami Matsushita
    • , Hiroko Maki
    • , Kaori Igarashi
    • , Zhipeng Dai
    • , Phillip J. White
    • , Robert W. McGarrah
    • , Olga R. Ilkayeva
    • , Yann Deleye
    • , Yasuo Oguri
    • , Mito Kuroda
    • , Kenji Ikeda
    • , Huixia Li
    • , Ayano Ueno
    • , Maki Ohishi
    • , Takamasa Ishikawa
    • , Kyeongkyu Kim
    • , Yong Chen
    • , Carlos Henrique Sponton
    • , Rachana N. Pradhan
    • , Homa Majd
    • , Vanille Juliette Greiner
    • , Momoko Yoneshiro
    • , Zachary Brown
    • , Maria Chondronikola
    • , Haruya Takahashi
    • , Tsuyoshi Goto
    • , Teruo Kawada
    • , Labros Sidossis
    • , Francis C. Szoka
    • , Michael T. McManus
    • , Masayuki Saito
    • , Tomoyoshi Soga
    •  & Shingo Kajimura
  • Article |

    Cryo-electron microscopy and high-speed atomic force microscopy reveal that PIEZO1 can reversibly deform its shape towards a planar structure, which may explain how the PIEZO1 channel is gated in response to mechanical stimulation.

    • Yi-Chih Lin
    • , Yusong R. Guo
    • , Atsushi Miyagi
    • , Jesper Levring
    • , Roderick MacKinnon
    •  & Simon Scheuring
  • Letter |

    Soil radiocarbon dating reveals that combusted ‘legacy carbon’—soil carbon that escaped burning during previous fires—could shift the carbon balance of boreal ecosystems, resulting in a positive climate feedback.

    • Xanthe J. Walker
    • , Jennifer L. Baltzer
    • , Steven G. Cumming
    • , Nicola J. Day
    • , Christopher Ebert
    • , Scott Goetz
    • , Jill F. Johnstone
    • , Stefano Potter
    • , Brendan M. Rogers
    • , Edward A. G. Schuur
    • , Merritt R. Turetsky
    •  & Michelle C. Mack
  • Letter |

    The dynamics of interactions between hate-orientated networks on different online platforms is characterized, and a mathematical model predicts that policing on one online platform can make matters worse and generate ‘darker’ parts of the Internet.

    • N. F. Johnson
    • , R. Leahy
    • , N. Johnson Restrepo
    • , N. Velasquez
    • , M. Zheng
    • , P. Manrique
    • , P. Devkota
    •  & S. Wuchty

Latest Reviews & Analysis

  • News & Views |

    Carbon has been stored in the organic layers of boreal-forest soils for hundreds of years. An analysis reveals that this carbon might be released into the atmosphere as global warming increases the frequency of wildfires.

    • Cornelia Rumpel
  • News & Views |

    The movement of small droplets on a substrate is governed by surface-tension forces. A technique that can tune the surface tension of robust oxide substrates for droplet manipulation could open up many applications.

    • Frieder Mugele
  • News & Views |

    An analysis of the dynamics of online hate groups on social-media platforms reveals why current methods to ban hate content are ineffective, and provides the basis for four potential strategies to combat online hate.

    • Noemi Derzsy
  • News & Views |

    Piezo proteins mediate the sense of touch. A near-complete structure of one such protein has been obtained, and the mechanism for converting mechanical signals into electrical ones has been probed in another.

    • Edwin W. McCleskey
  • News & Views |

    Whether cell types in the brain have been conserved during evolution is not clear. A comparison of the molecular recipes that define brain cell types in humans and mice reveals similarities and differences between species.

    • Matthew G. Keefe
    •  & Tomasz J. Nowakowski
  • News & Views |

    Immune cells called monocytes enter the lung during infection. Whether they help to launch a defence response is affected by the pressure encountered there, which is sensed by an ion channel called PIEZO1.

    • Sarah R. Walmsley

News & Comment

Nature Outlook

The brain

Sam Falconer

The brain

The human brain isn’t much to look at. In the hand, it is a jelly-like mass, easily deformed by touch. But its unassuming appearance belies complex inner workings, many of which are still a mystery to scientists.

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