Here, the authors identify 200 Varicella-Zoster Virus (VZV) circRNAs, confirmed in HZ patient tissues. Numerous latency-associated transcripts (VLTs)-like circRNAs (circVLTslytic) were found with multiple exons and splice donor sequences that influence formation. circVLTslytic RNAs are non-essential for VZV replication but affect ACV sensitivity.
- Shaomin Yang
- Di Cao
- Hua Zhu